Useful

Question 1

Drugs associated with cholestasis

Answer 1

The following drugs tend to cause cholestasis (+/- hepatitis):
oral contraceptive pill
antibiotics: flucloxacillin, co-amoxiclav, erythromycin*
anabolic steroids, testosterones
phenothiazines: chlorpromazine, prochlorperazine
sulphonylureas
fibrates
rare reported causes: nifedipine

Question 2

Drugs associated with hepatocellular picture

Answer 2

The following drugs tend to cause a hepatocellular picture:
paracetamol
sodium valproate, phenytoin
MAOIs
halothane
anti-tuberculosis: isoniazid, rifampicin, pyrazinamide
statins
alcohol
amiodarone
methyldopa
nitrofurantoin

Question 3

Drugs associated with cirrhosis

Answer 3

Liver cirrhosis
methotrexate
methyldopa
amiodarone