UNIT 1.2 STEM CELLs Flashcards
HEMATOPOIETIC STEM CELLS are capable of
○ Self-renewal,
○ Pluripotent
○ Give rise to differentiated progeny
megakaryocyte becomes
platelets
T lymphoblast becomes
T cell
B lymphoblast becomes
B cell
Respond best to multiple cytokines
PROGENITOR CELLS
much
more mature than progenitor cells
PROGENITOR CELLS
all blood cells are derived
from a single progenitor stem cell
MONOPHYLETIC THEORY
pre-T becomes
T lymphoblast
Progeny increasingly acquire specific differentiation markers and function
PROGENITOR CELLS
megakaryoblast becomes
megakaryocyte
pronormoblast becomes
erythrocyte
Are multipotent
PROGENITOR CELLS
megakaryocyte-erythrocyte progenitor becomes
- pronormoblast
- megakaryoblast
each of the blood cell lineages
is derived from its own unique stem cell
POLYPHYLETIC THEORY
pre-B becomes
B lymphoblast
myeloblast becomes
- neutrophil
- eosinophil
- basophil
Blast cells committed to unilinear differentiation
PRECURSOR CELLS
Do not self-renew or have only an extremely limited
capacity
PROGENITOR CELLS
Common myeloid progenitor becomes
- granulocyte-monocyte progenitor
- eosinophil-basophil progenitor
- megakaryocyte-erythrocyte progenitor
- mast cells
granulocyte-monocyte progenitor becomes
- myeloblast
- monoblast
Hematopoietic stem cells become
- Common myeloid progenitor
- common lympoid progenitor
HEMATOPOIETIC STEM CELLS Fates:
○ Self-renewal
○ Differentiation
○ Apoptosis
still replicate until near terminal differentiation
PROGENITOR CELLS
eosinophil-basophil progenitor becomes
myeloblast
