Ultrasound Flashcards

(503 cards)

1
Q

Describe how a sound wave is formed

A

A piston moves and the air is momentarily squashed into areas of high and low pressure.
The direction of particle displacement is along the direction of propagation

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2
Q

What are areas of high pressure in wave formation called?

A

Compression

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3
Q

What are areas of low pressure in wave formation called?

A

Rarefaction

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4
Q

What is frequency?

A

f
The number of complete cycles per s
Hz

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5
Q

What is wavelength?

A

The distance travelled over 1 cycle

It is the distance between adjacent areas of high pressure

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6
Q

What is a period?

A

T

The time for one complete cycle

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7
Q

What is the relationship between time and frequency?

A

T = 1 / f

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8
Q

What is the fundamental equation that applies to any wave?

A

C = f x wavelength

Speed of sound = frequency x wavelength

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9
Q

What is the average speed of sound in soft tissue?

A

1540 ms-1

It is much slower than electromagnetic radiation

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10
Q

Define ultrasound

A

Sound of frequency above that which the human ear can hear

Any frequency above 20kHz

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11
Q

What is the average range of sound a person can hear?

A

20Hz - 17kHz
Some can achieve 20kHz
The upper end of the hearing range decreases with age or damage

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12
Q

What is the ultrasound range used in medical imaging?

A

2-15MHz
Most sound frequencies are not used clinically
These frequencies do not occur in nature

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13
Q

What are the consequences of increasing the frequency used for imaging?

A
Increased resolution
Decreased penetration 
Increased absorption
Increased heat
Increased intensity attenuation coefficient (mu)
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14
Q

What do you need to consider when choosing a frequency to use for imaging?

A

Depth of penetration - shallow penetration = high frequency
10-15cm needs 3MHz
Each scanner comes with a range of transducers for different uses and depths

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15
Q

What effect does ultrasound exploit?

A

Piezoelectric effect

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16
Q

What is the natural occurring substance that displayed the piezoelectric effect?

A

Quartz

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17
Q

What is the piezoelectric effect?

A

Applying a STRESS to a piece of quartz creates a VOLTAGE on it that is PROPORTIONAL to the STRESS

Stress creates charge/electricity
It turns mechanical energy into electrical energy

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18
Q

Describe the piezoelectric effect

A

Applying a voltage causes a change in shape
Varying voltage causes vibrations
Ultrasound echoes from the body cause an electrical signal
It is useful for generation and detection of ultrasound

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19
Q

Describe the production and detection of ultrasound

A

Production - excitation voltage is applied and the material deforms
Detection - echoes return exerting pressure which creates an electrical signal

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20
Q

What material is currently used for generation of ultrasound?

A

PZT
Lead zirconate titanate
New synthetic piezoelectric material
Ceramic

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21
Q

What is the advantage of using PZT?

A

Can make any shape
Ceramic material
Synthetic

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22
Q

How is PZT created?

A

Poured into a mould and heated above the Curie temperature
High voltage is applied
Leave voltage applied and cool

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23
Q

What can degrade PZT?

A

Mechanical damage - it is very vulnerable to dropping/breaking
Heating
Exceeding electrical limits

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24
Q

What is the pulse echo principle?

