Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

LSM3211 > Transmembrane Receptor Enzymes > Flashcards

Transmembrane Receptor Enzymes Flashcards

1
Q

what aer the three types of transmembrane receptor enzymes

A

receptor tyrosine kinase
receptor serine/threonine kinase
receptor guanylyl cyclase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what are the types of receptor tyrosine kinases

A

insulin receptor
human epidermal growth factor receptor(HER)
platelet derived growth factor receptor(PDGF)
vascular endotheilai growth factor receptor (VEGF)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what are the different types of receptor serine/threonin kinase

A

transforming growth factor B (TGF-B) receptor
activin and inhibin receptor
bone morphogenic protein(BMP) receptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what are the type of reecptor guanylyl cyclase

A

atrial natriuretic peptide(ANP) receptor
GC-A
GCB
GCC receptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what is the mechanism of receptor tyrosine kinase?

A

from inactive monomers, they become inactive dimers and cross phsophorylate and casue the active dimer
they can also become acitve dimers straight away, adn once they ligand bind, they result in the ligand bound active dimer, that result in the sigalling

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

which domain allow for auto phosphorylation of the tyrosine kinase receptors

A

Src homology 2 domain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

how many ways can phosphorylation occure

A

auto phosphorylation and substrate phsophrylation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what are the pathways that lead to cellular proliferation response ? from which receptor does it occure

A

EGFR Tyrosine kinase activation
- Mitogen activated protein Kinase Pathway
- Phospholipase Cy pathway
- Phosphatidylinositol 3 kinase athway

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Describe the Receptor Tyrosine Kinsae: PLCy pathway

A

When the PLCY is activaed by phosphorylation,
it converts PIP2 into DG and IP3

dag which is converted into PKC

IP3 causes CA2+ to increase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

describe the receptor tyrosoine kinase:PI3K pathway

A

PI3 kInsae result in convertions of PIP2 into PIP3

PIP3 result in attraction of peckstrin homology with the phosphatidylinositol depdendeent kindase 1

Activation of Akt (Protein Kinase B )

promote cell survival and inhibit apoptosis by phosphorylating and inactivating pro-apoptotic proteins such as Bad and caspase-9.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

describe the MAPK signaling pathway

A

GDP to GTP at Ras

result on Raf creation
Mak
Map kinase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

list the epidermal growth factor receptor inhibitor that causes inhibition of cancer

A

HER1 inhibitors

drug name : Geftinib, erlotinib
biologics: cetuximab, panitumumab

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

list the epidermal growth factor receptor inhibitor that causes inhibition of breast cancer

A

HER2

small molecules: Lapatinib
biologics: Trastuzumab

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Platelt derived Growth Factor Receptor Inhibitor

A

Imatinib for cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Vacsular Endothelial Growth Factor(VEGF) Receptor Inhibitor for Cancer

A

Sunitinib, Sorafenib
biologica: Bevacizumab

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Vacsular Endothelial Growth Factor(VEGF) Receptor Inhibitor for Muscle Degeneration

A

Oligonucleotide drug: Pegaptanib binds and blocks VEGF actions via intravitreal injections

17
Q

what are some functions the Receptor Serin/Threonine kindase : Transforming Growth Factor B Receptor are related to?

A

Growth Arrest
Cancer
Promote Apoptosis
Fibrosis
Angiogenesis
Immunomodulation
Atherosclerosis
Inflammation

  • this thus makes it diffficult to design an inhibitor without causing any side effects
18
Q

receptors of Receptor Serine/ Theronin Kinase(TGFB) when the ligand binds

A

They will already be in a dimer and once the receptor binds, they become heterotetramer(dimer bind with dimer)
cross phosphorylation would happen adn then the MH2 AND MH1 Rsmad would be attracted

19
Q

what is SMAD

A

It has a mad homology1 and mad homology 2
- mad holomolgy 1 bind ot DNA while mad homology 2 bings for receptor kinase interactions and causes trasncriptional activation

20
Q

For bone morphology protein what are the R smads

A

1,5,8

21
Q

for TGF-B what are the R smad

A

2,3

22
Q

what are cosmads

A

they are smad4 that combine with Rsmad to move into the nucleus and regulate gene expression

23
Q

inhibitory smad

A

6, 7
interact with Rsmad and ensure they cannot bind tot eh DNA, thus no gene trasncription process

24
Q

Drug development for TGF B receptor signaling- Anti-TFG-B mAb

A

Fresolimumab

25
Q

Drug development for TGF B receptor signaling- TBRI Kinase inhibitor

A

Vactosertib

26
Q

Drug development for TGF B receptor signaling- Recombinant Human Bone Morphogenic Protein

A

rhBMP-2- for spinal deformity
rhBMP-7- for bone nonuniors

27
Q

Drug development for TGF B receptor signaling- Activin Receptor Ligand Traps

A

Activin Receptor Type IIB-Fc Fusion Protein
Luspatercept- Anemia in B thalassemia

28
Q

Drug development for TGF B receptor signaling- Activit Receptoy type IIA-Fc Fusion protien

A

Sotatercept- Pulmanory Arterial hypertension(PAH)

29
Q

What happens when TGF-B binds to the TBRII and TBRI recpetors

A

smad2or 3 will be released after the cross phosphorylation of the heterotetramer
the smad2/3 binds with the COSMAD to modulate the geen expression

30
Q

Receptor Guanylyl Cyclase(GC) what are they and their ligands

A

there are NPR-A (GCA)- Atrial NP(ANP) and Brain NP(BNP)
NPR-B CNP from endothelial and renal cells
NPR-C clearance receptor for anp, bnp, cnp

GCC- Uroguanylin and Guanylin
GCA, GCB, GCC- are mainly in the CVS, skeletal system adn GI tract
GCD AND GCG- absent in the human
GCE AND GCF- in the retinal photoreceptors

31
Q

how many domains do the Natruretic peptide receptor have

A

ligand binding domin
kinse homology domain
hinge region
Guanylyl cyclase domain

32
Q

drugs for the Natriuretic Peptide Receptors

A

ANP: Carperitide, for short term acute decompensated CHF
BNP: Mesiritide: for short terms acute decompensated CHF
CNP: cenderititde for natiuresis, diuresis and cardiac fibrosis

33
Q

function of PCGA

A

Natrurietic
aterial vasodialtion
renin and aldosterone suppressing
anti apoptotic
anti hypertrohic
lusitropic
lipolytic

34
Q

function of PGCB

A

anti fibrotic
anti inflammatory
vascular regenerating

35
Q

GCC receptor agonist

A

linaclotid and plecanatide
for chronic idiopathic constipation and IBD predominant constipation
and GI tumorigenesis

LSM3211 (14 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions