Types of stem cell transplant Flashcards Preview

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Flashcards in Types of stem cell transplant Deck (13):
1

Autollogous

Uses patients own blood cells

2

Allogenic

any transplant in which stem cells come from a donor

3

Types of donor

Syngenic - identical twins
Allogenic sibling - HLA
Haplotypes identical - half matched family member
Volunteer- unrelated donor (VUD)
Umbillical cord

4

Autologous

patients receive G-CSF +/- chemotherapy to make SC leave BM so they can be collected from blood

5

Main indication of autologus transplant

Lymphoma

6

Allogenic

Uses peripheral blood SC, BM or umbillical cord from host to patient

may be full "myeloablative or reduced intensity "mini" transplant

7

Main indication of allogenic

acute and chronic leukaemia

8

GVs host disease

Patients immune system recognises hosts body as foregin

Acute vs host
- within the first 100 days

chronic vs host
-after first 100 days

9

Graft vs leukaemic

some cells that cause GVHD attack the remaining leukaemic cells

10

Volunteer unrelated donor

match not blood related

11

Myeloalblative regimen

line (hickman) put in (through front of chest and feeds into heart vessles)

Conditioning therapy - total body irration and chemo at a high dose

BMT- convert to donors immune system

12

Blood cord transplant

Blood stem cells are collected from umbilical cord and placenta
Not the baby!
Cells are tissue typed and frozen in liquid nitrogen in cord blood banks for future use

Advantages:
More rapidly available than VUD
Less rigorous matching to patient type of patient as immune system naive

Disadvantages:
Small amount – adults will often require double cord transplant
Slower engraftment
If relapse, cannot go back for DLI

13

Mini-transplant

Condition
-low dose chemo

BMT (mixed patient chimera of donor and host cells)

Donor lymphocytes - convert fully to donor cells