Use a diagram to explain

A

Assume speed
Measure time
Can then calculate distance
Distance = speed x time

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25
What are the problems with the pulse echo principle?
It assumes sound travels in a cone This is not the case in reality You do not know where the echo generating material lies
26
How are the problems with the pulse echo principle improved?
Using a narrower beam can give a better idea of where the echo came from You can get a better judge of distance Multiple small narrow beams provide more information
27
What are the assumptions of the pulse echo principle?
Propagation is in a straight line There is a thin beam Want a non diverging beam
28
What causes ultrasound artefacts?
Caused by the failing of assumptions | Machines are designed as if assumptions are true
29
Why is scanning bone and air problematic?
When there is a change in the speed of sound Bone is much slower (4080ms-1) Air is much quicker (330ms-1) Works well in soft tissue where the speed of sound is similar in many tissues (1540-1580)
30
How is the speed of sound in a material calculated?
Speed = square root of: stiffness/density Sqrt k/p K can also be referred to as elasticity
31
What is the most important component in determining the speed of sound in a tissue?
Stiffness It is more important than density Stiffness has a 3x greater magnitude than density Ultrasound is stiffness mapping
32
Describe what happens to ultrasound in the body | Use a diagram to explain
Body is complicated and has multiple reflectors A certain fraction of energy is reflected at each reflector Some carries on and it reflected later There are many echoes per pulse Each echo can be separated as they do not arrive simultaneously
33
What happens if you have a high reflector anterior?
It will cast a shadow
34
What is an A scan?
It is the raw data seen by the machine not the operator It is not a 2D image It is the measured signal This can then be converted to a spot with a brightness proportional to the signal amplitude
35
How is a 2D image generated?
Machine detects the signals Creates a spot with a brightness that is proportional to the signal amplitude Need multiple rows Need multiple transducers These are all in a line They are fired one at a time, to not confuse the signals
36
What is M mode?
Use one direction to represent time rather than space Displays depth vs. time Can measure velocities, minimum and maximum dimensions It displays motion Exclusive to echocardiography
37
What is time gain compensation (TGC)?
The largest signal (generally) will be from the first reflector Energy is lost as it passes through the tissue and because of reflection It would result in deep structures having a low signal without TGC It is controlled by the operator It can amplify echoes from specific depths
38
What is sound?
It is the transfer of mechanical energy from a vibrating source through a medium It is a mechanical wave and cannot travel through a vacuum It is a longitudinal wave
39
What would happen without TGC?
Deep structures would have low signal | Incorrect representation of the anatomy
40
What does TGC do?
Corrects for the loss of signal as the echo progresses It can create an artefact if done incorrectly Operator dependent
41
What can happen if TGC is applied incorrectly?
Creates an artefact | Noise is always present and it can create an echo where there isn't one by amplifying noise
42
What are the 5 tissue interactions?
1. Beam Spreading (diffraction) 2. Reflection 3. Scattering 4. Refraction 5. Absorption
43
Describe beam spreading | Use a diagram to do so
Beam maintains width of source to a point and then it starts to diverge Divergence point can be calculated NF = r^2/wavelength This creates a near field and a far field Ideally want a long near field
44
How do you calculate the length of the near field?
``` NF = r^2 / wavelength NF = near field 2r = width of transducer ```
45
How do you increase the length of the near field?
Increase the size of the transducer | Decrease the wavelength
46
What is focusing? | Draw a diagram
Using a lens in front of the transducer to focus the beam It will focus at the focal depth Lens is electronic
47
What is the consequence of focusing?
This creates a narrower beam but creates a larger divergence after the focal point Degrades the quality of the image Sharpens the image at the focal depth
48
When focusing what is the calculation to determine beam width?
BW = F x wavelength / A ``` BW = beam width F = focal depth A = aperature of transucer ```
49
What are the problems with focusing?
It degrades the quality of the image outside of the focusing depth Can focus at the wrong depth or use the wrong lens (poor operator) Operator dependent
50
How would you reduce beam width?
Increase the aperature (size of transducer) | Decrease the wavelength used
51
What is reflection?
It is essential for ultrasound It is not frequency dependent Reflection at a boundary depends on the change of acoustic impedance at the boundary Ultrasound signal is generated from boundaries It works well if 2 adjacent materials have similar Z values
52
What happens if gas in the beam?
Air has a very low characteristic acoustic impedance (Z) | Any gas will create a perfect mirror as all ultrasound is reflected back
53
How do you calculate acoustic impedance?
``` Z = pc Z = acoustic impedance c = speed of sound p = density ```
54
How do you calculate reflection correlation coefficient? R
``` R = reflected intensity / incident intensity R = (Z1-Z2/Z1+Z2)^2 ```
55
What is the R value between soft tissue and soft tissue?
R
56
What is the R value between soft tissue and bone?
R = 0.5
57
What is the R value between soft tissue and air?
R = 0.999
58
What is shadowing?
It occurs when a high proportion of the ultrasound beam energy is either reflected or attenuated by the target
59
When does shadowing occur?
Air/soft tissue interface Bone Calcification
60
What happens when the wave does not approach the boundary at 90 degrees? Use a diagram
The wave is reflected at an angle equal to the incident angle As the probe rotates it changes the image considerably
61
What is scatter?
It is critical in the blood Erythrocytes are perfect scatters - redirecting energy in all directions but weak The proportion of energy scattered is proportional to frequency^4 Causes an exponential decrease in intensity
62
When does scatter occur?
It occurs when the object is small compared to the wavelength It is highly frequency dependent
63
What is refraction?
When there is a change of speed of propagation and the beam is bent from its original path There is no significant change of speed between soft tissue Not a big problem in ultrasound
64
When can refraction occur and why does it cause problems?
It can occur when passing through muscle | Causes problems as the machine assumes the beam travels in a straight line
65
What is absorption?
BAD! Transfer of mechanical energy to heat Direct conversion of energy to heat All ultrasound creates heat Heat increases linearly with frequency In soft tissue, absorption accounts for >80% of total intensity reduction Causes an exponential decrease in intensity
66
What causes absorption to occur?
Frictional (visco-elastic) losses | Relaxation processes
67
What is the consequence of increasing frequency? Absorption
Increased absorption | Increased heat
68
Draw the graph the depicts the relationship between beam intensity and depth of penetration with varying frequency
Image
69
What is attenuation?
Occurs due to all interactions with matter | It is the loss of energy from the beam
70
What interactions with matter causes an exponential decrease in intensity?
Scatter | Absorption
71
What is the intensity attenuation coefficient? mu
The fraction of energy removed from a plane wave by the combined processes of absorption and scattering in unit path length it is tissue specific it is frequency dependent
72
What is the normal mu (intensity attenuation coefficient) in soft tissue?
1dBcm-1MHz-1
73
What are the reasons for a gynaecological ultrasound?
- Irregularities of the menstrual cycle - Congenital/structural abnormalities - Presence of a mass - Carcinoma (organ or origin or involvement of adjacent structures) - Presence of metastatic disease - Assisted contraception programmes - Intrauterine contraceptive device (IUCD localisation) - Screening program - Acute pelvic pain
74
What are the 2 methods for gynaecological exams?
Transabdominally | Transvaginally
75
How is the patient prepared for a gynae exam?
Bladder filling Drink 1 pint of water before hand It allows you to look through the bladder to the uterus
76
Describe the transabdominal technique for a gynae exam
Full bladder Longitudinal, transverse and oblique sections Contralateral technique Identify anatomical structures
77
What are the advantages of transvaginal technique for a gynae exam?
Transducer is closer to the area of interest Can use high frequency Increase the definition of the structure Increased quality of image
78
What observations should be made in a gynae exam?
The scan should demonstrate: - Normal anatomy/ varients - Assess size, outline, echotexture and echogenicity - Pathological findings
79
What are the normal variants that can be seen in a gynae exam?
Age and menstrual status related appearances of the ovary and uterus
80
Describe the different appearances of the ovaries depending on menstrual status
Image
81
Uterus examination - What should be examined - What is the normal appearance?
- Position - Size - Shape - Ultrasound characteristics of endo and myometrium - Centre of the uterus generates a linear echo - Uterus changes with cycle - Thickens from ovulation to menstruation
82
How can uterine perfusion be determined?
Using Doppler Blood flow to endometrium changes Can be useful in IVF
83
Ovary examination - what should be examined?
``` Position Size Shape Ultrasound characteristics Number and size of follicles Internal echo pattern of follicles They are small and hard to find - appearance changes with menstrual cycle ```
84
How does the size of the ovaries and uterus change with age?
Largest during reproductive years | Shrinks in menopause
85
How do you assess infertility by ultrasound?
Initial ultrasound is on day 10-12 of cycle Can use grey-scale US to assess Can use Doppler to assess blood flow of endometrium and ovaries Can use sonohysterography - Injection of contrast medium to assess uterine cavity and tube patency
86
What are the sonographic characteristic features of pelvic masses that should be considered?
Location and size Internal consistency Borders Ascites and other metastatic lesions
87
When looking at the location and size of a pelvic mass what features should be noted?
Unilateral - adnexal or intrauterine | Bilateral - pelvoabdominal or not defined
88
When looking at the internal consistency of a pelvic mass what features should be noted?
Cystic - homogenous, sepataed, solid foci, multiple cysts, multicystic Complex - predominantly cystic or solid Solid - mildly, moderately or markedly echogenic
89
When looking at the borders of a pelvic mass what features should be noted?
Well defined Moderately defined Poorly defined
90
Describe the appearance of polycystic ovarian disease
Over 12 follicles Follicles are small and never fully develop Due to abnormal hormone levels
91
Why use ultrasound?
``` Relatively inexpensive Patient friendly Safe in experienced hands No radiation 1st line examination for some presentations ```
92
What is the national screening program for obstetric US?
Scan in 1st trimester and at 20 weeks | Common practice - done in all pregnancies
93
What are the indications for obstetric ultrasound?
``` Placental site and abnormalities Uterine abnormalities Detection of a pelvic mass Foetal position Control for invasive procedures Detection of foetal compromise - monitoring of foetal wellbeing Foetal growth monitoring Estimation of foetal weight Amniotic fluid volume Medico-legal issues Client-consumer expectations Viability ```
94
What are the NICE guidelines around obstetric US?
Pregnant women should be offered an early ultrasound scan between 10 weeks and 14 weeks to determine gestational age and detect multiple pregnancies Ensures consistency of gestational age assessment and reduce the incidence of induction of labour for prolonged pregnancy Crown-rump length should be used to determine gestational age - once this is over 84mm, should use head circumference
