Vasculitis

Question 1

unilateral headache
jaw claudication
polymyalgia rheumatica

Answer 1

temporal arteritis

Question 2

what vessels affected in temporal arteritis

Answer 2

branches of the carotid artery

Question 3

consequences of temporal arteritis

Answer 3

irreversible blindness

Question 4

treatment of temporal arteritis

Answer 4

corticosteroids before biopsy

Question 5

what will you see on biopsy of temporal arteritis

Answer 5

focal granulomatous inflammation

Question 6

lab in large vessel vasculitis

Answer 6

increased ESR

Question 7

elderly females

Answer 7

temporal arteritis

Question 8

weak upper extremity pulses
fever
night sweats
arthritis
myalgias
skin nodules
ocular disturbances

Answer 8

takayasu artertis

Question 9

Asian feamles < 40 yp

Answer 9

takayasu arteritis

Question 10

histo on takayasu arteritis

Answer 10

granulomatous thickening and narrowing of arotic arch and proximal great vessels

Question 11

tx of takayasu arteritis

Answer 11

corticosteroids

Question 12

hepatitis B seropositivity

Answer 12

polyarteritis nodosa

Question 13

fever
weight loss
malaise
headache
abdominal pain
melena
hypertension
neurologic fysfunction
cutaneous eruptions
renal damage

Answer 13

polyarteritis nodosa

Question 14

young adults mainly men

Answer 14

polyarteritis nodosa

Question 15

vessels affected in polyarteritis nodosa

Answer 15

renal, visceral

not pulmonary arteries

Question 16

polyarteritis nodosa is what type of immune response

Answer 16

type III hypersensitivity

Question 17

histo in polyartertis nodosa

Answer 17

transmural inflammation of arterial wall with fibirinoid necrosis
at ALL stages of inflammation

Question 18

treat of polyarteritis nodosa

Answer 18

corticosteroids, cyclophosphamde

Question 19

Asian children < 4 yo

Answer 19

Kawasaki disease

Question 20

conjunctival injection
rash - polymorphous/desquamating
cervical adenopathy
oral ucositis/strawberry tongue
hand/foot changes - edema erythema
fever

Answer 20

Kawasaki disease

Question 21

complication of Kawasaki disease

Answer 21

coronary artery aneurysm, thrombosis, rupture can cause death

Question 22

treatment of Kawasaki disease

Answer 22

IVIG

aspirin

Question 23

heavy smokers, malesl < 40 yo

Answer 23

buerger disease

thromboangiitis obliterans

Question 24

intermittent claudication may lead to gangreme, autoamputatio of digits, superficial nodular phlebitis

Answer 24

beurger disease

thromboangiitis obliterans

Question 25

histpath in thromboangiitis obliterans

Answer 25

segmental thrombosing vasculiitis

Question 26

treatment of buerger disease

Answer 26

smoking cessation

Question 27

perforation of nasal septum, chronic sinusitis, otitis media, mastoiditis hemoptysis, cough, dyspnea hematuria, red cell cast

Answer 27

franulomatosis with polyangiitis/wegener

Question 28

triad of histopath in wegener

Answer 28

focal necrotizing vascultis necrotozing granulomas in lung and upper airway necrotoxing glomerulonephritis

Question 29

PR3-ANCA/c-ANCA/anti-proteinase3

Answer 29

Wegener/granulomatosis with polyangiitis

Question 30

CXR with large nodular densities

Answer 30

Wegener/granulomatosis with polyangiitis

Question 31

treatment of wegener

Answer 31

cyclophosphamide and corticosteroids

Question 32

no nasopharyngeal invovlemtn @ lungs, kidney, skin, kidney, palpable purpura

Answer 32

microscopic polyangiitis

Question 33

no granulomas!!!

Answer 33

microscopic polyangiitis

Question 34

MPO-ANCA/p-ANCA/anti-myeloperoxidase

Answer 34

microscopic polyangiitis, churg strauss (also increased IgE)

Question 35

``` asthma sinusitis skin nodules purpura peripheral neuropathy ```

Answer 35

eusinophilic granulomatosis with polyangiitis (churg-strauss)

Question 36

heart gi kidness

Answer 36

churg strauss

Question 37

histopath in eosinophilic granulomatosis with polyangiitis/churg-strauss

Answer 37

granulomatous necrotizing vasculitis with eosionphilila

Question 38

treatment of microscopic polyangiitis

Answer 38

cyclophosphamide | corticosteroids

Question 39

palpable purpura on buttocks/legs arthralgias abdominal pain

Answer 39

Henoch-Schonlein purpura

Question 40

vasculitis following a URI

Answer 40

Huenoch Schonlein purpura

Question 41

pathogenesis in Henoch Schonlein purpura

Answer 41

vasculitis secondary to IgA immune complexes

Question 42

what is Henoch Schonelein purpura asosociated with

Answer 42

IgA nephropathy/Berger diseas

Question 43

what type of immune reaction is Henoch Schonlein purpura?

Answer 43

Type III hypersensitivity