Uworld Mix 10/9-9 Flashcards

1
Q

35 IVDU has right sided wekaness that started 2 hours ago. Has had night sweats and malaise for the last 7 days. 102F, HTN., Tachy. Neuro exam shows 3/5 strength on right side. Theres small mobile vegetation of the aortic valve and mild aortic regurgitation. BCx done, IV antibiotics given. WHICH IS THE NEXT STEP?

  • Aortic valve surgery
  • Continue Current care with observation
  • Antiplatelet therapy
  • Start IV heparin
  • Start Oral Warfarin
A

Continue care with observation

patient has a cerebral infarct from bacterial endocarditis with an acute stroke==TIA.

All you can do is give Antibiotics

ASA should have been used early and for atherosclerosis.
Heparin IS CONTRAINDICATED -would cause intracranial hemorrhage.
Would use warfarin b/c this is far cardiembolix stroke due to AFIB. Not in this patient.

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2
Q

30 year old school teacher - 3 day hisotry of fever, chills, and sore throat. He denish cough, chest pain, or difficulty breathing. He has enlarged tender cervical lymph nodes on the left, and uvula is deviated to the right. What is the most appropriate tx?

A

Needle peritonsillar aspiration, THEN do antibiotics.

Because the abscess is obviously there, its more complicated than a throat swab and just abx is not enough.

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3
Q

What two modalities of diagnosis are used to diagnose a stone in the urerters, and which is most appropriate to do first.

A

CT and Ultrasound. But US is done first.

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4
Q

Patient has back pain that is releived with leaning forward, but hurts when leaning back. Pain radiates to the buttocks with no urinary issues. There is no pain when he lays down at night. His back pain is more related to posture. What is it

A

Lumbar Spinal stenosis, aka Osteoarthiritis of the spine. - Neurogenic Claudication

Lumnbar extension would narrow the spinal canal.

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5
Q

Young person with back pain that worses with rest and improve with activity.

A

Ankylosing Sponyliitis (seronegative)

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6
Q

Patient has back pain that is relieved with leaning forward, hurts with leaning back, depends on if he’s exerting himself. There is decreased pulses, cool extremties, and diagnosed with ankle brachial index

A

Vascular claudiaction - aorteliac atherosclerosis

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7
Q

What are the wells criteria to deduce the clinical probability of PE

A

+3 - signs of DVT or alternate diagnosis less likely than PE

+1.5 - Previous PE or DVT, HR >100, Recent immobilization.

+1 - Hemoptysis, Cancer

Need >4.

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8
Q

31 female has SOB and anxiety. She was on a recent plane ride. Non smoker. Uses condoms with sex. Has only a hx of anxiety and sleep probelms, and FH of colon cancer. No edema, no skin rashes.

Ph 7.43, CO2 35, PaO2 90.

D Dimer Normal as is Xray.

What is her likelyhood of PE, and what do you do next?

A

Not likely.

Reassurance

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9
Q

What do you do when PE is unlikely

A

PE unlikely–> D-dimer.

If >500 Do Ct Angio.

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10
Q

Patient has Giant Cell artirits that is treated. 6 months later, she has difficulter climbing up stairs and getting up from a chair. she has decreased strenght in the proximal lower extremities.
Normal ESR and CK

A

Drug induced myopathy due to steroids.

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11
Q

Muslce pain and stiffness in the shoulder and pelvic girdle.
Tenderness with decerased range of motion at shoulder, neck and hp
RESPONDS to steroids
ESR increased

A

Polymyalgia Rheumatica

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12
Q

1 hour old premature girl is born, had preterm premature rupture of membranes. Born via csection. Thers severe respiratory distress. CXR shows increased lung volumes and fluid in the interlobar fissures. What is the etiology?

A

Delayed resorption and clearance of alveolar fluid - This is Transient Tachypnea of the Newborn

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13
Q

Findings of Transient Tachypnea of the newborn

A

Tachypnea, Increased work of breathing, CLEAR breath sounds, Chest X ray shows hyperinflation, fluid in fissures.