95
What should the first obstetric screening scan establish?
Gestational age Viability (foetal heart beat) Foetal number Detection of abnormalities
96
In obstetric examination what features should be measured and when?
``` Mean gestation sac diameter Gestation sac volume Crown rump length 6-13 weeks Head circumference 13-25 weeks Femur length 13-25 weeks ```
97
What is foetal biometry?
Measurement of an anatomical parameter of a foetus | Estimate the age from the measurement
98
In foetal biometry what determines which areas are measured?
Reproducibility of the measurement | Correlation of the size to the age of the foetus
99
When and why is foetal biometry done?
Can be used to look for intrauterine growth restriction Can use Doppler to assess the umbilical artery Done in high risk pregnancies
100
What are the objectives of the foetal national screening program?
- Foetal anomaly screening (18-20wks) - Benefits outweigh risks - Reduce perinatal mortality by detecting malformations (requires a high level of expertise) - Reduce indications for induction of labour for post term pregnancy - Earlier detection of multiple pregnancies (improved management) - Earlier gestational age assessment
101
What features of the foetus need to be scanned at 20 week and what abnormality can it reveal?
- Head and Neck (brain and nuchal fold - Down's) - Face (lip - cleft palate) - Chest (4 chamber heart, outflow tracts, lungs) - Abdomen (stomach, abdo wall (omphalocele), bowel, renal pelvis, bladder) - Spine (vertebrae - spina bifida) - Limbs - Uterine cavity (amniotic fluid, placental site)
102
What percentages of abnormalities are picked up on foetal scanning?
Depends on the condition Anencephaly = 99% Cardiac abnormalities = 50%
103
What are the advantages of US in obstetric management?
- Detection of pregnancy at a very early age (4-5 weeks) - TV approach has increased sensitivity for detection of ectopic pregnancies - TV allows for detection of foetal movement from 5-6 weeks - Aids management of multiple pregnancies - Application of foetal biometry to reliable data - Aids management of complicated pregnancy - Diagnosis of congenital abnormalities
104
What are the 3 transducer array types?
Linear Curvilinear Phased
105
What does a linear array look like and what is it useful for?
Long flat front face Carotid artery Thyroid Breast
106
What does a curvilinear array look like and what is it useful for?
Curved face Fan Beam Obstetrics General abdominal
107
What does a phased array look like and what is it useful for?
Flat face Small area Cardiac
108
Why do you use a phased array for cardiac imaging?
It is difficult There is a small area for ultrasound due to the lungs and the ribs Small window requires a small transducer
109
How do you decide which transducer to use?
Choose the field of view that matches the area of interest THEN choose the frequency. If it is superficial use a higher frequency Operator determined
110
What are the specialist transducer types?
Transrectal Transvaginal Intraoesophageal
111
How do you calculate the minimum time required for one line?
2 x depth / speed 2D/C seconds
112
How do you calculate the time required for one frame?
2 x N x D / c N = number of lines per frame D = depth c = speed of sound
113
How do you calculate frame rate?
C / 2xNxD c= speed of sound D = depth N = number of lines per frame
114
What can you do to increase the frame rate?
Decrease the number of lines in the scan | Decrease the depth
115
How many frames per second is required to get a real time image?
20-25fps | If it is lower you get a jerky image
116
``` How many lines will be in the image using: Frames per second = 25 c = 1540ms-1 depth = 10cm Describe the resultant image quality ```
``` N = C / FR x 2 x D N = 1540 / 25 x 2 x 0.1 N = 308 lines ``` This will give a poor image - there is not enough time to get an adequate number of lines
117
What can you do if there is not enough time to get an adequate number of lines?
Can use false frames | Only if the image is not moving quickly
118
In what situations can you not use false frames?
Liver, cardiac, kidney | when the object is moving quickly
119
How are false frames created?
Uses linear interpolation - Can miss very small features - Must not detect a depth that is too much as you are throwing away information
120
Describe the interconnecting components of a B scanner using a flow diagram
Image
121
What is the clock in a B scanner?
It sends sychronising pulses around the system It instructs the pulses of the ultrasound Each pulse corresponds to a command to send a new pulse from transducer It determines the pulse repetition frequency It communicates with the transmitter,TGC generator and Beam controller Need to wait for echo to return before sending out the next pulse
122
What is the pulse repetition frequency?
PRF The rate of ultrasound pulse generate (kHz) NOT US FREQUENCY (MHz)
123
How do you calculate PRF?
PRF = 1 / time per line PRF = speed / 2 x depth
124
What is the transmitter in a B scanner?
Responds to clock commands by generating high voltage pulses to excite the transducer It is housed very closer to the transducer (likely to be within it) It causes the transducer to vibrate/oscillate to create the sound
125
Where is the transmitter, why?
Housed very close to the transducer (likely to be within in) | This reduces time and ensures there is no loss of voltage
126
How is an ultrasound created? (different components involved)
Clock instructs the transmitter Transmitter creates a voltage Voltage creates an oscillation in the crystal
127
What is the ADC?
Converts analogue signal into digital signals for further processing Once digitised, everything else is software Receives analogue signals from the transducer Transmits digital signals to the signal processor
128
What are the required properties of the digitisation rate?
- Be fast enough to cope with the highest frequencies - Have sufficient levels to create an adequate grey scale e.g. 1024 - Be higher than frequency so as not to lose information - Can be fast or have lots of levels
129
What is the signal processor?
It is different for each manufacturer. The digital signal from the ADC is passed to the signal processor.
130
What are the 4 functions of the signal processor?
TGC Application Overall gain Signal compression Demodulation
131
What is TGC?
Time gain control | Applying different gains at different depths set by the operator
132
What is overall gain?
Treats all echoes equally as all echoes are small and need extra amplification
133
What is signal compression?
Returning echoes have a wide range of amplitudes and these should be represented by different grey values Signals converted to a grey levels
134
How do you calculate dynamic range?
Largest signal level below saturation / smallest signal level above noise.
135
What is the dynamic range?
It is the ratio of the largest to the smallest signal Usually expressed in decibels Range 10uV to 1V
136
What limits the largest signal in US?
Saturation - it a signal goes above the saturation point it is viewed as the same colour as the maximum
137
What limits the smallest signal in US?
Noise - signal will not be displayed if it is below noise
138
What is a decibel?
It is a relative unit 1 dB = 10log10 (p1/p2) x compared to y
139
Describe the relationship between power and voltage
Power is proportional to voltage squared 1dB = 10log10 (v1/v2)^2 1dB = 20log10 (v1/v2)
140
What is the normal dynamic range? | What is the dynamic range of a display?
Generally around 100dB There is a massive ability to distinguish different sounds Typical monitors have DR = 25dB
141
What is the problem when displaying signals?
They are converted to a grey scale Lose a lot of information Displays are not good enough to display all sound levels Brains cannot distinguish all of the subtle differences
142
What are the 2 methods for assigning grey levels to echo amplitudes?
Linear | Transfer curves
143
Describe linear assignment of grey levels to echo amplitudes
Divide range into equal segments in a linear fashion | Problem: all small signals are assigned a grey scale level one and you lose all contrast resolution for small echoes
144
What is the use of transfer curves?
Assigning grey levels to echo amplitudes | Optimise the curve to the clinical requirement
145
Describe transfer curves - draw their typical appearance
Image Curve 1 - using most grey scales for lower echoes Curve 3 - lost information for small echoes and use more grey scales for higher echoes Machines have presets Loads curve that is best for a particular application Different curves for different manufacturers
146
What are the X, Y and Z values for imaging?
X and Y are positional information and this comes from the beam controller Z value is the grey scale level
147
What is the function of the image store?
Takes Z (brightness) signal from the processor Positions it in the image memory using the X and Y information from the beam controller Assembles an image for each frame Presents assembled image to display
148
How many images can be stored?
100-200 images/frames on a cineloop
149
How are the X and Y co-ordinates determined by the beam controller?
X value - depth determined by timing and speed of sound assumption Y value - distance from the edge of the array at which the pulse was launched
150
What is pre-processing and what does it include?
Anything which is done to the signal prior to storage in the image memory It is DESTRUCTIVE (cannot be undone) Includes TGC, depth scale, compression
151
What is post-processing and what does it include?
Anything which is done to the image/signal AFTER storage in the image memory It is non-destructive Includes: alpha numerics, calipers, black and white inversion, read zoom Can be scaling or transfer function
152
What is frame averaging?
In any frame, some of the information displayed will be noise It removes unwanted signal and decreases the noise errors It will pick up any noise in the environments Taking the maximum or minimum value (rather than averaging) will emphasise noise.
153
Where are the sources of noise?
electronics, acousitc, environmental | Noise is expected in every frame because of the random nature
154
What happens as you increase the number of frames averaged?
Decreased noise errors
155
What happens as you increase the number of frames in frame averaging?
Increase time Slower to respond to genuine changes Lose some information relating to movement Trade off between frame rate and noise reduction (incorporated into machine presets)
156
Describe the function of the transducer
Sends out short ultrasound pulses when excited electrically | Detects returning echoes and presents them as small electrical signals
157
What is the effect of decreasing transducer size?
Decrease near field | Increase lines
158
What are overlapping groups?
Partial solution Fire several elements together Electrically connect a block of transducers 1 pulse = several transducers fire Move down by one element e.g. 1-7 then 2-8 etc. Repeat but block size is maintained Mimics the effect of a large source but produces multiple lines SYNTHETIC APERTURE
159
What is the advantage of using overlapping groups?
synthesises an artificially larger transducer Increase near filed as N^2 Usual element size is 1mm and this creates a short NF Extends this
160
What is array focusing? | Use a diagram
It introduces delays to compensate for the extra path length of the outer elements Increases the delay at central transducers At an arbitrary point, signals will arrive at the same time You choose that point This is done on transmission and reception Same effect as a lens Increases the quality at a specific depth
161
Why is array focusing necessary?
Waves from outer elements have greater path lengths - therefore signals do not arrive simulateously at the target - Reflections from the target do not arrive at all elements at the same time - Blurring on way in and way out
162
What are phased arrays?
``` Can direct beam off all axis Can use all the elements each time Can fire beam at any angle by changing delays No stepping along the array Small sources ```
163
What is multizone focusing?
Focusing makes the image worse at other depths Instead of moving the array down - send out beams at different time delays Start collecting echoes after the cross over point Multiple beams Creates multiple images with various foci which are then combined
164
What is the consequence of multizone focusing?
