Uveitis

Question 1

What is Uvea and Uveitis ?

Answer 1

Uveitis is inflammation of the uveal tract, which includes:

Iris

Ciliary body

Choroid

Question 2

Anatomical Subtypes of Uveitis ?

Answer 2

Question 3

How Etiological classification of Uveitis ?

Answer 3

1.Infectious
2.Non-Infectious
3.Masquerade

Question 4

Example of Infectious Uveitis ?

Answer 4

A. Infectious

Bacterial: TB, syphilis, Lyme

Viral: HSV, VZV, CMV

Parasitic: Toxoplasma gondii

Fungal: Candida, Aspergillus (especially endogenous endophthalmitis)

Question 5

Example of Non-Infectious Uveitis ?

Answer 5

Autoimmune-associated:

-HLA-B27 (ankylosing spondylitis, Reiter’s, etc.)

-JIA

-Sarcoidosis

-Behçet’s disease

-VKH, sympathetic ophthalmia

Question 6

Example of Masquerade ?

Answer 6

-Intraocular lymphoma

-Retinoblastoma

-Chronic post-surgical inflammation

Question 7

Describe Clinical Presentation by anatomical subtype ?

Answer 7

Question 8

Diagnostic Work up ?

Answer 8

AutoImmune Related Uveitis
> CBC ESR CRP
> HLAB27 , SY workup
> ANA RF

Question 9

Treatment idea ?

Answer 9

Non-infectious uveitis
-Corticosteroids:

*Topical (prednisolone acetate 1%)

*Periocular/intravitreal (triamcinolone)

*Systemic (prednisone 1 mg/kg/day)

-Immunomodulatory therapy:

*Methotrexate, mycophenolate, azathioprine, cyclosporine

Question 10

Infectious Uveitis treatment ?

Answer 10

Antimicrobials according to etiology

Steroids only after antimicrobial coverage

Question 11

What cause Anterior Uveitis ?

Answer 11

HSV VZV CMV