Tumor Flashcards by T. J. Porter

S100+

Chondroblastoma
Eosinophilic granuloma
Schwannoma
MPNST
Melanoma
\+/- Neurofibromas
Synovial sarcoma
Clear cell sarcoma

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Metaphyseal

Chondromyxoid fibroma

Chondrosarcoma

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Most common primary malignant spine tumor

Chordoma

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Keratin positive

Adamantinoma
Chordoma
Epitheloid sarcoma
Synovial sarcoma
CARCINOMAS

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Ubiquitin specific protease USP6

ABC

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Multiple enchondromas diseases

Ollier’s

Maffucci’s (+ angiomas, malignant transformation)

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Vertebra plana (MELT)

Mets/Myeloma
EG + Ewing’s
Lymphoma + leukemia
Trauma + TB

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Hand-Schuller-Christian disease

EG with skull and visceral lesions, diabetes insipidus, exophthalmos
Kids >3
Give CHEMO

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Letterer-Siwe disease

Form of EG

FATAL (age <3)

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CD99

Ewing’s

Other neuroendocrine tumors (PNET)

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Staging for Ewing’s

Bone scan
BM biopsy
CT chest

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Fibrodysplasia ossificans progressiva

Form of myositis ossificans
ACVR1 gene mutation
BMP4

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Melorheostosis

Formation of new periosteal bone
More common in LE
Symptomatic tx

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Multiple NOF disorder

Jaffe-Campanacci syndrome (+ MR, cafe au lait spots)

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What can mimic NOF

Adductor magnus insertion avulsion

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Fibrous dysplasia mutation

GS alpha protein ACTIVATING mutation

Increases cAMP

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McCune-Albright syndrome

Poly-ostotic fibrous dysplasia
Coast of Maine spots (jagged edges)
Precocious puberty

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Mazabraud syndrome

Poly-ostotic fibrous dysplasia + muscular myxomas

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Medical treatments for GCT

Bisphosphonates

Denosumab

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t(12;16) translocation

Myxoid liposarcoma (TLS-CHOP)
Signet ring cells

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MDM2/CDK4 biomarkers

Liposarcoma

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Most common site of bone mets

T spine

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When to get skeletal survey for stagings

Myeloma

Thyroid CA

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Myeloma biomarker

CD38

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Rhabdomyosarcoma staging

BM biopsy | CT chest

t(2:13) or (1:13) translocation

Rhabdomyosarcoma

Rhabdomyosarcoma fusion protein

Pax3 or Pax7-FKHR

Rhabdomyosarcoma biomarker

Desmin

Origin of osteochondromas

Perichondrial ring

Normal cartilage cap in osteochondromas

<2 cm

Mutation in MHE

Prehypertrophic chondrocyte layer

When osteochondromas grow TOWARDS joints

Metachondromatosis (enchondromas + osteochondromas)

Osteiod osteoma products that cause pain

Prostaglandin E2 | Cox 1/2

Type of osteosarcoma NOT responsive to chemo

Parosteal

Gene assoc w/ Schwannoma

NF2

Gene assoc w/ MPNST

NF1

Neoplastic cell in PVNS

Phagocyte

Lymph node mets mnemonic (ESARC)

``` Epitheloid Synovial sarcoma Angiosarcoma Rhabdomyosarcoma Clear cell sarcoma ```

Diaphyseal tumors (AEIOU Y)

``` Adamantinoma Eosinophilic granuloma Infection Osteoid osteoma, osteoblastoma Ewing's Y = Myeloma, lymphoma, fibrous dysplasia ```

t(12:22) translocation

Clear cell sarcoma

MIC-2 biomarker

Ewing's

HMB45 biomarker

Melanoma | Clear cell sarcoma

t(12:16) translocation

Myxoid liposarcoma

t(2:13) or (1:13) translocation

Rhabdomyosarcoma (alveolar)

Small round blue cell tumors (LERNM)

``` Lymphoma Ewing's Rhabdomyosarcoma Neuroblastoma Myeloma ```

Li Fraumeni syndrome (SBLA)

Sarcoma Breast Leukemia Adrenal gland

POEMS syndrome assoc w/ myeloma

``` Polyneuropathy (PN damage) Organomegaly Endocrinopathy M-protein (immunoglobulin) Skin abnormalities (hyperpigmentation) ```

Get a BM biopsy

Ewing's | Myeloma

Get a bone scan

Osteosarcoma Ewing's Mets

Rb chromosomal abnormality

Chr 13

CD34, CD31

Hemangioma Hemangioendothelioma Angiosarcoma

Beta catenin

Fibromatosis

Epithelial membrane antigen

Epithelioid sarcoma | Synovial sarcoma

Rimming osteoblasts

Osteofibrous dysplasia | Osteoblastoma

Worst prognosis when bone mets are present

Lung CA | Melanoma

t(9:22) translocation

Extraskeletal myxoid chondrosarcoma

Colony stimulating factor 1 (CSF1)

PVNS

Pathology in tumoral calcinosis

Phosphate metabolism

MHE gene product functions on:

FGF | Indian hedgehog

Another name for Schwannoma

Neurilemoma | Peripheral nerve sheath tumor

Radiation resistant tumors

Renal | Thyroid

Worst prognostic factor for osteosarcoma

Bone mets

Most common cause of myositis ossificans

Contusion

Nerve roots preserved for near normal bowel/bladder fxn after sacral chordoma resection

Bilateral S2 OR | Unilateral S2-4

Inferior scapular mass

Elastofibroma

Most common small round blue cell tumor in kid <5

Metastatic neuroblastoma

Most common site of mets from soft tissue sarcoma

Lungs

Most common hand malignancy

SCC

Synovial sarcoma translocation

t(X:18)

Synovial sarcoma fusion protein

SYT-SSX

Type of osteosarcoma NOT treated with chemo

PAROSTEAL

DDx small round blue cells in kids

``` Rhabdomyosarcoma NHL Ewing's Wilm's Neuroblastoma ```

Rads RESISTANT mets

Renal | GI

Vertebral body vertical striations on XR

Hemangioma

Assoc w/ arsenic exposure

Hemangiosarcoma

Tumor Flashcards

(75 cards)