Increases the quality of the image | Increases time
165
How many focal zones should be used?
Operator needs to put in as many zones as possible but keep the frame rate high enough to detect movement Many in breast, few in cardiac
166
When is multizone focusing used?
Linear | Curvilinear
167
Draw a diagram to explain multizone focusing the the composite focus that can be achieved
Image
168
What is the effect of increasing the size of the lens aperture?
Smaller beamwidth Depth of focus is reduced Determined by the manufacturer
169
What are the 3 resolution orientations?
Axial Lateral Slice thickness
170
Describe axial resolution
It is the resolution in the direction parallel to the direction of the beam The resolution along any point of the beam is the same Depends on pulse length
171
What is the effect of increasing the frequency on axial resolution?
Increasing frequency = decreased wavelength | This gives increased axial resolution as there are shorter pulses
172
What pulse type gives the best axial resolution? Use a diagram
Short pulse
173
What causes an increase in axial resolution?
Increase frequency Decrease wavelength Decrease the number of cycles in a pulse
174
Describe lateral resolution
lateral resolution is defined as the ability of the system to distinguish two points in the direction perpendicular to the direction of the ultrasound beam It depends on beam width The object is viewed as wide as the beam width
175
Draw a diagram to show the effect of beam width on lateral resolution
Image Object is viewed as wide as the beam width Increasing beam width = decreased lateral resolution
176
What is the effect of increasing beam width on lateral resolution?
Decreased
177
What determines beam width
``` Shape and size of transducer Depends upon the focusing BW = F x wavelength / A F = focal length. A = aperture As frequency goes up, the wavelength goes down = beam width goes down = lateral resolution increases ```
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How do you increase lateral resolution?
Decrease beam width by: Increasing frequency Increasing the size of the aperture
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Describe slice thickness
It depends on the thickness or height of the beam Normally poor as there is no electronic focusing Decreases as frequency increases Usually the worst resolution
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How can improve resolution in the slice thickness direction
1.5/2D arrays improve focusing and resolution Can focus the beam in 2 planes Can send a beam out in any direction
181
What is Doppler?
The technique of using ultrasound to measure flow. Have increase in frequency when direction is towards observer and decrease when it is away.
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When does the Doppler effect occur?
When either the receptor or the generator is moving relative to the other If there is no movement the frequency emitted it equal to the frequency received
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What happens in Doppler if an object is moving towards the observer?
Moving source - stationary observer Increase pitch Increase frequency Waves are squashed in the direction of travel.
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What happens in Doppler if an object is moving away from the observer?
Decrease frequency | Waves are stretched
185
What is the result of having a moving observer with a stationary source?
Also get a Doppler shift. | If the person is moving towards the source then it picks up waves more rapidly causing an increase in frequency
186
What causes an increase and decrease in frequency in Doppler?
Motion towards = Increase frequency | Motion away = decrease frequency
187
Describe the Doppler effect in the body
- Sound is transmitted to the blood and will irriadiate the RBCs - They are moving - The frequency the RBCs receive different to sent out - They scatter the signal in all directions - The backscattered shifted signal is sent out in all directions First there is a stationary source (transducer) and moving receiver (RBC) Then the RBC acts as a moving source and the transducer becomes the stationary receiver
188
What is the result of the 2 doppler effects in the body?
They do not cancel each other out - it is doubly shifted.
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What is the doppler shift frequency?
Doppler shift (delta f) It is the difference between the received frequency (fr) and the transmitted frequency (ft) Change in frequency of the echo due to the motion of the target
190
How do you calculate Doppler shift frequency? (delta f)
``` cos(angle) x 2 x ft x v / c ft = transmitted frequency c = speed of sound v = target speed 2x due to the double Doppler shift angle = angle between the beam and flow ```
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Why is Doppler done at an angle?
No Doppler shift occurs if it hits at 90 degrees Ultrasound is generally done at 90 degrees to not get a signal from blood Maximal Doppler shift is at 0 or 180 degrees Need to know the angle used
192
What is colour Doppler?
- Superimpose the Doppler information on top of the underlying grey scale image. - Use colours to represent the Doppler shifts
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What is are the principles of colour Doppler?
- Repeated firing along one scan line - Compare lines in consecutive pairs - Divide each line into segments - Compare segment by segment - Use frequency content of each segment - 6 or 8 samples down each line - Look at the similarities and differences between the pairs - If the segments are identical = no Doppler shift
194
What is displayed in colour Doppler?
Superimposed colours on greyscale image Doppler shift frequency is not displayed Displays PHASE Measure phase difference
195
Describe the rate of change of phase in colour Doppler
Frequency = rate of change of phase = Speed
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How is colour mapping done in colour Doppler?
Colour indicated direction: Blue Away Red Towards Blue - movement away from transducer Shade = velocity Variance - how wide spread are the velocities? Colour options: hue, brightness, saturation
197
What colour is given to turbulent blood flow?
Green/yellow
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What is Doppler priority?
- Determines whether to display colour or grey scale - If the grey level is large enough, a colour is not put there - If the grey level is less than the threshold value then display colour - The decision is arbitrary - If there is a large signal e.g. from a boundary then you want it to be displayed
199
What decides whether to use the B signal or Doppler signal?
Blood/tissue discriminator | The discrimination point is determined by the operator - Doppler priority
200
Where is the change of phase calculated?
Autocorrelator
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How is the area determined for colour doppler imaging?
Operator places a box over the region of interest This instructs the machine to look in that area to determine Doppler effect Keep the box as small as possible
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What happens if you increase the size of the box for viewing colour Doppler?
Increase size of box = decreased frame rate due to increased lines
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What is power Doppler?
More sensitive than normal colour but does not give the velocity information
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What are the differences between colour Doppler and power Doppler?
In Colour - the values collected are sorted into velocity bins. Anything below noise will not be detected - any components are not represented strongly will not be detected Power Doppler - all values placed into one bin. The one value bin is way above the noise level
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What are the advantages of power Doppler?
- Better signal to noise ratio - Better at picking up low volume flow - Better for peripheral areas and areas of low flow e.g. stenosis - Powerful sensitivity - Insensitive to Doppler angle
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What are the disadvantages of power Doppler?
- Gives no velocity estimate - may not have directional discrimination (no idea if negative or positive flow) - has no measure of turbulence - no quantification
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What does tissue Doppler do?
Suppresses blood flow, looks at the movement of vessels. It is colour Doppler set up slightly differently. ``` Turn down Doppler gain Use low pass filter - to supress blodd Removes the wall thump filter Displays colour on vessel walls Detects tissue motion ```
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When is tissue Doppler used?
Used for low velocities | Used to view the vessel walls
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What is a wall thump filter?
Vessels move slower than blood If the velocity is less than X then remove Applied by this high pass filter Suppresses detail from blood flow.
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What is continuous wave Doppler?
It is the purest form of Doppler Permanently emitting and receiving - separate send and receive transducers are used It provides a snap shot of what is happening in the vessel
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What are the advantages of continuous wave Doppler?
Simple Cheap High quality spectral information available
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In continuous wave where are the reflections from?
Stationary targets e.g. organ boundaries | Slow moving large targets e.g. vessels walls
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What is the purpose of continuous wave Doppler?
Need to filter out clutter signal
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Describe the velocity distribution within the blood
Blood moves with a range of velocities The velocity distribution changes with time Flow is pulsatile You get different appearances at different points in the cardiac cycle
215
Draw a diagram depicting continuous wave Doppler
image
216
What does the continuous wave Doppler spectrum display?
It displays the range of velocities along the x axis It displays the delta f (Doppler shift frequency) along the y axis At each time point there is a range of velocities present and their relative intensities The orange/brown colour is used to display intensity It details systole and diastole Shows peak velocity
217
What are the advantages of continuous wave doppler?
Shows lots of detailed information Each artery has a different Doppler spectrum Very sensitive to pathology but requires an expert
218
What is the key error that can be made in continuous wave doppler?
Ignoring the angle | Changing angles changes the spectrum
219
What are the the problems with continuous wave doppler?
``` Do not know vessel angle May have overlying vessels Do not have an image No depth discrimination Requires an expert Need to be certain of anatomy ```
220
What are the uses of continuous wave Doppler?
Need to be certain of anatomy 1. Check for vessel patency in vascular surgery 2. Foetal heart detection 3. DVT detection
221
How does pulse doppler work?
``` Uses long pulses NOT continuous waves Approximately 6-7 cycles Have gating to select depth Can have an associated image Pulses give depth information ```
222
What are the features of pulse doppler?
``` Everything is compromised Poorer axial resolution Can distinguish overlying vessels Too short for frequency information but also lose spatial information Can get a pressure ```
223
What is the main disadvantage of pulse doppler?
Aliasing
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What is aliasing?
Undersampling can lead to a misleading image | Limit for aliasing = Nyquist theorem
225
What is the maximum doppler shift you can detect without ambiguity?
Less than PRF/2 | If PRF = 1kHz, can’t detect doppler shift greater than 500Hz
226
What is the Bernouilli equation?
p1-p2 is approximately equal to 4V^2 p1-p2 = pressure gradient v = peak velocity at narrowing If you can measure the peak velocity, can non-non-invasively calculate pressure change over a pathology.
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What are the advantages of pulse doppler?
Depth information Can combine with an image Good spectral infromation
