Type 1 hypersensitivity Flashcards Preview

Respiratory Osmosis videos > Type 1 hypersensitivity > Flashcards

Flashcards in Type 1 hypersensitivity Deck (13):
1

What is type 1 mediated by

IgE mediated

2

Examples of type 1 hypersensitivity reactions

Allergies, hives, eczema, allergic rhinitis and asthma

3

What is an allergen

Antigen that causes allergic reaction

4

Where do antigen presenting cells present allergens and what do they present it to

Lymph nodes and naive helper t cells

5

Examples of antigen presenting cells

Macrophages and dendritic cells

6

What, along with the allergen, do antigen presenting cells present

Co-stimulatory molecule

7

What do naive helper t cells become once they bind to the allergen and co-stimulatory molecule

Primed helper T cells

8

In response to which interleukens does primed helper t cell become Th2 cells

IL 4,5 and 10

9

What interluekin do Th2 cells release and what effect does it have on B cells

IL-4 and causes B cells to stop producing IgM and produce IgE

10

What interleukin do Th2 cells release that have an effect on eosinophils and what is the effect

IL-5 and stimulates the production and activation of eosinophils. Eosinophils the release toxic substance to destroy allergens

11

What receptors on mast cells do IgE bind to

Fce receptors

12

What cell produces pro-inflammatory mediators during the early sensitization stage

Mast cells

13

Treatment for type 1 hypersensitivity reactions

Antihistamines, corticosteroids and epinephrine.