Vagina

Question 1

What is the Mucosa of the Vagina lined with?

Answer 1

Non-keratinizing squamous epithelium

Question 2

What is Adenosis

Answer 2

It is a focal persistence of columnar epithelium in the upper vagina. Normal development squamous epithelium lower 1/3 ( derived from urogenital sinus) and replaces columnar of 2/3 (derived from Mullerian ducts)

Question 3

What causes increased risk for Adenosis

Answer 3

Women exposed to DES in utero

Question 4

What is it called when you see malignant proliferation of glands with clear cytoplasm?

Answer 4

Clear cell Adenocarcinoma

Question 5

What is Embryonal Rhabdomyosarcoma

Answer 5

Malignant mesenchymal proliferation of immature skeletal muscle.

Question 6

What is the age group you would see Embryonal Rhabdomyosarcome? How would it look

Answer 6

Usually in children less than 5 years of age. Presents as bleeding and a grape like mass protruding from the vagina or penis

Question 7

What is the main type of cell and what do you look for with this cell?

Answer 7

Rhabdomyoblast and you look for cross-striations and postive for immunohistochemical staining for desmin and myogenin

Question 8

What cells does vaginal carcinoma arise from?

Answer 8

squamous epithelium usually due to hpv