228
What are the disadvantages of pulse doppler?
Aliasing Need to know where to look Can only look at one place at once
229
How is stenosis viewed using ultrasound?
Is it characterised by high pressure gradients across the narrowing Use colour doppler first then guided pulse doppler to get spectral information Using pulse doppler can get pressure and the pressure difference is related to the density and velocity of fluid movement in the vessel.
230
Describe a transducer
They are a resonant device They have a natural frequency The thickness of each element in the housing depends on the wavelength Range from 3-10MHz
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How is the transducer thickness determined?
Thickness = wavelength / 2
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What happens to the frequency as you decrease transducer width?
Increase frequency
233
Draw a diagram of the transducer including its layers.
Image
234
What are the different layers of the transducer?
``` Backing material Electrodes - the transducer has electrodes evaporated onto the transducer. Transducer Electrodes Matching material ```
235
What is the purpose of the transducer backing material?
Dampens the resonance | Allows you to control the pulse (very short) to get better axial resolution
236
What happens to axial resolution as you decrease pulse length?
Increase axial resolution
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What does the transducer backing material do?
Absorbs some of the sound to dampen oscillation | Needs to allow sound in readily but stop it leaving
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What are the important features of the transducer backing material>
Needs to be a good absorber Needs a high absorption coefficient Needs to have a similar Z value to that of the transducer ZT= ZB
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What is the consequence of increasing the high absorption coefficient of the backing material?
It makes the transducer less efficient | Heats during use
240
What is the purpose of the matching material in the transducer?
Gets the energy out of the transducer and into the patient
241
What is the Z value (acoustic impedance value) of the matching material?
Halfway between the Z of the patient and the transducer Zm = SQR (ZT x Zpt) ZM = acoustic impedance of matching material ZT = acoustic impedance of transducer Zpt = acoustic impedance of patient
242
What materials are the backing and matching materials made out of?
Unknown | Different in different manufacturers
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A backing material NEEDS:
to have a high value of attenuation to be well matched to Z of PZT but it reduces sensitivity and efficiency
244
A matching material NEEDS:
to have a Z value matched to transducer and patient | this will always be a compromise
245
What is the optimal thickness of the matching material?
approximately 1/4 of the wavelength
246
What are the features of PZT composites?
Have other materials included to reduce Z value and increase efficiency Allows for use of multi-frequency transducers Capable of being used away from optimum frequency
247
What is the main feature of a continuous wave transducer?
Transducers for CW only do not need a backing material - does not use pulses This makes them very efficient and sensitive.
248
What does a Fourier analysis do?
Involves breaking down a signal into its component parts.
249
Draw a continuous wave and its fourier analysis
image One fixed frequency Fixed amplitude No width in Fourier analysis - single line
250
What are the features of a pulsed wave?
Varies in amplitude Contains a range of frequences Complicated in shape Fourier analysis shows a spread of frequencies
251
Draw a long pulsed wave and its fourier analysis
image similar to continuous wave but there is a spread of frequency Narrower range of frequencies than short pulse
252
Draw a short pulsed wave and its fourier analysis
large range of frequencies | wider bandwidth
253
What happens to bandwidth as you increase pulse length?
Increase pulse length = decrease bandwidth
254
What is the impact of attenuation on bandwidth? | Diagram
High frequency components are attenuated MORE than low frequency components - Tissue attenuation is frequency related - As it travels through the tissue it changes - Change in frequency content and change in shape of pulse Image
255
What are the consequences of attenuation on the shape of the beam?
Reduction in bandwidth Decrease in central frequency Same process as beam hardening
256
Draw the pulse and fourier analysis for a typical B mode image. What are the features?
Wideband Good spatial resolution Increased axial resolution due to wide bandwidth
257
Draw the pulse and fourier analysis for a typical colour Doppler image. What are the features?
narrowband Medium spatial resolution Better control of frequency (therefore better for Doppler)
258
Draw the pulse and fourier analysis for a typical spectral power Doppler image. What are the features?
Narrowband Poor spatial resolution Pulse wave 7-8 cycles Decreasing bandwidth from B mode and colour.
259
Draw the pulse and fourier analysis for a typical continuous wave image. What are the features?
No pulse No axial spatial resolution Image 250
260
Describe the beam as it passes through tissue in areas of high and low pressure
- As the beam is travelling through tissue it is changing shape - Momentarily there are changes in pressure and alters the tissue and the speed of sound - Slope rotates clockwise - Tissues causes non-linear distortion of the beam - High pressure = tissue compressed, higher velocity - Low pressure = tissue expanded, lower velocity
261
What causes the non linear distortion of the beam in tissue
High energy/ amplitude of the beam | Distortion increases on the return journey back to the transducer
262
Draw a normal wave and a distored wave and their fourier analysese
Image | Peaks in distorted are multiples of the original frequency e.g. f, 2f, 3f
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What are harmonics>
Peaks that are multiples of the frequency f, 2f, 3f etc. of the original frequency Part of the wave is coming back at higher than the frequency sent out
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What is harmonic imaging?
Send out a wave at frequency f Measure frequency returned at 2f Harmonics are generated in the tissue - creates better resolution
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What are the advantages of harmonic imaging?
- Reduces clutter due to artefacts (a lot of clutter is low amplitude and doesn't contain much 2f) - Improved spatial resolution - Increased contrast
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What are the disadvantages of harmonic imaging?
Reduced dynamic range | Reduced penetration
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What are the 2 methods for applying harmonic imaging?
2 main methods - filtering - pulse inversion Each manufacturer does it slightly different
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Describe filtering as a method for applying harmonic imaging? Diagram
- Divide the bandwidth into 2 and use the low end for transmission and the upper end for reception - Makes smarter use of bandwidth available - Excite at below the resonant frequency - Put in a filter and filter out anything but 2f
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What are the consequences of using the filtering method apply harmonic imaging?
Bandwidth is reduced therefore pulses are longer Degrades axial resolution Improved lateral resolution at the expense of axial. (Axial is better so can lose a bit more)
270
Describe pulse inversion as a method for applying harmonic imaging
- Send out 2 pulses, one of which is the inverse of each other - Add them together - Expect A+-A = 0 if they are symmetric - However distortions are not symmetric and harmonic is left behind - Assume symmetry - not true to do non-linear propagation. - The inverted pulse is distorted differently to the original - Pulses cancel out but the echoes do not - Summing up of echoes gives 2f
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What are the advantages and disadvantages of using pulse inversion for harmonic imaging?
- Uses short broadband pulses - No degradation to axial resolution - Frame penalty - have to send out 2 pulses
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Which is the better method for harmonic imaging?
Both work well and achieve objectives with different costs - If frame rate is a problem do not use pulse inversion - Cardiac uses filtering - Most others will use pulse inversion and accept a slower rate
273
What is the purpose of contrast agents?
It makes an area visible that was not previous visible | They attempt to map function in a way that raw imaging does not
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What contrast agent is used in ultrasound?
Small encapsulated gas bubbles. - Injected into the blood stream - Administer small amounts in a controlled environment - Give a large echo
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How is signal enhanced using gas bubbles?
1. They have a strong acoustic impedance mismatch (Z in air is low, low density and speed of sound. Relative to soft tissue there is a large difference) 2. At some point frequencies are RESONANT and this provides further enhancement (x1000) (If the bubble is hit with the right frequency you will get a large increase in the quality of the signal 3. Have more non-linearity than soft tissue and can therefore be detected using harmonic imaging
276
What are the features of the contrast agent used?
- Agents travel through a peripheral vein through the blood by encapsulating - It is stabilised by an outer shell - Use heavy inert gases to increase life time
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What is the purpose of the shell around the gas in a contrast agent?
It is stabilising | Creates a longer half life
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Why do you use a heavy inert gas in bubbled?
Creates an extended bubble life | Less diffusion out of the shell
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What is the mean size of a bubble?
1-6 micrometerres
280
What gases are used in bubbles?
Air Octofluoropropane Nitrogen
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What chemicals are used for the bubble shell?
Albumin Lipid/surfactant Polymer
282
Give an example of a microbubble contrast agent
Albunex Definity Sonovue
283
What determines what happens to the bubbles?
Pressure in the pulse
284
What are the 3 options that can happen with bubbles?
Linear oscillations Non-linear oscillations Transient scattering/ bubble destruction
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Describe linear oscillations with bubbles
Occurs at pressures
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Describe non-linear oscillations with bubbles
- Occurs at pressures above 50kPa - Arise primarily from contrast agent in blood as the bubbles exhibit stronger non-linearity - Harmonic generation is minimal in tissue - Work in this area when working with contrast agents
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Describe transient scattering/ bubble destruction when working with bubbles
Occurs at pressure over 1MPa | As intensity increases, the shell becomes leaky and will eventually burst releasing free microbubbles
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What is MI?
Mechanical index | Related to the pressure of the singal
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What MI does linear oscillation occur?
0.006-0.06 MI (3MHz) | 10-100kPa
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What MI does non-linear oscillation/harmonic generation occur?
0.06-0.6 MI (3MHz) | 100kPa-1MPa
291
What MI does bubble collapse occur at?
0.6-6 MI (3MHz) | 1-10MPa
292
When using contrast agents what considerations need to be made?
- Bubble size - Gas content - Encapsulation - Administration - Detection
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How do you calculate the resonant frequency of an UNencapsulated bubble?
``` f = 3.3/r r = bubble radius (micrometres) f = resonant frequency (MHz) ``` Encapsulated bubbles are more complex
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What frequency will a bubble with a 2um diameter resonante?
