Vascular disorders chapter 26 Flashcards
(123 cards)
List arterial disorders?
- Arteriosclerosis and atherosclerosis
- Peripheral artery disease
- Upper extremity arterial disease
- Aortoiliac disease: Aortoiliac occlusive disease is a type of artery condition in the legs. It occurs when the iliac artery that brings blood to your legs becomes narrow or blocked by plaque.
- Aneurysms (thoracic, abdominal, other)
- Aortic dissection
- Arterial embolism and arterial thrombosis
- Raynaud’s phenomenon and other acrosyndromes
Arteriosclerosis? Think !!!! thickening
- Hardening of the arteries
- Diffuse process whereby the muscle fibers and the endothelial lining of the walls of small arteries and arterioles become thickened. Most of it has to do with aging.
It happens because:
1) There is calcium that sticks to the arterioles
2) They become thick
3)LDL particles build on your arteries.
Atherosclerosis? Atheromas = plaques (Not thick but hardening)
Different processes, affecting the intima of large and medium-sized arteries
Accumulation of lipids, calcium, blood components, carbohydrates, and fibrous tissue on the intimal layer of the artery
Atheromas or plaques.
A very slow process, It can start when you are a child as soon as 10 years of age.
-The problem here is not only the buildup of plaque but it is also the inflammation that narrows, even more, the walls of those arteries.
Risk Factors for Atherosclerosis and PAD (Peripheral artery disease)
Traditional Risks :
Nicotine use
Hyperlipidemia
Diet
Stress
Sedentary lifestyle
C-reactive protein (
High levels of CRP may mean you have a serious health condition that causes inflammation)
(Hyperhomocysteinemia)
Age
Non-Traditional Risks:
- Socioeconomic status
- Diabetes
- Environmental pollution
- Hypertension
- Endothelial disease
Female specific-preeclampsia (a condition in pregnancy characterized by high blood pressure, sometimes with fluid retention and proteinuria.) & menopause
PAD Risk Modification:
- Tobacco cessation
- Hgb A1C <7.0% for diabetics and you want it under 7%. This is because if we just do a regular fasting blood check it might give us a false negative. Diabetes damages arteries especially the small ones.
- Aggressive treatment of hyperlipidemia: Diet, weight loss, medications.
- BP maintained <140/90.
PAD Description
- Involves progressive narrowing and degeneration of arteries of upper and lower extremities
- Atherosclerosis is the leading cause in the majority of cases.
- Patients with PAD are more likely to have coronary artery disease and/or cerebral artery disease
- Symptoms occur when vessels are 60-75% blocked
- Typically appears at 60-80 years of age
- Largely underdiagnosed
PAD Clinical Manifestations?
Pain at rest:
- As PAD progresses
- Occurs in feet or toes
- Aggravated by limb elevation
- Occurs from insufficient blood flow
- Occurs more often at night
Pharmacologic Therapy for PAD
1) Phosphodiesterase III inhibitor
- Cilostazol
2) Antiplatelet agents
- Aspirin
- Clopidogrel (Plavix)
- Coumadin (Warfarin)
3) Statins for cholesterol
4) Ace inhibitors
5) RAMIPRIL
6) For Intermittent claudication
- Cilostazol (Pletal)
- Pentooxifylline (Trental)
Exercise & Nutritional Therapy for PAD
Walking is most effective exercise for individuals with claudication
30-45 minutes daily, 3 times/week
Nutritional therapy -78% of vascular surgical patients can be classified as malnourished.
What we want are foods that take little energy to metabolize but are high in protein, and low in fat.
DASH diet: fruits, vegetables, nuts, and fiber, augmented by low sodium
Limit saturated fats to < 7% of total caloric intake but they can enjoy omega-3 fatty acids
Vitamin D can improve endothelial dysfunction
PAD Complications?
Critical limb ischemia (CLI). Because if we are ischemic it’s going to turn into tissue necrosis. We can lose the limb.
**Characterized by rest pain lasting more than 2 weeks & or arterial leg ulcers or gangrene
-Atrophy of the skin and underlying muscles because they are not getting O2 and their toxins can’t get removed because the highway is closed.
-Delayed wound healing. No nutrients and oxygen
-Wound infection and then we get arterial ulcers. They look round.
