Unit 10: Diabetes

Question 1

Name the CLASSES of DIABETES MEDS

Answer 1

Biguinides
Thiazoladinediones
Sulfonylureas
Meglitinides
Alpha-Glucosidase Inhibitors
GLP-1 Receptor Agonists
DPP4 Inhibitors
Amylin Analogs
**glucagon

Question 2

Name the Insulin Sensitizers

Answer 2

Metformin

Thiazoladinediones (TZDs)

Question 3

Name the Insulin Secretogues

Answer 3

Sulfonylureas

Meglitinides

Question 4

Name the class that slows intestinal absorption of glucose

Answer 4

Alpha-Glucosidase Inhibitors

Question 5

Name the Incretin Memetics

Answer 5

GLP-1 Receptor Agonists

DPP4 Inhibitors

Question 6

Name the class that inhibits reabsorption of glucose in the kidneys

Answer 6

SGLT2 Inhibitors

Question 7

Name the Amylin Analogs

Answer 7

Symilin

Question 8

Name the diabetes drug classes that have multiple generations

Answer 8

Sulfonylureas

Question 9

Insulin: degludec

Answer 9

Tresiba

Question 10

Insulin: detemir

Answer 10

Levemir

Question 11

Insulin: glargine

Answer 11

Lantus

Question 12

Insulin: isophane

Answer 12

NPH

Question 13

Insulin: lispro

Answer 13

Humalog

Question 14

Insulin: aspart

Answer 14

Novolog

Question 15

Insulin: glulisine

Answer 15

Apidra

Question 16

Insulin NPL

Answer 16

neutral protamine lispro

Question 17

Insulin NPA

Answer 17

neutral protamine aspart

Question 18

Name 3 2nd Generation SULFONYLUREAS

Answer 18

glipizide (Glucotrol)
glimepiride (Amaryl)
glyburide (Diabeta, Micronase)

Question 19

Name a SULFONYLUREA on the BEERS list

Answer 19

glyburide

Question 20

Which SULFONYLUREA is preferred for the elderly and those with renal insufficiency?

Answer 20

glipizide (Glucotrol)

Question 21

What is the difference between SULFONYLUREAS and MEGLITINIDES?

Answer 21

sulfonylureas are short-acting

meglitinides are very rapid-acting and are used immediately before meals

Question 22

Name 2 MEGLITINIDES

Answer 22

repaglinide (Prandin)

neteglinide (Starlix)

Question 23

Name the BIGUANIDES

Answer 23

metformin (only drug in this class)

Question 24

Name 2 THIAZOLADINEDIONES

Answer 24

pioglitazone (Actos)

rosiglitazone (Avandia)

Question 25

What is the major black box warning for the TZDs?

Answer 25

can exacerbate heart failure CONTRAINDICATED in NYHA Class III-IV HF CAUTION with NYHA Class I-II HF

Question 26

Name 2 ALPHA GLUCOSIDASE INHIBITORS

Answer 26

acarbose (Precose) | miglitol (Diana, Diaset, Glyset, etc.)

Question 27

Which class of diabetes meds is very rarely used?

Answer 27

alpha glucosidase inhibitors

Question 28

Name 4 DPP-4 INHIBITORS

Answer 28

sitagliptin (Januvia) saxagliptin (Onglyza) linagliptin (Tradjenta) alogliptin (Nesina, Vipidia, Kazano)

Question 29

Name 4 GLP-1 RECEPTOR AGONISTS

Answer 29

exenatide (Byetta, Bydureon) liraglutide (Victoza) albiglutide (Tanzeum) dulaglutide (Trulicity)

Question 30

Name the injectable non-insulins that treat diabetes

Answer 30

``` GLP-1 RECEPTOR AGONISTS AMYLIN ANALOGS (Symlin) ```

Question 31

Name the dosing frequency for each of the GLP-1 RECEPTOR AGONISTS

Answer 31

``` exenatide (Byetta): pre-meal exenatide (Bydureon): weekly liraglutide (Victoza): daily albiglutide (Tanzeum): weekly dulaglutide (Trulicity): weekly ```

Question 32

Name 3 SGLT2 INHIBITORS

Answer 32

canagliflozon (Invokana) empagliflozin (Jardiance) dapagliflozin (Farxiga)

Question 33

Name the AMYLIN ANALOG

Answer 33

pramlintide (Symlin)