``` f = 3.3/1 f = 3.3MHz ```
295
What happens to resonant frequency as bubble diameter decreases? Draw relationship
Higher resonant frequency
296
What is the maximum size of bubble? Why?
Nothing over 10 micrometres | Large bubbles will be trapped in the lungs and cause emboli
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What determines the choice of gas?
Normally: air or heavy gases like perflurocarbon or nitrogen. - Heavy gases are less water soluble so they are less likely to leak out from the microbubble to impair echogenicity - Heavy gases last longer in circulation - Choice does not matter acoustically - Needs to be non-toxic
298
What determines the material of encapsulation?
- currently: albumin, galactose, lipid or polymers - The more elastic the material the more acoustic energy it can withstand before bursting - BUT stiffer shells generate more harmonic signals - Behaviour on compression is different from behaviour on expansion - If the pressure is too great the surface tension can't support the bubble and BUCKLING occurs (depends on shell material)
299
How are the bubbles administered?
Normally venous either bolus or slow transfuction - Have multiphasic response - Can use a destruction pulse to temporarily clear a region and monitor re-population (useful for diagnosing metastases)
300
What is the advantage of bolus administration of contrast agent?
Can watch tissue or organ dynamics | Plot wash in and wash out curves
301
What is the advantage of slow transfusion administration of contrast agent?
Look at steady state response | Image over several frames to identify regions of high/low uptake
302
How is contrast agent detected?
Use harmonic content of back-scattered bubble Use enhanced Doppler signal since the bubble is moving and backscatter from the bubble is larger than from RBC
303
What are the specific clinical applications of contrast agents?
- Study of transcranial and neck vessels - Contrast echocardiography - Liver imaging to detect portal hypertension and thrombosis - Oncology
304
Describe targeted ultrasound
- Microbubbles are targeted with ligands that bind to certain molecular markers that are expressed by the area of imaging interest or by direct binding to the cell of interest - Microbubbles travel through the circulatory system, finding respective targets and binding - If a sufficient number bind they become visible - Place part of a binding pair on the surface of the bubble
305
What are the potential uses of targeted ultrasound?
- Tumour marker - Attach a chemotherapeutic agent in/on the bubble and use high energy ultrasound to burst the bubble - Agent is released and enters tumour via sonoporation
306
What are the challenges faced using contrast agents?
- Life time in blood stream - Adhesion/specificity - Unwanted immune response - Toxicity - No toxic biproducts
307
What are the advantages of ultrasound?
- Safe - Well tolerated - Relatively low cost - No ionising radiation - Few technical limitations - Patient friendly (no claustrophobia) - Metallic implants not a problem - Better for real time dynamic studies
308
What are the limitations of ultrasound?
- Highly operator dependent - Requires in depth anatomy knowledge - Limited in joint assessment (intra-articular not viewable) - Bad for knee and hip
309
What transducers are used in MSK US?
7-17MHz linear transducers High frequecy Can use curvilinear if you need to see a mass or deeper structure
310
What are the different ways of viewing MSK in US?
- Panoramic - wide field of view. Builds up as you go across - Dual screen (allows you to compare one normal image with pathological sample) - Power/colour Doppler (is sensitive and is good in rheumatology. A lot of masses will have vascularity. Can tell if pt has synovitis.)
311
What structures can you view using MSK US?
``` Joints Tendons Muscles Bones (cortical surface) Ligaments Bursae Nerves ```
312
What are tendons?
Attach muscle to bone Fascicles type 1 collagen, orientated mainly parallel to the long axis Covered in paratenon and epitendineum If they need more movement they are in the synovial sheet
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How do tendons appear on US?
echogenic fibrillar structures multiple parallel lines in longitudinal section multiple dots on transverse section
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How does the synovial sheet of tendons appear on us?
thin echogenic fluid containing structure that surrounds the echogenic tendon
315
How do nerves appear on US?
Looks very similar to ligaments and tendons Facicles are more spread out Hypoechoic group of fascicles Have perineurium and epineurium (echogenic)
316
Describe the strucutre of muscles
Muscle fibres are grouped into fascicles separated by septa of fibroadipose tissue (perimysium) Whole muscle enclosed in a fascial sheath (epimysium)
317
What do muscles look like on US?
Transverse perimysium is seen as dot echoes or short lines scattered throughout hypoechoic background Large intramuscular septa are echogenic Produce a reticular pattern Intermuscular septa are brightly echogenic
318
Describe the appearance of a contracted muscle
Muscle alters shape and becomes hypoechoic and increased angulation of echogenic septa
319
How are muscles/tendons/ligaments imaged?
Imaged at stress and in extension. It can look pathological if not State alters echogenicity
320
What can be viewed in joints?
Cartilage Synovial fluid Joint Capsule Fat pad
321
What is the main artefact seen on MSK US?
Anisotropy It can make tendons look pathological This is the effect that makes a tendon appear bright when it runs at 90 degrees to the ultrasound beam, but dark when the angle is changed. Need to scan at appropriate angle
322
What is the role of MSK ultrasound?
- Rheumatoid arthritis and joint disease– management of the disease, small joint assessment - Soft tissue masses, lumps and bumps, hernias - Sports medicine – muscle tears, sprains, athlete rehabilitation - Trauma – muscle tear, tendon rupture - Age related degenerative changes – rotator cuff disease, osteoathritis
323
What are the pathologies seen most commonly in MSK US?
- Tendon tears - Tendinosis - Tenosynovitis - Joint effusions/bone erosions from RA - Bursitis, ganglion cysts, lipoma, muscle tears, nerve masses, ligament sprains History taking can aid diagnosis
324
What interventional procedures can be guided by US? (MSK)
- Joint aspirations - Therapeutic steroid injections - Biopsy of masses - Nerve block
325
What are the 3 mechanisms in which ultrasound can cause damage?
Cavitation Microstreaming Heating
326
When is cavitation most significant?
- Concerned with activity of small bubbles when exposed to ultrasound - Most significant when using large pressures and low frequencies - Important close to gas collections (lung)
327
Describe cavitation
- Dissolved gases in the surrounding area diffuse into bubbles under positive pressure (positive half cycle) - Negative half cycle = expands and some gas diffuses out - Negative half cycle is more efficient at moving gas - In a complete cycle the bubble will grow and have less gas within it At the end of the pulse everything goes back to normal (not a problem with a short pulse) In a long pulse, pressures become so great that the bubble cannot be supported by surface tension and will collapse inwards - dangerous
328
Why is cavitation not important?
It does not take place in vivo with diagnostic US levels. | Oscillations at lower levels can cause change in micro-circulation and alter cell permeability
329
When is ultrasonic heating most important?
All procedures causes heating due to the deposition of energy. Normally most significant in pulsed or colour Doppler.
330
Why is heating greatest in Doppler?
Exposure is either continuous or with long pulses | There is also repeated firing down one line
331
At which interface does the greatest ultrasonic heating occur?
Soft tissue - bone interfaces | Strong reflection and as a result lose a lot of energy here.
332
What determines the rate amount of ultrasonic heating?
Depends on the time averaged intensity and/or power.
333
What are the safety indices?
MI - mechanical index | TI - thermal index
334
What is the MI?
Mechanical index Risk of cavitation damage Advised to keep below 0.3 (no adverse data below 0.3)
335
What is the TI?
Thermal index | Risk of thermal damage
336
How do you calculate the mechanical index?
MI = p/ sqrt (f) ``` p = peak negative pressure (MPa) f = frequency (MHz) ```
337
How do you calculate the thermal index?
TI = power emitted/W deg Wdeg = power required to raise temperature by 1oC Ratio of total power to Wdeg Keep below 0.5 Any increase in temperature of a body part by 1.5 degrees is fine
338
Is ultrasound safe?
No one has ever shown to have been damaged by a diagnostic ultrasound examination
339
Where can safety advice for US be found?
BMUS website
340
What is the BMUS advice regarding an MI >0.3?
There is a possibility of minor damage to the neonatal lung or intestine. Try to reduce exposure time as much as possible
341
What is the BMUS advice regarding an MI >0.7?
There is a risk of cavitation if an ultrasound contrast agent is being used containing micro-spheres. Risk increases with MI values above this threshold
342
What is the BMUS advice regarding an TI >3.0?
Scanning of an embryo or foetus is not recommended however briefly
343
What is the BMUS advice regarding maximum exposure time and TI?
``` TI = 0.7 max time = 60min TI = 1.0 max time = 30min TI = 1.5 max time = 15min TI = 2 max time = 4min TI = 2.5 max time = 1min ```
344
What is good practice for US safety?
- Use maximum receiver gain and minimum output power to achieve diagnostic image (gain does not affect MI or TI) - Avoid pulsed Doppler in early pregnancy in early pregnancy unless critical - Minimise dwell time - Do not perform scans with no clinical justification - Ensure that operators at adequately trained
345
What is the basic principle of elastography?
Apply stress (cause) and measure strain (effect)
346
What is elastography?
Imaging technique for soft tissue stiffness assessment An imaging technique whereby local axial tissue strains are estimated from differential ultrasonic speckle displacements
347
Why is elasticity imaged?
Changes in elasticity are generally correlated with pathological phenomena Equivalent to palpation
348
How to you calculate stress?
``` Stress = F/A F = force A = area Stress = pressure ```
349
How do you calculate strain?
Change in length/original length Fractional change in length of the material
350
How do you calculate Young's modulus?
E = Stress/Strain Units = same as those of pressure Young's modulus = stiffness
351
Why is Young's modulus useful?
Abnormalities have different Young's modulus values Increase in tumours
352
What are the 3 steps in elastography?
1. Generation of a low frequency vibration 2. Imaging 3. Elasticity estimation
353
How is elastography done?
Image of tissue - store Push transducer harder - store image Comparing the 2 images will show resultant strain due to tissue deformation
354
How is stress measured?
A fully compliant stand-off later (of known EM) is introduced It allows free passage of ultrasound waves Simultaneous measurement of strain in this layer enables calculation of axial stress distribution
355
How is strain measured??
1. A scan performed without compression 2. Slight compression with the probe 3. Cross correlation - compare the 2 A scans. Produce a map along the A scan and repeat for different lines
356
What are the different methods of applying force for elastography?
- Manual static pressure - Internal pressure (cardiac, respiratory - useful for liver can use breathold) - External dynamic pressure (mechanical movement of the transducer) - External dynamic pressure (push pulses - can use ultrasound internally to cause stress)
357
What is required for strain quantification?
Autocorrelation of before/after A lines Autocorrelation of before/after frames Measurement of shear wave propagation
358
What are the reported drawbacks for static elastography?
1. User dependent - some people will push more than others. 2. Stress applied not reproducible 3. Indirect stiffness measurement 4. Difficult interpretation 5. Need direct access e.g. breast, prostate
359
What is transient elastography?
Electrodynamic transducer rhythmically pulses the ultrasound transducer on the surface of the skin - very heavily used in heptaology