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14
Q

Management f Transient Tachypnea of the Newborn

A

Supportive care, resolves in 1-3 days.

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15
Q

What are risk factors of TTN

A

C-section, preamture

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16
Q

Patient has a 20 pack smoking history, and a plamber for the past 30. CXR shows atelectasis, bilateral pleural plaques over diaphragm. Theres a round 6 cm cavitary mass in the right lower lung field. What is most likely found on biopsy?

Bronchogenic cancer or Mesothelioma?

A

Bronchogenic Cancer

Remember that cancer is MORE common result of asbestos in smokers than mesothelioma.

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17
Q

What are three PULMONARY and 2 systemic causes of hemopthysis

A

Bronchitis, Bronchiectasis, and Lung Cancer, Granulomatosis with Polyangiitis, Goodpasture syndrome

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18
Q

Describe Bronchiectasis

A

IRREVERSIBLE dilation and destruction of bronchi, resulting in chronic cough and inadequate mucus clearance. Have a hx of recurrent respiratory tract infections

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19
Q

72 year old man passes out while getting out of bed. He had recent watery diarrhea for the past 2-3 days. BP studies show orthostatic hypotension. Asucultation shows clear lung fields. ECG normal. What is the MOST SENSITIVE indicator of the condition

A

Decreased Urine NA.

Hypovolumia from diarrhea –> increased aldosterone production –>causing Na resorption and K wasting.

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20
Q

PFts of Interstitial lung disease

A

normal to inc Fev1/FvC ratio, DECREASED DLCO, dec TLC, dec RV

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21
Q

Etiologies of exudative thoracentesis

A

Empyema - see neutrophils in fluid. This is bacterial infection.

Chylothorax - Milky white fluid, increased triglycerides. from DISRUPTION OF THORACIC DUCT

Malignancy

TB

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22
Q

What is are the PFTs for COPD or chronic bronchitis

A

FEV1/FVc <70% predicted, and a NORMAL DLCO.

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23
Q

What would have an obstructive pattern and LOW DLCo

A

Emphysema.

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24
Q

What would have an Obstructive pattern and INCEASED DLCO

A

Asthma

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25
Q

What would have restrictive pattern and LOW DLCO

A

Interstitial lung disease, sarcoidosis, asbestosis, heart failure

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26
Q

what are the features of COMPLICATED effusion from pneumonia

A

Bacterial invasion - ph<7.2, Glucose <60, WBC >50k

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27
Q
What would you change on a ventilator in a patient who has respiratory failure, bilateral opacities, and ABG of 
pH 7.45
PaO2 54
PaCO2 30
HCO3 - 21
A

INcrease in PEEP.

This both oxygenates AND stops respiratory collapse in ARDS

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28
Q

What would the Arterial O2/FiO2 ratio in a patient with ARDS and an xray showing diffuse interstitial infiltrates. ?

A

Decreased.

the PaO2 decreases, leading to a BIGGER FIO2 requirement. <300.

More decreased, more severe.

29
Q

Decribe the effect of ARDS on lung compliance

A

leakage of fluid inot the alveoli, alveolar collapse due to loss of surfactant and increased elastic recoild of edematous lungs.

30
Q

What is consistent with “alveolar spaces filled with fibroblasts”

A

interstitial lung disease. NOT systemic sclerosis.

31
Q

When do you use diuretics instead of thoracentesis when you see fluid on chest x ray

A

when you know the patient has heart failure.

Thoracentesis is done first to see etiology otherwise.

32
Q

What is the ONLY condition wher you heard increased breth sounds.

A

Lung consolidation - lobar pneumonia.

33
Q

What kind of back pain is when the patient is young, has pain thats worse with rest, better when leaning forward

A

Ankylosing spondylitis

34
Q

5 year old girl has malodorous vaginal discharge and a small amount of bleeding for about a week. She takes frequent baths. She has no fever, abdominal pain, or dysuria, The discharge is white, inside the vaginal introits. What is the next step?