-Tissue necrosis
Arterial ulcers:
**Arterial ulcers and gangrene are the most serious complications
**May result in amputation if adequate blood flow is not restored or if severe infection
PAD diagnostic studies : Ankle-brachial index (ABI) no need to memorize numbers.
NORMAL 0.9-1.3
ABI =ankle BP/highest arm BP
The ankle-brachial index, or ABI, is a simple test that compares the blood pressure in the upper and lower limbs. Health care providers calculate ABI by dividing the blood pressure in an artery of the ankle by the blood pressure in an artery of the arm.
PAD Diagnostic Studies?
-Doppler ultrasound (if you can’t feel the pulse)
-Angiography and MRI
Duplex imaging
Bidirectional, color -Doppler
-Ankle-brachial index (ABI)
NORMAL 0.9-1.3
ABI =ankle BP/highest arm BP
Continuous wave (CW) Doppler Ultrasound?
-Handheld ultrasound device that detects blood flow, combined with computation of ankle or arm pressures
-Signals are reflected by the moving blood cells
-Diagnostic technique helps characterize the nature of the peripheral vascular disease
PAD Interprofessional CareLeg with Critical Limb Ischemia?
-Revascularization via bypass surgery. By bypassing the obstruction.
-Percutaneous transluminal angioplasty (PTA) We insert a catheter and we dilate the vessel and put a stent to keep it open. (side note: it can cause DVT)
woooooooooooooooyayyyeyeyeyeyeyey
-IV prostanoids (iloprost [Ventavis])
-Spinal cord stimulation
-Angiogenesis
PAD Interprofessional CareLeg with Critical Limb Ischemia 2
Conservative Treatment:
-Protect from trauma: Because if they don’t have a good blood supply and they get an injury it’s gonna be hard for them to heal.
-Decrease ischemic pain: since the nerves are not getting O2 they die and that causes us to have pain.
-Prevent/control infection/ the same as with a wound not easy to heal because if the highway is closed our macrophages etc can’t come to rescue
-Improve arterial perfusion
PAD Interprofessional CareInterventional Radiology Procedures 3
Indications: We start doing radiology procedures when :
-Intermittent claudication symptoms become incapacitating. Meaning that they fuck your quality of life a lot.
-Pain at rest
-Ulceration or gangrene severe enough to threaten the viability f the limb
IR Procedures (Interventional radiology)
PTA: (Percutaneous Transluminal Angioplasty)
Involves insertion of a catheter through the femoral artery
Catheter contains a cylindrical balloon
Balloon is inflated dilating he vessel by compressing the atherosclerotic intimal lining
Stent is placed
Atherectomy: arthero=plaque
Removal of obstructing plaque
Performed using a cutting disc, laser, or rotating diamond tip
Cryoplasty:
Combines PTA and cold therapy (applying extreme cold to kill or dissolve something)
Liquid nitrous oxide to remove the plaque
IR Procedures 1 PTA para desbloquear
PTA: (Percutaneous Transluminal Angioplasty)
- Involves insertion of a catheter through the femoral artery
- Catheter contains a cyndrical balloon
- Balloon is inflated dilating he vessel by compressing atherosclerotic intimal lining
- Stent is placed
IR Procedures 2 Atherectomy. Remember athero= plaque
- Removal of obstructing plaque
- Performed using a cutting disc, laser, or rotating diamond tip
IR Procedures 3 Cryoplasty
Cryoplasty
- Combines PTA and cold therapy
- Liquid nitrous oxide
Cryoplasty is a minimally invasive treatment used for patients with peripheral vascular disease. It is an alternative to traditional angioplasty and stenting techniques.
Surgical Therapy PAD. Peripheral artery bypass (most common surgical approach)
- Surgery with autogenous (arising from within or from a thing itself.
) vein or synthetic graft to bypass blood around the lesion - PTA with stenting may also be used in combination with bypass surgery
Surgical Therapy PAD Endarterectomy
Opening artery and removing obstructing plaque
Surgical Therapy PAD. Patch graft angioplasty
Opening artery, removing plaque, and sewing a patch to the opening to widen the lumen
Surgical Therapy PAD Amputation
Required if tissue necrosis is extensive, gangrene, or osteomyelitis develop, or all major arteries in limb are blocked