Tricyclic Antidepressants Flashcards
1
Q
What are TCAs (tricyclic antidepressants) used for?
A
Depression (limited use now) Neuropathic pain (wide use, smaller doses)
2
Q
Why are TCAs not used so much in depression now?
A
Side-effects and toxicity in overdose
3
Q
6 common side-effects of TCAs? (similar to antipsychotics)
A
Blurred vision Dry mouth Urinary retention Constipation Drowsiness Lengthening of QT interval
4
Q
Which TCA has a lower incidence of toxicity in overdose?
A
Lofepramine
5
Q
Which TCAs are most dangerous in overdose?
A
Amitriptyline
Dosulepin
6
Q
Which 3 TCAs are more sedative and which 3 TCAs are less sedative?
A
More Sedative (remember a couple of these are more toxic in overdose)
Amitriptyline
Clomipramine
Dosulepin
Less Sedative
Imipramine
Lofepramine
Nortriptyline
