Urolithiasis in small animals Flashcards

(55 cards)

1
Q

Size - uroliths

A

macroscopic (crystals = microscopic)

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2
Q

T/F: you can have crystals without uroliths and uroliths without crystals

A

True

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3
Q

Are crystals always representative of urolith type?

A

May be but not always

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4
Q

How are uroliths described?

A
  • mineral component

- location

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5
Q

How are uroliths formed?

A
  • crystlas form when urine is supersaturated

- concentration of solute required to start the process (nucleation) generally higher than that needed for growth

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6
Q

PE - nephroliths and ureteroliths

A
  • often normal

- hydronephrsis/ irregular kidneys

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7
Q

CS - cystoliths

A
  • dysuria
  • pollakiuria
  • haematuria
  • inappropriate urination
  • generally not palpation
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8
Q

CS - urethroliths

A
  • abdominal discomfort
  • poor/no urine stream
  • licking genitals
  • obstruction and post-renal azotaemia
  • enlarged painful bladder, urethroliths may be palpable per rectum or at base of penis
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9
Q

Dx - urolithiasis

A
  • compatible hx and CS
  • plain radiographs (radiodence uroliths if sufficienctly large)
  • contrast radiograph (excretory urogram for nephroliths, reteroliths, double contrast - bladder, retrograde - urethra)
  • ultrasound
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10
Q

How can you predict urolith type?

A
  • signalment
  • radiopaque/lucent
  • urine pH
  • hx of a particular stone type
  • UTI associated with struvite
  • disease associations
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11
Q

Urinalysis - analysis

A
  • qualitative analysis not reliable

- quantitative analysis required (reputable lab) = xray diffraction (detailed analysis of mineral composition)

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12
Q

General tx considerations - renal and ureteral stone

A
  • sx removal (traumatic)
  • urinary bypass
  • lithotripsy (non-UK)
  • dietary dissolution (must be non-obstructed, often CaCO3 which isn’t amenable to dissolution)
  • benign neglect
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13
Q

General tx considerations - bladder stone

A
  • medical dissolution
  • voiding urohydropulsion (VUH)
  • sx (cystotomy)
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14
Q

General tx considerations - urethral stone

A
  • retrograde flush into bladder

- sx (urethrotomy, urethrostomy)

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15
Q

Indications - medical management

A
  • prior to sx if appropriate
  • no obstruction
  • no CI to dietary therapy
  • urolith composition amenable to dissolution
  • struvite, cystine an durate
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16
Q

Principles - medical management of uroliths

A
  • decreased concentration in urine by increasing water intake
  • decrease quantity of calculogenic cyrstalloids by diet r drugs
  • increase solubility of slats by changing urine pH by diet
  • tx predisposing cause
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17
Q

Outline urohydropulsion

A
  • fill bladder with saline
  • position so urethra vertical
  • agitate
  • allow stones to settle
  • initiate voiding
  • conitnue pressure to keep brisk urine flow
  • 3 days ABs
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18
Q

Other names - struvite crystals

A
  • magnesium ammonium phosphate

- triple phosphate

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19
Q

Outline struvite crystals

A
  • many breeds
  • most dogs have concurrent UTI
  • most female
  • urease producing bacteria (Staph, Proteus)
  • cleave urea –> ammonium + bicarbonate
  • alkaline urine pH
  • sterile in cats
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20
Q

Struvite - tx

A
  • treat UTI for 3-4 weeks after radiographic resolution
  • reduce urinary Mg, ammonium, phosphate
  • maintain pH
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21
Q

Struvite prevention

A
  • hill’s and royal canin preventative diets
  • long term preventative tx not recommended for dogs unless sterile stones
  • monitor for UTI recurrence
  • diets designed to prevent struvite recurrence may lead to calcium oxalate stone formation
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22
Q

Signalment - calcium oxalate

A
  • increased incidence, esp cats (inappropriate acidifying diet to prevent struvite but promotes oxalate)
  • terriers, poodles, schnauzers, burmese, himalayan, persian
  • older animals
  • upper urinary tract
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23
Q

Calcium oxalate - tx

A
  • sx
  • urohydropulsion
  • medical dissolution not possible
  • ignore
  • 60% recurrence within 3 years
24
Q

