Unit 3 Material - NEW only! Flashcards
(69 cards)
A lyssavirus that has linear, single stranded RNA and is negative sense:
rabies
Zoonotic and affects the CNS:
Rabies
What are the two serotypes of vesicular stomatitis virus?
Indiana, NJ
The majority of Rhabdoviridae occur in:
insects
What number of proteins does rabies code for?
The genome is 12 kb and codes for 5 proteins
Sylvatic means:
of the woods
Street rabies affects:
dogs and cats (domestic)
Why is there no street rabies in the US?
vaccines
How is rabies inoculated?
by the bite of an infected animals
Where does attachment, penetration, and uncoating occur?
locally in the myocytes
Where does transmission of rabies to a nerve cell occur?
at the neuromuscular junction and sensory endings of the PNS
Where does viral establishment of rabies occur?
in the PNS
Where does rabies localize once it enters the spinal cord and brain?
soma of the neurons
Which sections of the brain are the most heavily affected by rabies?
hippocampus, brain stem, and purkinje cells of the cerebellum
Where is the rabies virus released?
ONLY at the nerve endings
How does rabies cause death?
neural respiratory and cardiac arrest
What are the three routes to the CNS rabies takes?
- hematogenous
- neural pathways
- olfactory
Which rabies route to the CNS: “via viremia that can infect endothelium, and leukocytes, passive transport through permeable areas can occur”
hematogenous
Which rabies route to the CNS: “axons, Schwann cells, perineural lymphatics, and endoneural spaces”
neural
Which rabies route to the CNS: “cranial nerve penetrates the cribiform plate”
olfactory
IC inclusions in neuronal soma present in hangla of hippocampus, purkinje cells of cerebellum, and medullary ganglia:
negri bodies
Where are negri bodies located?
cells of the brain (purkinje cells?)
Small, round, structured viruses that exhibit icosahedral symmetry:
Calici virus
What kind of outer covering is on a Calici virus?
capsid, NOT an envelope
