Triple whammy effect

Question 1

What do NSAIDs effect on kidney

Answer 1

• Vasoconstrict the afferent arteriole to the glomerulus

- Decrease filtration rate and amount of blood in he efferent arteriole

Question 2

What is the consequence of kidney from taking NSAID’s Long term?

Answer 2

• decrease in glomerulus filtration rate

- May lead to ischemia of parts of the kidney

Question 3

What is the effect of ACEi and ARB on the kidney?

Answer 3

• vasodilate the efferent arteriole
• Protective in diabetes arteriosclerosis
• harmful if stenosis of renal artery, late chronic kidney disease

Question 4

What effect does the Diuretic have on the kidney?

Answer 4

-increases plasma clearance and reduce plasma volume

Question 5

What is the triple whammy effect?

Answer 5

• acute kidney injury when, NSAIDs, Diuretic and ACEi/ARB is taken together
• Fatal in high risk patients particularly in older population