Prevention - calcium oxalate

A
  • increase water intake (least controversial idea)
  • sodium supplementation? (salt –> drinks more. induces diuresis)
  • neutralising urine pH won’t have a big effect (calcium oxalate solubility not pH dependent, acidiying diets promote calcium excretion)
25
What is laser lithotripsy?
- guided by cystoscopy - fragments removed by VUH - BUT energy absorbed by water (effects only within 1-2mm fibre tip)
26
Outline ammonium urate stones
- 8% canine stones - DALMATIONS: reduced conversion of uric acid to allantoin, defective transport of uric acid into hepatocytes andout of urine - Hepatic dysfunction: PSS, increased excretion of ammonia and urea. - bulldogs and others
27
Ammonium urate - tx
- tx underlying liver disease and PSS - otherwise dissolution - tx any UTI - reduce purine, neutral to alkalinepH (Hills u/d) - allopurinol (competitively inhibits xanthine oxidase, reducing uric acid this can result in xanthine stones if protein not restricted)
28
Describe cystine stones
- 3% canine stones (breeds) - renal tubular defect resulting in excess urine cystine which is poorly soluble - typically middle aged, despite being a congenital problem - radiolucent - medical dissolution effective but v expensive - cystine excretion decreased by castration
29
Describe calcium phosphate stones
- associated with primary hyperPTH - also mixed urolith - inerlaistion of blood clot
30
Describe calcium carbonate stones
- commonest in horses and rabbits | - high {Ca2+] in ruine
31
Describe silica stones
- GSDs predisposed - rare - associated with poor diets
32
Sx management of urolithiasis - indications
- UT obstruction - unknown or unpredictable urolith composition - failed medical tx - presence of other urinary tract abnormalities - immature dogs (d/t specific dietary requirements) - owner preference - cost
33
Sx options
- open viscus and remove calculi (nephrotomy, pyelotomy, ureterotomy, cystotomy, urethrotomy) - provide urine diversion (create an artificial opening, usually permanent)
34
General sx considerations
- stabilise hyperkalaemic and severely azotaemic animals pre-sx - ensure # and location of calculi are known immediately before sx - place indwelling urinary catheter (with extension set) and empty bladder - check all calculi / fragments of calculi are removed at end of sx - submit calculi for quantitative analysis
35
Method - cystotomy
- place urinary catheter connected to an extension set prior to sx - caudal midline ventral celiotomy, care entering peritoneal lcavity - locate bladder and empty if necessary, place stay suture - prolene, in apex - pack of abdominal cavity - ventral midline cystotomy and use further stay sutures to aid manipulaiton - remove obvious calculi (forceps) - save for quantitative analysis and culture - flush urethra with sterile saline - non-sterile assistant to do until ALL calculi removed - close bladder using syntehtic absorbable material e.g. poliglecaprone = monocryl, single or double layer, continuous or interrupted, appositional or inverting, try and avoid placing stay suture in bladder lumen
36
What are end of cystotomy considerations?
- are all calculi removed - consider xray post-op - generally indwelling catheter not used - usual to keep on IVFT for 12-24 hours - need to be allowed to urinate frequently - analgesia - medical management (dependent on calculus)
37
Risks/complications - cystotomy
- not removing all calculi -> CS recur - dehiscence of bladder --> uroperitoneum - blood clot --> outflow obstruction - CS: cystitis
38
Radiographic density of calcium oxalate monohydrate (COM)/ dihydrate (COD)
moderately to markedly radiopaue
39
Surface characteristics - COM/COD
sharp projections, mulberry shaped or smooth round uroliths | - COD may be jackstone shaped
40
Urine pH - COM/COD
acidic to neutral
41
Crystalluria with COM/COD
- COM crystals (dumbbell or picket fence shapes) | - COD (square envelopes)
42
UTI with COM/COD
None or secondary UTI with common uropathogens
43
Breeds - COM/COD
- miniature schnauzer - lhasa apso - YT - bichon firse - pomeranian - shih tzu - birmese, himalayan, persian
44
Uroliths of COM/COD
often multiple small uroliths in bladder. multiple nephrolights is present. - males > females (dogs and cats)
45
Radiographic density - struvite
mod to markedly radiopaque | - larger uroliths more radiopaque
46
Surface characteristics - struvite
SINGLE: smooth or speculated, may assume shape of bladder MULTIPLE: smooth surfaces where uroliths contact each other, often pyramidial
47
Urine pH - struvite
alkaline
48
Crystalluria with struvite
struvite or 'triple phosphate' crystals (coffin lid appearance)
49
UTI with struvite
urease producing organisms (staph,proteus, mycoplasma). | - sterile struvite uroliths in cocker spaniels and cats
50
Breeds - struvite
- miniature schnauzer - shih tzu - bichon firse - miniature poodle - cocker spaniel - lhasa apso
51
Uroliths > what size are likely to be struvite?
>1cm
52
Describe urate/xanthine stoes
- radiolucent to faintly radioopaque - multiple smooth uroliths - acidic urine - ammonium urate crystals (yellow-brown 'thornapple or spherical') or amoprhous urate crystals - no UTI or secondary UTI with common uropathogens. Rarely urease producing organisms - Dalmation, english bulldog,miniature schnauzer, shih tzu, YT - PSS or other liver dysfunction - yellow-green urolith colour, - DOGS: Males> females - CATS: equal b/w sexes
53
Describe cystine stones
- radiolucent to moderately radioopaque - multiple smooth round uroliths in bladde/urethra - nephroliths staghorn shape - acidic urine - cystine crystalluria always abnormal - no UTI or seconday UTI with common uropathogens - mastiff, australian cattle dog, english bulldog, SBT, newfoundland, dachshund - positive urine-cyanide nitroprusside test - metabolic screening of urine available - DOGS: males>>>>females
54
Describe calcium phosphate crystals
- moderately to markedly radioopaque - SURFACE: hydroxyapatite (multiple small uroliths with variable shape) or brushite (multiple smooth round or pyramidal uroliths) - alkaline to neutralurine pH for hydroxyapaptite, acidic for brushite - crystalluria: amorphous phosphates or calcium phosphate crystals (thin prisms) - no UTI or secondary UTI with common uropathogens - YT, miniature schnauzer, bichon friese, shih tzu, springer spaniel, pomeranian, miniature poodle, cocker spaniel - hypercalcaemia predisposes this
55
Describe silica crystals
- moderately radioopaque - classic jackstone appearance - acidic to neutral urine pH - no crystalluria - no UTI or secondary UTI with common uropathogens - GSD, OESH, labrador retriever - males >> females