UNIT 2 Flashcards
(67 cards)
- interacts with a drug
- initiates the chain of events
Receptor
central focus of investigation of drug effects and their mechanisms of action
Receptor
The receptor concept, extended to what areas
endocrinology, immunology, and molecular biology
Important practical consequences of receptor concept
- development of drugs
- therapeutic decisions in clinical practice.
Receptors largely determine the ___ relations between ___ of drug and ___
Quantitative; dose or concentration; pharmacologic effects
T/F
total number of receptors may limit the maximal effect a drug may produce.
Th
T/F
Receptors are responsible for selectivity of drug action.
T; receptors select the drug action
T/F
The affinity of the drug to its receptor depends on the molecular size, shape, and electrical charge of the drug
T
T/F
Change in the chemical structure of a drug will also change its affinity, and toxic/therapeutic effect
T
T/F
Receptors mediate the actions of pharmacologic agonists and antagonists.
T
- regulate the function of receptor macromolecules
-they activate the receptor to signal as a DIRECT RESULT of binding to it.
Agonists
ie. some drugs and natural ligands (hormones, neurotransmitters)
T/F
Some agonists activate a single kind of receptor to produce all their biologic functions
T
T/F
other agonists selectively promote one receptor function more than another.
T
- bind to receptors but do not activate generation of a signal
- they interfere with the ability of an agonist to activate the receptor.
Antagonists = pakielamero
T/F
Antagonists are useless
F; their blocking action is purposeful
- bind to a different site on the receptor and can produce useful and quite different clinical effects
Allosteric modulators
T/F
Most receptors for clinically relevant drugs, and almost all of the receptors are proteins.
T
used to identify or purify receptor proteins from tissue extracts
Drug binding; was traditionally used
T/F
receptors were discovered after the drugs that bind to them
T
natural ligands are presently unknown
Orphan receptors
- best-characterized drug receptors
- mediate the actions of endogenous chemical signals (hormones, neurotransmitters, autocoids)
Regulatory proteins
mediates the effects of many of the most useful therapeutic agents.
Regulatory receptors