A

Irrigate with warmed fluid after local anesthetic application.

35
Q

difference between Anti-topoisomerase I antibodies and Anti-Smooth Muscle

A

Anti smooth muscle - auto-immune hepatitis

Anti-toposimerase I - Systemic Sclerosis

36
Q

Anti-centromere antibodies

A

Systemic Sclerosis

37
Q

Difference in presentation between CJD and FTD

A

FTD has teh onset around 50, personality changes are more prominent than cognitive. No change on EEG

CJD - shapr triphasic synchronous discharges on eeg.

38
Q

What kind of abortion - Vaginal bleeding, Dilated cervical os, products of conception seen or felt at or above the os.

A

Inevitable

39
Q

So, 7 week pregnant lady had really bad bleeding and abdominal pain. There are blood clots in the vaginal vault and active bleeding from a dilated cervix. Bimanoua exam shows a 6 week size uterus. What kind of abortion is it.

A

Inevitable

40
Q

Abortion - No Vaginal Bleeding, Closed Os, No fetal cardiace activity or empty sac

A

Missed abortion.

41
Q

Abortino - Vaginal bleeding, closed os, fetal cardiac activity

A

Threatened

42
Q

Woman has right hip pain for the past 4 weeks, increased with weight bearing. Theres no warmth, erythemia, or other joint pain. She dx with SLE 7 years ago. She is afebrile, and vital signs are normal. There is no tenderness over ANY joints. ROM is normal.X ray is normal. What is the next step

A

MRI of the hip they have avascular necrosis

43
Q

Woman has right hip pain for the past 4 weeks, increased with weight bearing. Theres no warmth, erythemia, or other joint pain. She dx with SLE 7 years ago. She is afebrile, and vital signs are normal. There is no tenderness over ANY joints. ROM is normal.X ray is normal. Why do you NOT aspirate the joint?

A

You would do Arthrocentesis if they have warmth, or inflammatory symptoms, or decreased range of motion.

44
Q

What would be the lab findings in avascular necrosis

A

Normal white blood cell count, normal ESR and CRP.

45
Q

What steps do you take if a 5 year old patient has a varicella infection, and had received 1 varicella immunization shot, and otherwise UTD with vacs.

A

Give the Varicella vaccine.

46
Q

What when do you give the Varicella Zoster Immunoglobulin?

A

When the kid DOESNT have 2 doses of the vaccine, and is IMMUNOCOMPROMISED

47
Q

What is the most common heart defect in Edwards sydrome (trisomy 18) when the murmur at the left lower sternal border

A

VSD

48
Q

What are other heart defects are associated with edwards, and should consider if the mumur correlates

A

ASD and PDA

49
Q

36 man with 6 month history of headache, decreased libido. He has a hx of t2dm and bipoalr disorder, treated with metformin and risperidone. He has decreased testicular volume. Labs:

Lh 0.5 (low)
Test 100 (below normal)
Tsh 0.05 (low)
T4 - 0.45 (low)
Prolactin 35 HIGH

Which of the following is the most likely diagnosis

A

Pituitary adenoma -

Patient has both central hypothyroidism (low TSH and low T4) and central hypogonadism (low LH and low testosterone)

This means a NONfunctioning pituitary adenoma. causes a mass effect on local tissues, so most of the other pituitary hormones wil be DECREASED by compression.

50
Q

Man has had ascending paralysis tht began 18 hours earlier. The parasthesis is more common in the left leg. No fever. He recently came back from a hiking trip to Colorado. He has absent DTR, no motor activity. Theres no abnormalities are noted on CSF examination. WHat is the next step?

A

Meticulous search for a tick. In tick borne paralysis:

No Fever
Sensation is intact
CSF normal

51
Q

If a patient has signs of spinal compression, what do you do

A

Steroids and then MRI to confirm.

