Vasculitis

Question 1

define

Answer 1

this is inflammation of blood vessels

Question 2

small vessel ANCA examples

Answer 2

GPA
MPA
eGPA

Question 3

immunology of GPA

Answer 3

anti-PR3 antibodies

cANCA

Question 4

immunology of MPA

Answer 4

anti-MPO antibodies

pANCA

Question 5

describe GPA

Answer 5

necrotising granulomatous inflammation with lung and renal involvement (pulmonary/ renal syndrome)

Question 6

describe MPA

Answer 6

no granulomas but has systemic features affecting lungs, kidneys, skin, GI and nerves

Question 7

describe eGPA

Answer 7

Associated with asthma and eosinophilia. Most have skin involvement

Question 8

presentation of GPA

Answer 8

saddle nose

Question 9

presentation of vasculitis

Answer 9

fever
arthralgia
weight loss
malaise

Question 10

diagnosis

Answer 10

active urinalysis with protein and blood
bloods= raised inflammatory markers, AKI, anaemia
renal biopsy and immunology

Question 11

management

Answer 11

immunosuppression (steroids, cyclophosphamide/ rituximab)
plasma exchange
dialysis
ventilation