transport of oxygen and co2

Question 1

CO2 production by cells

Answer 1

200ml/min

Question 2

metabolic arteriovenous CO2 difference

Answer 2

40ml/L

Question 3

metabolic arteriovenous O2 difference

Answer 3

50ml/L

Question 4

O2 use by cells

Answer 4

250ml/mi

Question 5

tissue pCO2

Answer 5

> 50

Question 6

tissue PO2

Answer 6

> 10

Question 7

hypoxic hypoxia

Answer 7

inadequate O2 uptake in lungs

Question 8

stagnant (ischemic) hypoxia

Answer 8

inadequate blood flow to an organ (arteriosclerosis, PVD, stroke, MI)

Question 9

anemic hypoxia

Answer 9

inadequate blood o2 carrying capacity. inactivated hemoglobin

Question 10

histotoxic hypoxia

Answer 10

interference with mitochondrial respiration (like cyanide poisoning)

Question 11

normal Hb

Answer 11

15g/dL

Question 12

RBC carry ___ times more o2 than plasma

Answer 12

65

Question 13

how many subunits does hb have

Answer 13

4

Question 14

each gm of Hb can carry up to how much o2?

Answer 14

1.31ml

Question 15

what shape is the Hbo2 curve

Answer 15

sigmoid

Question 16

the ratio of o2 bound to hb compared to total amount that can be bound is

Answer 16

oxygen saturation

Question 17

maximal amt of o2 bound to hb is

Answer 17

oxygen capacity

Question 18

***what is the Hb P50 point

Answer 18

27!!!

Question 19

what is your paO2 when the sat is 90

Answer 19

60

Question 20

what is your paO2 when the sat is 50

Answer 20

27!

Question 21

rough rule for sat to Pao2

Answer 21

40,50,60 for sat 70,80,90

Question 22

the higher the affinity, the ___ the saturation

Answer 22

higher

Question 23

the top of the curve represents

Answer 23

lungs

Question 24

the middle of the curve represents

Answer 24

capillaries

Question 25

the starting point of the curve represents

Answer 25

tissues

Question 26

the x axis on curve

Answer 26

po2

Question 27

the y axis

Answer 27

hb sat %

Question 28

carbon monoxide has ___ times the affinity for Hb than O2

Answer 28

250

Question 29

nitric oxide binds to Hb _____ times more strongly than o2

Answer 29

200000.

Question 30

what is NO used for

Answer 30

to treat pulmonary hypertension

Question 31

as PaO2 in the tissues decreases, the __ affinity Hb has for it, so...

Answer 31

less, so O2 is dumped in the tissues

Question 32

left =

Answer 32

love = lungs

Question 33

right =

Answer 33

release

Question 34

which way does alkalosis shift the curve

Answer 34

left

Question 35

which way does acidosis shift the curve

Answer 35

right

Question 36

which way does hyperthermia shift the curve

Answer 36

right

Question 37

which way does hypothermia shift the curve

Answer 37

left

Question 38

which way does increased 2,3, DIPG shift the curve

Answer 38

right

Question 39

which way does carboxyhemoglobin and methemoglobin shift the curve?

Answer 39

left

Question 40

which way does increased H+ shift the curve

Answer 40

right

Question 41

which way does increased pCO2 shift the curve

Answer 41

right

Question 42

Bohr effect

Answer 42

Hb releases more o2 in an acidic environment. an increase in H+ decreases the Hb's affinityy for o2. its the cells way of asking hb to release o2 to support aerobic metabolism

Question 43

PRBC's in the package shift the curve

Answer 43

left... because cold and less 2,3. dipg

Question 44

myoglobin has ___ affinity for O2, and this causes a shift to the ____

Answer 44

increased, left

Question 45

fetal blood causes a shift

Answer 45

left

Question 46

O2 content in blood is the sum of

Answer 46

carried on Hb and dissolved

Question 47

shift up is caused by

Answer 47

increased 02 capacity-

Question 48

shift down is caused by

Answer 48

decreased 02 capacity - anemia

Question 49

CO production in a resting adult

Answer 49

200ml/min. increases 6 fold with exercise.

Question 50

what are the 3 ways CO2 is transported by blood

Answer 50

as a gas dissolved directly in food, bicarb, ad bound to hb and plasma

Question 51

what is the MAIN way co2 is transported

Answer 51

HCO3 bicarb! 70%

Question 52

venous blood transports ___ CO2 than arterial blood

Answer 52

more

Question 53

haldane effect

Answer 53

upon binding o2, HB releases CO2 and H+ which in turn is converted to CO2. increased O2 causes the erythrocyte to release CO2. deoxygenated blood (venous) is able to carry more CO2

Question 54

shifting the curve ___ causes decreased o2 delivery to tissues

Answer 54

left

Question 55

the reaction that converts CO2 to HCO3 requires

Answer 55

the enzyme carbonic anhydrase

Question 56

mixed venous blood in pulm artery sat and pa02

Answer 56

75% paO2 40

Question 57

what binds irreversibly to hb

Answer 57

nitric oxide

Question 58

venous hb affinity shift

Answer 58

Po2 of 70 mmHg Shift to the right reducing the affinity for O2 below. shifting occurs bc of Bohr effect - an increase in H+ decreases hb's affinity for o2. increases delivery of o2 to tissues

Question 59

Cao2 formula

Answer 59

(SO2 x hb x 1.31) + (Po2 x 0.003)

Question 60

DO2 (oxygen delivery)

Answer 60

caO2 x CO

Question 61

ability to bind with CO2 is ___ in deoxygenated hb

Answer 61

increased

Question 62

the presence of HB in normal arterial blood increase its oxygen concentration approx how many times?

Answer 62

70

Question 63

an increase in what increase 02 affinity of hb

Answer 63

carbon monoxide

Question 64

severe anemia with normal lugs, you'd expect

Answer 64

low oxygen concentration of mixed venous blood

Question 65

in carbon monoxide poisionig you'd expect

Answer 65

reduced oxygen concentration of mixed venous blood