360
Does transient elastography work?
- Can confirm cirrhosis - Hard to pick up different types of cirrhosis - Can't differentiate mild and significant fibrosis - There is a stretch in the axial direction
361
What is shear wave elastography? Diagram
- Deformation of tissue - Greater differentiation between normal and abnormal - Send out high MI pulse - Fire in succession at different depths - Causes rapid expansion of the tissue in all directions - Creates a lateral pressure - Shear waves travel slowly 3-4ms-1
362
Shear waves have a fast attenuation rate, what do they do to compensate?
- Multiple points in depth are emitted with a focused US beam - A shear wave front is created which corrects the fast attenuation - Emitted pulses are triggered at a speed greater than the speed of the shear wave propagation - Shear wave front creates a Mach cone
363
What are the 2 types of elastic wave?
Compressive | Shear
364
What is a compressive wave?
Compressive wave velocity is nearly uniform in soft tissue and is observed and sonic and ultrasonic frequencies c^2 = K/p ``` C = speed K = bulk modulus p = density ```
365
What is a shear wave?
``` Velocity varies strongly in the soft tissue - only observed at sonic frequencies (less than 1 kHz) C^2 = G/p C = speed G = shear modulus p = density ```
366
What is the advantage of supersonic shear imaging?
Much quicker Higher frame rate Combines shear and high frame rate and could cause a bit change Acquired data from large zones rather than multiple lines
367
What are the issues with shear elastography?
- Don't know frequency content of the propagating shear wave | - Do not know optimum frequency at which to probe the mechanical properties of the tissue
368
What 3 factors causes artefacts?
- artefacts that arise within the patient - Artefacts that arise within the equipment - Artefacts that are operator induced
369
What are the assumptions the imaging system makes about propagation of ultrasound?
- Beam axis is straight - Pulse only travels to targets that are on the beam axis and back to the transducer - The beam is thin (has negligible lateral width and slice thickness) - the speed to sound is constant - the attenuation in tissue is constant
370
What is the result of the assumptions not being necessarily true about US propagation?
- Echoes appear when structures are not really there - No echoes appearing where there is a structure - Size, shape and location of structures is inaccurate
371
Artefacts in US occur as structures that are:
- Not real - Missing - Improperly located - of incorrect brightness - Incorrect size - Incorrect shape
372
What are the in patient propagation artefacts?
- Acoustic shadowing - Acoustic enhancement - reverberation (comet tail) - Refraction - Edge shadow (refraction) - Mirror image - Speed of sound artefacts
373
When does acoustic shadowing occur?
When there is a high impedance mismatch between structures aligned along the axis of the beam, almost total reflection can occur. e.g. soft tissue and ribs - no echo is retrieved from the areas distal to ribs It will also occur when the beam passes through a structure that is highly attenuating e.g. lesions, cirrhosis. Most of the sound energy is lost through absorption and little detail can be seen distal
374
Draw a digram showing acoustic shadowing
Image
375
What methods are used to visualise tissue posterior to acoustic shadowing?
- By adapting the scan angle (best) - Compound imaging - In most instances, it is possible to interrogate areas posterior to the shadowing structure
376
When does acoustic enhancement occur?
When the sound beam passes through a structure that is of low attenuation. The echoes posteriorly appear brighter than surrounding tissue with the loss of information - Saturation of the image (turn down gain, change TGC)
377
Draw a diagram showing acoustic enhancement
Image
378
What is reverberation?
This occurs where the sound pulse bounces back and forth between 2 highly reflective surfaces So much energy is reflected from the boundary and it is reflected back off the transducer and back into the material. Machine assumes travel in straight line Get equally spaced false series reflectors.
379
Draw a diagram to show reverberation
Image
380
What is a comet tail artefact?
This is produced by a short pathway reverberation of the pulse between structures of high impedance mismatch. Pulse travels back and forth between the closely spaced reflectors producing a short time delay between each echo.
381
Draw an image depicting comet tail artefact
Image
382
What is the difference between comet tail artefact and reverberation?
Comet tail is a type of reverberation Comet tail occurs between 2 reflectors rather than between reflector and transducer
383
When does refraction occur?
Occurs at the boundary between 2 media where the speed of sound is different - When the beam hits the boundary at an angle, it is bent away from original course - Can lead to misleading appearances Doesn't happen very often
384
When can refraction occur?
Can look like twins due to refraction at abdominal muscles
385
Draw an image to show refraction
Image
386
Describe edge shadowing
- Curved interface at an oblique angle such as the edge of a cyst or soft mass within a solid tissue - Beam transmission is diverted (refracted) to a new direction - Shadow is caused by few echoes returning to the transducer from the original line of site
387
Draw a diagram showing edge shadowing (refraction)
Image
388
When does a mirror image artefact occur???
- Occurs due to specular reflection at a large smooth interface - High acoustic impedance mismatch - Reflected beam encounters a scattering target - Echoes from the target return via the same path to transducer - Mirror image seen behind the smooth reflector Strong reflector is meeting the beam at an angle - sound no longer travels in straight line (right angles) and the target is placed on straight line
389
Draw a diagram showing mirror image artefact
Image390
390
Where does mirror image artefact most commonly occur?
Diaphragm
391
What are speed of sound artefacts
Where the speed of sound in tissue between the target and transducer is higher than 1540ms-1 the target will appear closer to the probe than it really is. If it is slower it will appear further away
392
What are the consequences of speed of sound artefacts?
Measurement/size errors For most purposes displayed size changes +/- 5% not noticeable May need correction
393
Why do equipment related artefacts occur?
As a result of a number of false assumptions: - It assumes that any returning echo will have originated from the central axis of the beam - It assumes it has negligible lateral and slice thickness
394
What is beam width?
Width along scan plane Varies with distance from the probe Narrowest in the focal region Dependant on the type of focusing used
395
How can an equipment artefact arise from beam width?
2 reflectors placed side by side within the beam will be resolved only if the spacing between them is greater than the affective beam width
396
What is slice thickness?
Width of the beam at right angles to the scan plane
397
How can slice thickness cause an artefact?
Causes overlap of echo information from structures that lie outside the scan plane. Most noticeable in small liquid filled areas. They can have echoes from surrounding areas instead of being echo poor.
398
What is clutter?
Spurious signals that arise from echoes induced by ultrasound transmission outside the main beam Degrades the image Inhibits detection of weak echoes.
399
What is grating lobe artefact?
These are side lobes which can occur on any probe having regular spaced elements Weak replicas of the main beam at up to 90 degrees on each side of the beam Contribute spurious echoes to the image and effectively widen the beam in the scan plane. Reduces lateral and contrast resolution Reduced by use of harmonic imaging
400
How can you reduce grating lobe artefact?
Use harmonic imaging
401
Draw a diagram showing grating lobe artefact?
Image 402
402
Draw a diagram showing beam width artefact?
Image 403
403
What are the artefacts that are operator induced?
- Misuse of controls such as overall gain and TGC - Movement (FR not fast enough to show movement smoothly - Caliper inaccuracy (relies on correct calibration of pixel number to actual distance) - Transducer damage (loss of transmission by any of the crystals will lead to loss of image formation in that area. )
404
Describe a TGC artefact
- Occurs when applied compensation does not match the actual attenuation - May be due to operator error or due to large difference between actual and assumed constant values - Results in bright or echo poor banding across the image - 2 useful TGC artefacts are post cystic enhancement and acoustic shadowing
405
What is the result of having incorrect gain?
Overall gain too low (areas mimic fluid created where echo information is lost) If too high cystic areas will appear solid.
406
Vascular US: What can be determined in B Mode imaging?
Anatomical position of vessel Detail of vessel wall Lumen
407
What is B mode?
Brightness Mode Real time 2D imaging Single frames are acquired and played sequentially
408
Vascular US: What can be determined using colour encoded Doppler?
Map the course of the vessel Demonstrates vessel patency Identify stentotic segments Identify areas of flow turbulence
409
In colour Doppler, what do the colours represent?
Hue or colour saturation are used to indicate mean Doppler frequency or variance Colour is used to indicate flow
410
Vascular US: Main areas of application?
- Extracranial carotid arteries - AAA screening and surveillance - Lower limb arterial or venous disease - Graft surveillance and perioperative vein mapping - Haemodialysis fistulas - Upper limb disease
411
What are the common reasons for referral to examine carotid arteries?
Transient ischaemic attack (symptoms less than 24 hours) Loss of power or sensation of arms/legs/face Stroke (symptoms over 24 hours) US identifies the presence and extent of disease Ideal screening tool Treat: endarterctomy
412
Vascular US: Which transducer? Carotid arteries
High frequency - good resolution | 4-17MHz linear
413
What are the common reasons for referral to examine aorta?
- Palpable pulsatile abdominal mass - Surveillance of AAA - Screening for AAA - Suspicion of AAA (seen on radiograph) AAA= dilation over 3cm
414
Which transducer would you use to examine the aorta?
3-6MHz Curvilinear | Need penetration
415
How do you measure aorta?
Just inferior to renal arteries or if suspect AAA, at the widest point. Measure inner wall to inner wall. AP - must be at 90 degrees to long axis (no salami slice)
416
What are the common reasons for referral to examine lower limb arteries?
Intermittent claudication Absent pulse Screening of symptomatic patients Diagnosis, location and grading of disease
417
Which transducer to examine lower limb arteries?
4-17MHz linear | Use spectral Doppler
418
What are the common lower limb venous diseases?
DVT | Varicose veins
419
What is DVT? Reasons for referral?
Common Can result in fatal PE Painful swollen leg Chest pain
420
Which modality is best for DVT?
US now investigation of choice (not x-ray contrast venography) MRI useful for iliac veins where access is difficult (expensive) Need to assess the patency of deep veins, exclude the presence of a thrombus
421
Which transucer to examine DVT?
4-17MHz linear
422
What are the different types of venous grafts?
Synthetic | Native vein
423
What is the advantages of native vein grafts?
Best long term patency Mapping prior to surgery Avoids removal of unsuitable veins Reduces wound necrosis
424
Why is graft surveillance important?
30% of native will develop significant stenosis Reduces the risk of graft failure Intermittent claudication
425
Which transducer would you use to check vein grafting?
4-17MHz linear
426
What is a haemodialysis fistula? Which transducer to image?
AV connection that allows for high flow rates and can stand repeating needling for dialysis patients 4-17MHz linear
427
What are the common problems with haemodialysis fistulas?
Stenosis False aneurysms from repeated needling Clot formation
428
What are the objectives of 3D US?
- Acquire a set of 2D mages with positional information - Assemble the data into a 3D computer memory - Retrieve sleeted subset for display - Process and display selected data
429
What are the 3 scanning option for 3D US?
