Vasculitides

Question 1

Large Cell

Answer 1

GCA, Takayasu’s

Question 2

Medium cell

Answer 2

Polyarteritis Nodosa, Kawasaki’s, Buerger’s

Question 3

Small cell

Answer 3

GPA, EGPA, microscopic polyangiitis

Question 4

GCA

Answer 4

large cell. Affects temporal arteries
unilateral headache, pain while chewing/brushing hair
Assoc with polymyalgia rheumatica
rx - pred 60

Question 5

Takayasu’s arteritis

Answer 5

large cell. Affects branches of aortic arch

Asian woman under 40, weak or no pulse, differing BP

Question 6

Kawasaki disease

Answer 6

Medium cell. Affects coronary arteries.
Children under 5
CRASH and burn
self-limiting

Question 7

Polyarteritis Nodosa

Answer 7

Medium cell. Affects Renal arteries, Mesenteric arteries, coronary arteries
Necrotizing vasculitis
Angiogram - string of beads

Question 8

Buerger’s disease

Answer 8

Medium cell. Affects tibial and radial arteries
Jewish population
Clots can lead to dead tissue
rx - smoking cessation

Question 9

GPA

Answer 9

Large cell. Affects URT, LRT, Kidneys
URT - pain, ulcers, saddle nose deformity
LRT - haemoptysis, difficulty breathing
Kidneys - HTN, low UO
cANCA positive

Question 10

Microscopic Polyangiitis

Answer 10

Large cell. Similar to GPA - only affects LRT an kidneys
precipitated by meds - penicillin
Crescentic glomerulonephritis, haemoptysis
pANCA positive

Question 11

EGPA

Answer 11

Large cell. Similar to GPA
“adult onset asthma”
pANCA positive, ⬆️eosinophilia