UNIT 1.2 PRENATAL HEMATOPOIESIS

Question 1

Hepatic period site

Answer 1

Fetal Liver

Question 2

Occurs intravascularly

Answer 2

Mesoblastic period

Question 3

when does BM
becomes the primary site

Answer 3

By the end of 24th weeks of gestation

Question 4

only initiate the production of red
blood cells if the bone marrow stops functioning.

Answer 4

extramedullary hematopoiesis

Question 5

two primary hematopoietic organs in leukopoiesis, especially in lymphopoiesis

Answer 5

• bone marrow
• thymus

Question 6

3 stages/periods of prenatal hematopoiesis:

Answer 6

1. Mesoblastic period
2. Hepatic period
3. Myeloid/Medullary period

Question 7

Hepatic period happens during

Answer 7

5th to 7th gestational week

Question 8

Myeloid/Medullary period site

Answer 8

medulla of BM

Question 9

the RBCs contain unique fetal hemoglobins :

Answer 9

○ Gower 1
○ Gower 2
○ Portland

Question 10

Sites of blood cell formation and circulation during MYELOID/MEDULLARY PERIOD

Answer 10

○ Epiphysis of the Long Bone
○ Flat Bones: Red Marrow

Question 11

in fetal development, contributory to the release of EPO are the ________ and _____

Answer 11

liver and kidneys

Question 12

hormone Necessary for the development in
production of red blood cells

Answer 12

Erythropoietin (EPO)

Question 13

hormone that Initiates white blood cells production

Answer 13

Granulocyte Colony Stimulating Factor
(G-CSF), Granulocyte Monocyte Colony
Stimulating Factor (GM-CSF)

Question 14

other name for mesoblatic period

Answer 14

Primitive Erythropoiesis

Question 15

Extramedullary organs:

Answer 15

• liver
• spleen
• thymus
• lymph nodes

Question 16

Occurs extravascularly

Answer 16

HEPATIC PERIOD

Question 17

Site of mesoblastic period

Answer 17

yolk sac of the embryo

Question 18

MYELOID/MEDULLARY PERIOD begins at

Answer 18

4th to 5th month of fetal development

Question 19

when does mesoblastic period happen

Answer 19

19th day after fertilization

Question 20

s the stimulus that would initiate the release of EPO in the kidneys targeting the bone marrow to produce RBCs

Answer 20

Hypoxia

Question 21

Megakaryopoeisis begins

Answer 21

Hepatic period

Question 22

MYELOID/MEDULLARY PERIOD have detectable leveles of:

Answer 22

• Erythropoietin (EPO)
• Granulocyte Colony Stimulating Factor (G-CSF)
• Granulocyte Monocyte Colony
  Stimulating Factor (GM-CSF)

Question 23

HEPATIC PERIOD Hemoglobin:

Answer 23

○ Fetal hemoglobin
○ HbA
○ HbA2

Question 24

n a newborn, all the bone marrow is ________, and all of it is
involved in red blood cell production

Answer 24

red marrow

Question 25

Development of primitive erythroblasts

Answer 25

Mesoblastic period

Question 26

Beginning of definitive hematopoiesis

Answer 26

HEPATIC PERIOD

Question 27

hormone that Targets the cells of the bone marrow

Answer 27

Erythropoietin (EPO)