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Cardiovascular > Vasculitis > Flashcards

Vasculitis Flashcards

(45 cards)

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1
Q

Symptoms of Giant cell Arteritis

A

Unilateral headache, temporal artery tenderness and Jaw Claudication, Can lead to Blindness (if ophthalmic A occluded)

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2
Q

Which disease is associated with Giant Cell Arteritis

A

Polymyalgia Rheumatica

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3
Q

which arteries are affected in Giant cell arteritis

A

Branches of Carotid Artery

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4
Q

Histology of Giant cell arteritis

A

Focal Granulomatous Inflammation

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5
Q

How to treat Giant cell arteritis

A

High dose corticosteroids

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6
Q

Symptoms of Takayasu arteritis

A
  • weak upper extremity pulse (pulseless disease)
  • fever, night sweats
  • Arthritis, myalgia
  • skin nodules
  • ocular disturbances
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7
Q

Histology of Takayasu

A

Granulomas (in aortic arch and proximal great vessels)

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8
Q

how to treat Takayasu

A

corticosteroids

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9
Q

where do you see elevated ESR

A

Giant cell arteritis and Takayasu

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10
Q

Symptoms of Buerger disease

A
  • Intermittent claudication
  • Gangrene, Autoamputation of digits
  • Superficial nodular phlebitis
  • Raynaud phenomenon
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11
Q

Histology of Buerger

A

Segmental thrombosing vasculitis with vein and nerve involvement (thromboangitis obliterans)

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12
Q

Symptoms of Kawasaki

A

CRASH and Burn
- Conjunctival injection
- Rash (desquamating)
- Adenopathy (Cervical)
- Strawberry tongue (oral mucositis)
- Hand foot change (edema/erythema)
- Fever

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13
Q

Complications of Kawasaki

A

Coronary artery aneurysm that can rupture or get thrombosed

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14
Q

How to treat Kawasaki

A

IV immunoglobulin and Aspirin

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15
Q

Symptoms of polyarteritis nodosa

A
  • Fever, weight-loss, headache
  • GI (abdominal pain, melena)
  • HTN, neuro
  • Cutaneous eruptions
  • Renal damage
  • NO lungs
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16
Q

Histology of polyarteritis Nodosa

A

Transmural inflammation with fibrinoid necrosis

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17
Q

Which radio test u would do for patients with Polyarteritis nodosa

A

Arteriogram of renal (Innumerable renal micro aneurysms)

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18
Q

What to test for in patients with polyarteritis nodosa

A

Hep B

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19
Q

Treatment of polyarteritis nodosa

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A

Corticosteroids and cyclophosphamide

20
Q

Symptoms of Behcet syndrome

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A

Apthous ulcer, Genital ulcer, Uveitis, Erythema nodosum

21
Q

What viruses Precipitate Behcet

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A

HSV or Parvovirus

22
Q

Histology of Behcet

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A

Immune complex vasculitis

23
Q

which serotype is associated with Behcet

24
Q

Causes of cutaneous small vessel vasculitis

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A
  • Meds (penicillin/cephalosporin/Phenytoin/ Allopurinol)
  • Infections (HCV/HIV)
25
Symptoms of cutaneous small vessel vasculitis
Palpable purpura
26
Histology of cutaneous small vessel vasculitis
Immune complex mediated Leukocytoclastic vasculitis
27
Symptoms of Churg-Strauss (Eosinophilic granulomatosis with polyangitis)
- Asthma, Sinusitis - Skin nodules or purpura - neuropathy (wrist/foot drop) - Heart, GI , Kidney (pauci immune glomerulonephritis)
28
Histology of Churg-Strauss
Granulomatous necrotizing with Eosinophilia
29
Serotypes in Churg-Strauss
MPO-ANCA/ p-ANCA Increase in IgE
30
Symptoms of Wegner (Graulomatosis with polyangitis)
- URT (perforated nasal septum, Sinusitis, Otitis media, mastoiditis) - LRT (hemoptysis, cough, dyspnea) - Renal (Hematuria, red cell cast)
31
Histology of Wegner
necrotizing granuloma
32
Serology in Wegner
PR3-ANCA / c-ANCA (anti-proteinase 3)
33
What radiologic test to do in Wegner
CXR (large nodular densities)
34
How to treat Wegner
Cyclophosphamide and corticosteroids
35
Symptoms of Henoch-Schonlein pupura
- Follows URT infection - Palpable purpura on buttocks/legs Arthralgia - Abdominal pain (associated with intussusception)
36
Which disease is associated with Henoch-Schonlein pupura
IgA nephropathy (Berger)
37
Cause of Henoch-Schonlein pupura
IgA immune complex deposits
38
Tx of Henoch-Schonlein pupura
Supportive , possible corticosteroids
39
Symptoms of Microscopic polyangitis
Similar to Granulomatosis with polyangitis but WITHOUT nasopharyngeal involvement No granuloma
40
Serology of Microscopic polyangitis
MPO-ANCA / p-ANCA (anti-myeloperoxidase)
41
Tx of Microscopic polyangitis
Cyclophosphamide and corticosteroids
42
Cause of mixed Cryoglobulinemia
Viral (HCV)
43
Symptoms of mixed Cryoglobulinemia
- Palpable purpura - Weakness - Arthralgia - may have peripheral neuro and kidney
44
What are Cryglobulins
Immunoglobulins that precipitate in the Cold
45
Histology of mixed Cryoglobulinemia
mixed IgG and IgM immune complex depositions

Cardiovascular (2 decks)

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