WBC Disorders

Question 1

Presence of toxic granulation and Dohle bodies are seen in ___

Answer 1

infections

Question 2

Name the disorder:

BCR-ABL fusion gene

Answer 2

Chronic Myeloid Leukemia

Causes dysregulated production and uncontrolled proliferation of mature and maturing granulocytes w fairly normal differentiation

Question 3

Most common leukemia in adults in Western hemisphere

Answer 3

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Question 4

Which of the following is NOT a feature of CML?
A. Many don’t have symptoms
B. Fatigue, night sweats, weight loss
C. Macrocytic anemia
D. Absolute basophilia, eosinophilia, neutrophilia
E. Hepato/splenomegaly
F. High platelet count

Answer 4

C. Normocytic normochromic anemia

Question 5

T/F: CML is cured w/ Tyrosine kinase inhibitors (Gleevac)

Answer 5

False. Not curative

Only cured w/ allogenic stem cell transplant

Question 6

T/F: CML has poor survival rate.

Answer 6

False. Very good long term survival

Question 7

Which of the following is/are curable with chemotherapy?
A. CML
B. CLL/SLL
C. ALL
D. AML

Answer 7

C, D

Question 8

> 20% lymphoblasts in bone marrow/peripheral blood is diagnostic of ___

Answer 8

Acute Lymphocytic Leukemia

Question 9

> 20% myeloid blasts in bone marrow/peripheral blood is diagnostic of ___

Answer 9

Acute Myeloid Leukemia

UNLESS pt has one of 4 cytogenetic abnormalities

Question 10

T/F: CNS and testicular involvement is typically seen in Acute Myeloid Leukemia

Answer 10

False. Acute Lymphocytic Leukemia

AML hardly have CNS or testicular involvement

Question 11

Name the disease:

Auer rods on blood smear

Answer 11

Acute Myeloid Leukemia

Question 12

T/F: Hepato/splenotomegaly is more common in AML than ALL and is most common in CML

Answer 12

False. More common in ALL than AML

True most common in CML: 50-90% sm, 50% hm

Question 13

Name the disease:

Most common acute leukemia in adults

Answer 13

Acute Myeloid Leukemia

Question 14

Median age of AML

Answer 14

65

Question 15

Median age of ALL

Answer 15

Most common in kids

14

Question 16

Median age of CML

Answer 16

50-60

Question 17

Median age of CLL/SLL

Answer 17

72

Question 18

T/F: CLL is predominately in bone marrow and SLL is predominately in lymph nodes. Other than that, they consist of the same cells.

Answer 18

True

Question 19

Genetics is a very small risk factor of _____.

Answer 19

AML

Main RF: 
• Exposure to:
	Benzene
	Ionizing radiation
	Chemotherapy

Question 20

Leukemia infiltration in gums, CNS, skin commonly seen in ___

Answer 20

AML

Question 21

95% of pts have circulating blasts in ____

Answer 21

AML

Question 22

T/F: Pts with CLL are more likely to get leukostasis

Answer 22

False. Most likely in AML

Question 23

T/F: Pt with Chronic Myeloid Leukemia does not need treatment if he is asymptomatic.

Answer 23

False. True for Chronic Lymphocytic Leukemia