Treatment of Neurodegenrative diseases

Question 1

بسم الله الرحمن الرحيم
__________________
Dementia means ?

Answer 1

Cognitive impairment including memory IN fully cosciouness person

Question 2

Casues of dementia

Answer 2

Primary Alzhemir
Seondary:
Vacular = storke + infarction
Toxins
Tumor
infections
parkinson

Question 3

pathopysiology of alzhemir

Answer 3

Extracullular accumulation of B-amyloid plaques
Intracellular accumulation of Tau protein
causing neuronal degenration especially the cholinergics

Question 4

2 current therapies of Al-zhemir

Answer 4

Cholinimimetics
NMDA Receptor antagonist

Question 5

Cholinestrase inhibitors ex

Answer 5

Donepazil oral
Rivastigmine oral and Transdermal patch

Question 6

The only medication approved for Parkinson dementia ?

Answer 6

Rivastigmine

Question 7

Mention adverse effects of Cholinesterase inhibitors

Answer 7

GIT : NVDA
Bradycardia
Muscle cramps
tremors
Drugn interactions involving CYP450 Except rivastigmine

Question 8

Adventages of Rivastigmine ?

Answer 8

No drug interaction
Transdemal patch
used in Alzhemir dmentia the only drug !

Question 9

Mematnie mechnaims describe

Answer 9

its is NMDA Receptor antagnist Preventing ca entering in huge amount preventing Apoptosis of neurons

Question 10

Adverses of Memantine

Answer 10

Confusion Dizness headache constipation
Constipation

Question 11

Depression and psychosis of alzemir treat ?>

Answer 11

Depression SSRI AND TCA
PSYCHOSIS AOR
Ariprazole
Olanzopine
Respridone

Question 12

Autoimmnue inflammatory demyelinating disease of CNS

Answer 12

Multipe sclerosis
Chronic relapsing progressive disease

Question 13

Mangemetn oF MS

Answer 13

Treatment of Acute episode
Disease modifying drugs
symptomatic treatment

Question 14

Methylprednisolone dose and form in MS

Answer 14

For acute exacerbations release
1g/d IV for 5 days followd by tepered oral predinsone

Question 15

Corticosteroids catabolic side effects

Answer 15

Catabolic :
Carbohydrate : hyperglycemia
Fat:lipolysis and fat distribuation
Protein = muscle wasting + Retardation of growth + osteoprosis
may cause pshcosis and depression

Question 16

Corticosteriods cause edema and HTN why?

Answer 16

Due to salt and water retention

Question 17

Mention 3 side effects of Coricosteorids

Answer 17

Peptic ulcer
increase infections
Decreased wound healing + Hirsutism

Question 18

Disease modyfing drugs in MS

Answer 18

-INTF NATALI CHEMO
-1-Interferon B SC IM
-2-Figolimod Oral
-3-Natalizumab IV infusion
-4-Chemotheraputic agents as
cyclophospamide and azathioprine

Question 19

Fisrt line in modifying MS and its adverse effects

Answer 19

Interferon beta
Flu like symptoms
Depression
Reaction at site of injetion
AST and ALT ELEVATION

Question 20

First ORAL DMDS is ?

Answer 20

Fingilomod

Question 21

Lymphocyte sequestation done by?

Answer 21

Fingilimod
S1P1 attachement

Question 22

First dose bradycardia in DMDs by?>

Answer 22

Finglimoid

Question 23

Macular edema increased in DM in DMDs by?

Answer 23

Fingiliomd

Question 24

Finglimod adverses ?

Answer 24

Fist dose bradycardia
Increased Risk of infection
macualr edema

Question 25

Monoclonal antibody attaching to alpa 1 beta 4 integrin for no attahcment OF t cells to VCAM1 for no passing thorigh BBB TO CENTRAL NEURONS

Answer 25

NATALI NATALIZIUMAB

Question 26

K channel blocker improving walking FDA has given it approval as a symptomatic treatment in MS ?

Answer 26

Dal Fampridine

Question 27

Fatigue = ? muscle spasticiy= ? Tremors Neuralgia

Answer 27

modafinil diazepam inderal carabamazpine antitiptyline

Question 28

Amyotrophic lateal scelrosis ALS

Answer 28

by genetic and ENVIRONMENTAL : Metals pesticides EMF

Question 29

dEGENRATION Of lateral coritcospinal upper motor also lower motor ccures in ?

Answer 29

ALS

Question 30

Theroetical pathophysiology of ALS ?

Answer 30

iNCREASED glutamate on NAMDA increasing intracellular calcium causing apoptisis

Question 31

Delaying need for ventilarot for 3months IN ALS ?

Answer 31

Rilozoule

Question 32

Delaying need for ventilarot for 3months IN ALS ?

Answer 32

Riluzole

Question 33

Rilzuole action ?

Answer 33

Blocking Na Channels preventing glutamate relase to NMDA ? Preventing Ca entery

Question 34

Rilzuole action ?

Answer 34

Blocking Na Channels preventing glutamate relase to NMDA ? Preventing Ca entery so it is NMDA indirect antagonist right ?!

Question 35

الحمدلله رب العالمين