Type 3 Hypersensitivity Flashcards Preview

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Flashcards in Type 3 Hypersensitivity Deck (13)
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1
Q

What is type 3 hypersensitivity?

A

Immune complex mediated

2
Q

What is involved?

A

Immune complexes between IgG and IgM

3
Q

What are the targets?

A

Soluble antigens

4
Q

How is tissue damage caused?

A

Deposition of immune complexes in tissues

5
Q

What factors affect immune complex pathogenesis?

A

Complex size
Host response
Local tissue factors

6
Q

What happens to small immune complexes?

A

Cleared by RES system

7
Q

What happens to intermediate size immune complexes?

A

Host unable to clear

8
Q

What happens to large immune complexes?

A

Cleared by complement system

9
Q

What are some disease caused by type 3 hypersensitivity?

A

Rheumatoid arthritis
Glomerulonephritis
SLE

10
Q

What is the antigen in RA?

A

Fc portion of IgG

11
Q

What is the antigen in SLE?

A

Ds-DNA

12
Q

What are the symptoms of SLE?

A

Low grade fever
Malar rash
Photosensitivity

13
Q

How can type 3 hypersensitivity be managed?

A

Anti-inflammatory drugs

Monoclonal antibodies