Vaccine for bioterrorism(done) Flashcards

1
Q

Which bioterrorism agene\ts do we have vaccine for?

A

Anthrax, ebola, and smallpox

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2
Q

What is the public health responce for BT?

A

surveillance, contact tracing, isolation, clinical laboratory analysis, communications, decontamination

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3
Q

Why is there a threat of BT?

A

Because there are two remaining virus stocks exist in Georgia and Russia

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4
Q

What are the stocks remaining?

A

For research, government weapons

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5
Q

What is the vaccine for small pox?

A

1)ACAM2000 live vaccinia vaccine
2)APSV vaccinia vaccine
3)JYNNEOS live, non-replicating vaccine(immunosuppressed people)

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6
Q

What other disease does the vaccinia vaccine give cross protection for?

A

orthopoxviruses(monkeypox, cowpox, variola)

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7
Q

What is the vaccine availability for smallpox?

A

Supply controlled by CDC. Enough to vaccinate all of US

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8
Q

What is the efficacy of smallpox vaccine?

A

lack of data on immune response.

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9
Q

Who should get the smallpox vaccine?

A

revaccination every 3-10 years if a labratory worker, some healthcare workers

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10
Q

True or false: post exposure prophalaxsis is effective againist exposure to smallpox.

A

true, it reduces symptoms and prevents disease.

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11
Q

What is the vaccinaion procedure for ACAM2000 or APSV?

A

vaccine vial has 100 doses, vaccinator should wear glovs, remove aluminum seal and rubber stopper, administer into rightarm over deltoid, cleaning unnecessary, Bifurcated needles supplied with vaccines

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12
Q

Explain vaccine procedure for smallpox.

A

vaccine process call scarification, needle at right angle to skin, multiple punctures(15) in 5mm area, cover with gauze and tape until scab falls away

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13
Q

Describe the evolution of the vaccine site after receiving smallpox vaccine.

A

Day 3: red papule
Day 5: vesicular site
7:Jennerian pustule
10: expanding erthema
14: crust

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14
Q

What are some of the adverse reactions to smallpoz vaccine?

A

fever and lymphadenopathy, rashes, auto-inoculation, genneralized vaccinia, myopericarditis, ezcema vaccinatum, postvaccination encephalitis, death

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15
Q

WHat are the vaccine contridictions for smallpox in an emergency?

A

none because of high risk of death

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16
Q

What public health approaches are used to reduce spread of vaccination?

A

ring vacination, vaccinate those who have been in contact with person infected

17
Q

How long are those who have been in contact with smallpox watched for?

A

18 days after last contact with case, 14 days after vaccination

18
Q

Who is reccomended to get Mpox vaccine?

A

people who have been in contact with mpox, people who have had sexual contact with someone with mpox,

19
Q

How is JYNNEOS administered?

A

2 doses seperated by 4 weeks, subcutaneous, injection site reactions

20
Q

What vaccines are used to prevent Anthrax?

A

1)BioThrax, BioPort corporation
2)Cell-free filtrate of B. anthracis culture
no dead or live bacteria

21
Q

What is the immunization schedule of Anthrax?

A

IM, 0, 1, 6, 12, 18 months, annual boosters

22
Q

What is the schedule for Anthrax postexposure prophalaxis?

A

3 dose regimen, 0,2,4 weeks

23
Q

What are contradictions for Anthrax vaccine?

A

history of infection, anaphylaxis, postpone for moderate to severe illness

24
Q

Is the ANtrax vaccine effective?

A

yes. 95% have high concentration of antibodies

25
Q

What are adverse reactions associated with Anthrax vaccine?

A

local reactions, systemic symptoms

26
Q

What is ebola?

A

rare, deadly viral infection

27
Q

how is ebola transmitted?

A

bodily fluids

28
Q

What are the symptoms of ebola?

A

fever, myalgia, internal hemorrhage, vomiting or couphing blood, death(70-90%)

29
Q

What vaccine is used to prevent ebola virus?

A

rVSV-ZEBOV for Zaire ebolavirus, was not effective for 2022 outbreak

30
Q

How is the ebola vaccine used?

A

single imL dose IM for healthy, nonpregnant, adults with occupational exposure

31
Q

What are the adverse effects of ebola vaccine?

A

analphylaxis, decreased WBC, arthralgia, arthritis

32
Q
A