52
Q

61 male has nocturnal urinary frequency, occasional dribbling, and a weak urinary stream for the past 3 months. Hes had T2DM for the past 16 years. BP is 160/100, and pulse is 70. He has a left carotid bruit and trace bilateral ankle edema. UA shows 3+ protein, and no blood. Cr is 2.1 What is the cause of the CKD?

A

Microangiopathy - he most likely has diabetic glomerulosclerosis - causing diabetic nephropathy.

Damage glomerulos lead to nephropathy– may lead to albuminuria

53
Q

What are the steps of kidny damage with diabetes

A

Glomerular hypertrophy 0-5 years, Mesangial expansion, membran thicking, arteriolar hyalinosis, then mesangial nodules.

54
Q

45 year old man has dyspnea, poor appetitis, and weight gain over 2 weeks, He has worsening shortness of breath with exertion. He cant even open his eyes due to the facial edema. BP is 200/120, and puls is 100. He has anasarca with distended JVP while sitting upright. Theres crackles in the lungs.

UA shows 1+ protein, no nitrite, trace leukocyte esterase, >50 rbcs, rbc casts, and occasional neutrophils.

Why does he have edema?

A

Primary GLomerular damage.

He has acute nephritic syndrome due to fluid overload. The extreme proteinurie lead to hypoalbumiuria, leading to the edema.

55
Q

What are causes of acute peripheral edema

A

Increased Capillary Hydrostatic Pressure
Decreased oncotic pressure
Increased capullary permeability
Lymphatic obstruction.

56
Q

What is a “Small Vessel Lipohyalinosis”

A

Lacunar Infarct

57
Q

What are the features of a lacunar stroke?

A

Abscence of cortical signs - aphasia, agnosia, neglect, apraxia, hemianopia - and no seizures or mental status changes.

Syndromes:
Pure Motor Hemipareisis
Pure Sensory Stroke
Ataxis Hemipareisis
Dysarthria Slumsy hand.
58
Q

57 m has right arm and leg weaknes 2 hours ago, couldnt grip a pen. He cant shake hands and walks with a limp. Hes had a mild constant headach for the past several days. He has HTN and hyperlipidemia. BP is 180/100. Theres asymmetry of the lower face, decreased muscle strength on right side. Ct scan of the head reveals no abnormalities. What is the cause?

A

Small vessel lipohyalinosis, aka lacunar infarct

59
Q

What differentiates a lacunar infarct with Carotid Artery Thrombosis?

A

Carotid Artery THrombosis would have cortical signs and altered mental status.

60
Q

Why does a lacunar infarct only have motor symptoms?

A

The lesion is only in the internal capsule and result in pure motor hemiparesis.

61
Q

A woman has easy bruisability, weight gain, acne, irregular periods, facial plethora, with dark terminal hair on the upper lip and chin. THeres tinea versicolor of the trunk.

Is the PCOS or Cushing, and why

A

Cushing - due to the increased bruisability

62
Q

Why would a 24 year old male have 2 ays of fever, sore throat, hoarsness, pain when swalloing, drooling and muffled voice with stridor? There is anterior neck tenderness on palpation.

A

Lack of vaccination. this adult has H. Flu leading to Infectious Epiglottitis.

63
Q

What are the three symptoms of Felty Syndrome

A

Rheumatoid Arthritis, Neutropenia <1500, and Splenomegaly.

This is an autoimmune disorder

64
Q

What is the treatment for Felty Syndrome

A

treat the underlying Rheumatoid Arthritis.

65
Q

What disease is associated with a tremor due to Basal Ganglia Dysfunction

A

Parkinsons

66
Q

Describe Essential Tremor

A

Bilateral action tremor of the hands. , or isolated hand tremor without dystonia. NO neurological signs. Relieved with alcohol.

67
Q

Describe Physiological Tremor

A

Usually not visible under normal conditions. Theres acute onset with increased sympathetic activity. Worse with movement. Could involve the face and extremities.

68
Q

What would cause Detrusor Hypocontractility in a elderly patient, who has been taking OTC treatment for a cough.

A

Diphenhydramine