Venous Thromboembolism

Question 1

Virchow’s Triad

Answer 1

o Vessel injury
o Hypercoagulability
o Venous stasis

Question 2

Highest hereditary risk factor of VTE

Answer 2

Homozygous factor V Leiden

Question 3

Highest acquired risk factor of VTE

Answer 3

Lupus anticoagulant/antiphospholipid ab

Question 4

Most common inherited thrombophilia:

Mechanism:

Answer 4

Factor V Leiden

• → Activated protein C resistance
o APC limits clot formation by inactivation of factors Va and VIIIa

Question 5

2nd most common inherited thrombophilia:

Mechanism:

Answer 5

Prothrombin G20210A

• → elevated levels of prothrombin → hypercoagulability

Question 6

T/F: Protein C deficiency is a significant risk factor to provoke thrombosis

Answer 6

False. Need additional risk factors

Question 7

T/F: Protein S deficiency is a significant risk factor to provoke thrombosis

Answer 7

False. Likely need additional risk factors

Question 8

T/F: During an acute clot, checking protein C and S can help determine the etiology of the clot.

Answer 8

False. Do NOT check protein C or S during acute clot b/c can be falsely low

Question 9

Name the disease:
Prolong aPTT
Prolong PT
NOT correct 1:1 mix

Answer 9

Antiphospholipid Syndrome

Question 10

T/F: Unprovoked thrombus have highest recurrence rate after stopping.

Answer 10

True. Followed by non-surgical risks (estrogen)

Provoked are least likely to recur