1. Conventional 2D transducer motor driven in predetermined format 2. Conventional transducer hand held with positional sensors allowing maximum operator freedom 3. 2D matric array
430
What are the different motor driven systems in 3D US?
Linear Sector format Anatomically constrained systems
431
Describe the linear motor driven systems for 3D
Linear movement Creates multiple slices in a 3D box Useless for patient scanning Simple Bulky (too large and inflexible) Impractical
432
Describe the sector format driven system for 3D
Motorised rocking sector Get a truncated pyramid with different slices Can rock with motor instead Reduces footprint Gives fan out Slice thickness is depth dependent
433
Describe anatomically constrained systems for 3d imaging
E.g. Intra vascular probe At each location it produces a slice at right angles to the probe Build an image from the inside out Successful in blood vessel As the region bend the machine is not aware and creates straight line
434
What are the features of a manually scanned system for 3d image acquisition?
Have position sensors attached to probe Operator has considerable freedom May not acquire optimum sections for reconstruction Machine determines images using operator movement There may be some gaps and some double scanned
435
What are the important features of position sensors in 3d imaging.
``` Operate using electromagnetic coupling Room conditions important Room needs to be fitted with detectors to work out where probe is Can't move machine out of the room Precision may be a problem ```
436
What are the disadvantages of using manually scanned systems for 3d image acquisition?
Can't move machine out of room Won't work if the couch is made of a conductive metal Location and precision can be problematic (need to know within 0.5mm in 3 axes and 2 angles) Operator may acquire suboptimal information
437
Describe matrix arrays for 3d image acquisition?
``` Allows for scanning in any plane Expensive and relatively uncommon Price will drop as increase manufacturers Can focus in 2 planes Can fire several at one time ```
438
What are the typical storage requirements for 3d imaging?
250k/slice To cover 10cm need approx 100 slices (if slice thickness 1mm) 100x250 = 25Mb
439
What are the 3 methods for reconstruction in 3d imaging?
Select an arbitrary section for display (most common) Use segmentation Use surface or volume rendering
440
What is multiplanar imaging analysis?
Have 2 screens 1 clinical image and one showing where you are located Can see scans in different planes
441
What is image segmentation?
Subdividing the image into component parts | Can be done manually or automatically
442
What is surface rendering?
Using pseudo lighting to highlight a surface | May need perspective transformation
443
What is volume rendering?
``` Not a true plane Visualisation of 3d structures as a 3d image Visualise surfaces (foetus) and internal structures (bones and vessels) ```
444
What does 4d imaging need?
High speed acquisition involving multiple simultaneous line processing
445
What are the advantages of ultrasound.
``` Readily available Cost effective Reliable, repeatable, reproducible Noninvasive Safe Rapid Tends to be first line investigation ```
446
What areas of the abdomen are commonly scanned?
Liver Biliary system Urinary system Spleen
447
Where is ultrasound imaging done in the patient pathway?
Prior to a and e - improve likelihood of poly traumatised patients POCUS - point of care us 2y e.g. Radiology department
448
Who is responsible for providing us?
``` Sonographer Radiologist Paramedics Emergency physician Trauma radiographer ```
449
What transducer is used in abdominal us?
3.5-6MHz curvilinear | Use 6+ in paediatrics or slim patients
450
What are the equipment settings that need to be considered?
``` TGC Overall gain Focus on ROI Consider MI and TI Compound imaging / harmonic imaging ```
451
What happens if you increase the number of focal zones?
More fine detail Increased lateral resolution More confident about diagnosis Time is a problem
452
What should be done in us of abdomen?
Survey all upper abdomens and surrounding areas Use 3 planes Additional views with sub costal and intercostal views Measure where relevant Outline: liver, ligaments, gall bladder, kidneys, vessels, porta hepatic, cbd, pancreas, spleen Include colour and pulse Doppler to evaluate vessels
453
What needs to be assessed in abdo us?
``` Size of organs and vessels Shape of organs and vessels Anatomical relationships Positions of organs and boundaries Texture ```
454
What are the reasons for referral for a liver and biliary system examination?
``` Ruq pain Epigastric pain Jaundice Abnormal LFTs Reflux ```
455
What is the normal appearance of the liver?
``` Homogeneous Midgrey echo texture Echogenic thin capsule surrounding Similar or slightly increase compared to kidney Ligaments are echogenic and linear ```
456
What are the common liver pathologies?
Diffuse disease e.g. Cirrhosis Masses Biliary dilation Portal hypertension
457
What are the advantages of us contrast?
``` Confined to intra vascular space (mr and ct is extra cellular) Easy to administer Immediate effect Well tolerated Good patient safety record Provides additional information Cost effective ```
458
What is the function of us contrast?
Characterises focal lesions Detects metastases Confirms normality Demonstrates vessel patency
459
What is the normal appearance of gall bladder?
Distended pear shaped sac Anechoic Echogenic thin wall Variable positions, size and shape
460
What are the common gall bladder pathologies?
Gall stones Polyps Wall thickening
461
Describe the appearance of gallstones
Echogenic Posterior acoustic shadowing Mobile Us very accurate at detecting
462
What are the features of a gall bladder polyp?
``` Common Not significant without gallstones Small intra luminal echogenic structure Fixed to wall No acoustic shadow Can be inflammatory, cholesterol or adenomyoma ```
463
What is the normal gall bladder wall thickness?
Less than 3mm when fasting
464
What are the common pancreatic pathologies.
``` Pancreatitis Dilation of pancreatic duct Pseudo cysts Masses Stones in pancreatic duct ```
465
How does pancreatitis appear?
``` Hypos choir Enlarged Pseudo cyst Pancreatic duct dilation Ascites ```
466
What do pancreatic pseudo cysts look like?
``` Echo free mass in lesser sac New has thin wall Old has thick Irregular borders Complex internal contents ```
467
What are the reasons for referral for a urinary system scan.
Loin pain Recurrent UTI Haematuria Abnormal urine rest
468
What are the common pathologies of the urinary system
``` Renal or bladder calculi Renal or bladder cancer Hydronephrosis Renal cysts Congential abnormalities ```
469
What are the reasons for referral for spleen scan
Luq pain Lymphoma Leukaemia Trauma
470
What are the common spleen pathologies.
Cysts Metastasis Lacerations Splenomegaly
471
What are the uses of Doppler in the abdomen.
Identify CBD from portal vein and hepatic artery Observing hyperaemia e.g. Cholecystitis Differentiating benign and malignant Portal vein assessment - patency, direction, thrombus, occlusion Splenic varies
472
What is a FAST ultrasound ?
Focused assessment with sonography for trauma Rules in free fluid Yes or no Primary assessment of blunt abdo trauma Very quick can be performed during resuscitation
473
WHat are the strengths of us?
``` Good for soft tissue Real time Blood flow information Well tolerated Inexpensive Portable Non ionising Control of invasive procedure ```
474
What are the weaknesses of us?
Difficult in patients with high bmi due to poor penetration Unable to penetrate bone Can't image lungs Limited views if gas overlying Operator dependent Need to label as no way to orientate after
475
What are the different types of echocardiography?
``` Transthoracic 4d Trans oesophageal Stress echo Contrast studies Dyssynchrony studies CRT optimisation Bubble studies ```
476
Outline transthoracic echocardiography
Assess cardiac structure and function Various views: parasternal (long axis and short axis), apical (2,4,5 chamber and long axis), sub costal, suprasternal and right sternal edge
477
What is the optimal position for echocardiography
Left lateral decubitus Raise left arm to open rib spaces Moves heart to front of chest Supine for sub costal and suprasternal views
478
Where is the probe placed for parasternal long axis
Left sternal edge 4th ic space
479
Describe parasternal long axis assessment
Use m mode for left ventricle to get internal dimensions e.g. Ejection fraction Colour flow M mode for aorta and left atrium
480
What should be assessed at parasternal short axis?
Left sternal edge rotate 90 degrees from long axis Colour flow Doppler for peak velocity over valves Assess left ventricle, mitral valves and papillary muscles
481
What should be assessed in apical 4 chamber view?
``` Image from apex of heart Identify wall segments Colour flow through mitral valve Mitral pulsed Doppler Mitral cw Doppler Tricuspid colour flow Doppler Tricuspid cw Doppler ```
482
What is sub costal echocardiography good for?
Identifying pericardial effusion | View IVC to see size and respiratory response
483
What should be viewed from suprasternal echocardiography
Aortic arch Good for aortic dissection Aortic Doppler Aortic cw Doppler
484
What probe is used for echocardiography
Phased array - need small footprint | 2-4MHz
485
What is the triple assessment of breast assessment.
Clinical examination Imaging Tissue sampling
486
What is the role of breast imaging
Screening program - a symptomatic 3yr mammogram | Symptomatic breast clinics - symptoms or post surgical surveillance
487
What breast pathology is most common in younger people?
Fibroadenoma (benign) Localised benign mass Abscesses in pregnancy
488
What are the common breast pathologies in the older woman
Cancer Increases with age Cysts
489
What are the guidelines for breast imaging
``` Mammography for over 40 Us for under 40 Standardised care Breast tissue over 40 is less glandular and less radio sensitive Mammogram is more sensitive than us ```
490
What is the role of us in breast imaging
Lesion characterisation. Assessment of axila prior to sentinel node biopsy Intervention Evaluation of areas of asymmetry on mammo Exclusion of masses Implants Male patients Follow up measurements during chemo When mammo contraindicated (pregnancy) Evaluation of microcalcifications picked up on mammo
491
Why is breast mammography not a screening tool?
``` Highly operator dependent Time consuming Small subtle changes can be missed Needs skilled use of equipment Microcalcifications hard to see ```
492
What probe is used in breast us.
7-15MHz linear array Dynamic range 60dB Can do compound imaging, harmonic imaging, extended Fov, Doppler or elastography
493
What are the malignant appearances breast Doppler
Chaotic irregular branching pattern Hypervascular Large vessels for lesion size
494
What are the benign appearances breast doppler
Organised vasculature Peripheral Aligned with septa Low number of vessels
495
What is the patient position for breast imaging
Supine with ipsilateral arm above head Better visualisation of lower quadrants Flatten breast to chest wall Minimise movement of breast
496
What are the different breast scan orientations
Longitudinal Radial Transverse Anti radial
497
What is gynaecomastia
Ductal proliferation Hyperplasia of glandular epithelium Increase stromal tissue
498
Define margins/borders and what comments can be made on them
``` Transition of echogenicity from mass and surrounding tissue Signifies change in acoustic appearance Well circumscribed Lobular end I'll defined Irregular Hyperechoic ```
499
Define echo texture, what are the options?
Comparison of echogenicity of surrounding tissues Hypo/hyper/an. - echoic Homo/Herero. - geneous
500
What are the features of a benign breast mass
``` Round Well defined An or Hyperechoic Homogeneous Posterior acoustic enhancement Compressible Mobile Wider than deep Surroundings unaltered ```
501
What are the malignant features of a breast mass
``` Irregular Ill defined Hypoechoic Heterogeneous Posterior acoustic shadowing Rigid Fixed or mobile Deeper than wide Altered surroundings ```
502
How are breast masses classified using us
``` 1 normal 2 benign 3 indeterminate - probably benign 4 suspicious of malignancy 5 highly suspicious of malignancy ``` Follow up 345
503
What procedures breast can be guided using us
Cyst aspiration | Hook wire placement