Tumor markers/genes/viruses/etc 0422

Question 1

abl

Answer 1

oncogene: CML; tyrosine kinase

Question 2

c-myc

Answer 2

oncogene: burkitt lymphoma; TF

Question 3

bcl-2

Answer 3

oncogene: follicular and undifferentiated lymphomas; anti-apoptotic molecule

Question 4

erb-B2

Answer 4

oncogene: breast, ovarian, gastric carcinomas; tyrosine kinase

Question 5

ras

Answer 5

oncogene: colon carcinoma; GTPase

Question 6

L-myc

Answer 6

oncogene: lung tumor; TF

Question 7

N-myc

Answer 7

oncogene: neuroblastoma; TF

Question 8

ret

Answer 8

oncogene: MEN IIA and IIB; tyrosine kinase

Question 9

c-kit

Answer 9

oncogene: gastrointestinal stromal tumor (GIST); cytokine receptor

Question 10

Rb

Answer 10

tumor suppressor: retinoblastoma, osteosarcoma

Question 11

p53

Answer 11

tumor suppressor: most human cancers, Li-Fraumeni syndrome

Question 12

BRCA1

Answer 12

tumor suppressor: breast and ovarian cancer

Question 13

BRCA2

Answer 13

tumor suppressor: breast cancer

Question 14

p16

Answer 14

tumor suppressor: melanoma

Question 15

APC

Answer 15

tumor suppressor: colorectal carcinoma

Question 16

WT1

Answer 16

tumor suppressor: Wilm’s tumor

Question 17

NF1

Answer 17

tumor suppressor: neurofibromatosis type 1

Question 18

NF2

Answer 18

tumor suppressor: neurofibromatosis type 2

Question 19

DPC

Answer 19

tumor suppressor: pancreatic cancer

Question 20

DCC

Answer 20

tumor suppressor: colon cancer

Question 21

PSA

Answer 21

tumor marker: prostate carcinoma screening. also high in BPH and prostatitis.

Question 22

prostatic acid phosphatase

Answer 22

tumor marker: prostate carcinoma

Question 23

CEA (carcinoembryonic antigen)

Answer 23

tumor marker: CRC, panc, gastric, breast, thyroid medullary

Question 24

alpha-fetoprotein

Answer 24

tumor marker: HCC, non-seminoma germ cell tumor of testis and ovary

Question 25

beta-hCG

Answer 25

tumor marker: Hydatidiform moles, Choriocarcinoma, Gestational trophoblast tumor

Question 26

CA-125

Answer 26

tumor marker: ovarian, malignant epith tumor

Question 27

S-100

Answer 27

tumor marker: melanoma, neural tumor, schwannoma

Question 28

alkaline phosphatase

Answer 28

tumor marker: mets to bone, obstructive biliary disease, Paget disease of bone

Question 29

bombesin

Answer 29

tumor marker: neuroblastoma, lung cancer, gastric cancer

Question 30

TRAP (tartrate-resistant acid phosphatase)

Answer 30

tumor marker: hairy cell leukemia (B cells)

Question 31

CA-19-9

Answer 31

tumor marker: pancreatic adenocarcinoma

Question 32

calcitonin

Answer 32

thyroid medullary carcinoma

Question 33

HTLV-1

Answer 33

microbe: adult T cell leukemia/lymphoma

Question 34

HBV, HCV

Answer 34

microbe: hepatocellular carcinoma

Question 35

EBV

Answer 35

microbe: burkitt lymphoma, hodgkin lymphoma, nasopharyngeal carcinoma

Question 36

HPV

Answer 36

microbe: cervical carcinoma (type 16, 18), penile/anal carcinoma

Question 37

HHV-8

Answer 37

microbe: Kaposi sarcoma, body cavity fluid B cell lymphoma

Question 38

HIV

Answer 38

microbe: primary CNS lymphoma

Question 39

H.pylori

Answer 39

microbe: gastric adenocarcinoma and lymphoma

Question 40

Schistosoma haematobium

Answer 40

microbe: SCC of transitional epith (bladder)

Question 41

aflatoxin (derived from aspergillus)

Answer 41

toxin: HCC

Question 42

vinyl chloride

Answer 42

toxin: angiosarcoma - liver

Question 43

CCL4

Answer 43

toxin: centrilobular necrosis and fatty change - liver

Question 44

nitrosamines (smoked foods)

Answer 44

toxin: gastric cancer

Question 45

cigarette smoke

Answer 45

``` toxin: SCC larynx SCC and small cell LUNG renal cell carcinoma transitional cell carcinoma ```

Question 46

asbestos

Answer 46

toxin: mesothelioma and bronchogenic carcinoma

Question 47

arsenic

Answer 47

toxin: SCC skin; angiosarcoma liver

Question 48

naphthalene (aniline) dyes

Answer 48

toxin: transitional cell carcinoma of bladder

Question 49

alkylating agents

Answer 49

toxin: leukemia

Question 50

ionizing radiation: nuclear reactor accidents, radiotherapy

Answer 50

AML, CML, papillary carcinoma of thyroid

Question 51

non-ionizing radiation: UVB sunlight

Answer 51

all skin cancers - SCC, basal cell, melanoma