VII - Topnotch Pharma Flash Cards - Chemotherapeutic Drugs Preview

Pharmacology > VII - Topnotch Pharma Flash Cards - Chemotherapeutic Drugs > Flashcards

Flashcards in VII - Topnotch Pharma Flash Cards - Chemotherapeutic Drugs Deck (225)
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1

Binds to penicillin-binding proteins, inhibits transpeptidation in bacterial cell walls

Penicillin, Cephalosporins (TOPNOTCH)

2

DOC for syphillis, for streptococcal, meningococcal, G+ bacilli, spirochete infection

Natural Penicillins: Penicillin G, Penicillin V (narrow spectrum penicillin) (TOPNOTCH)

3

For staphylococcal infections

Anti-Staphylococcal Penicillins: Methicillin, nafcillin, oxacillin, cloxacillin (very narrow spectrum) (TOPNOTCH)

4

all penicillins are excreted unchanged in the urine EXCEPT for _____which is excreted in the bile

Nafcillin (TOPNOTCH)

5

Pens For enterococci, Listeria, E. coli, Proteus, H. influenza, Moraxella

Extended Spectrum Penicillin: Ampicillin, Amoxicillin (TOPNOTCH)

6

Pens For Pseudomonas, Enterobacter, Klebsiella

Antipseudomonal Penicillin: Piperacillin, ticarcillin, carbenicillin (TOPNOTCH)

7

all Cephs have renal excretion EXCEPT ______

Cefoperazone and Ceftriaxone (TOPNOTCH)

8

Cephs for For surgical prophylaxis, bone infections, infections due to staph and strep, E. coli, Klebsiella, G+ cocci

First Generation Cephs (TOPNOTCH)

9

Increases nephrotoxicity of aminoglycosides

Cephs (TOPNOTCH)

10

For surgical prophylaxis, bone infections, infections due to staph strep and E. coli, Enterobacter, Neisseria, infections against anaerobes (Bacteroides), sinus ear and respiratory infections by Klebsiella andHemophilus

Second Generation Cephs (TOPNOTCH)

11

Second Generation Cephs

Cefamandole, cefaclor, cefonicid, cefuroxime, cefprozil, loracarbef, ceforanide, cefoxitin, cefmetazole, cefotetan (TOPNOTCH)

12

First Generation Cephs

Cefazolin, cefadroxil, cephalothin, cephapirin, cephradine, cephalexin (TOPNOTCH)

13

Cephs with slight less activity against G+ but extended G- activity

Second Generation Cephs (TOPNOTCH)

14

decreased gram + coverage, increased gram - activity (pseudomonas, bacteroides), against Providencia, Serratia, Neiserria, Haemophilus ; DOC for gonorrhea

Third Generation Cephs (TOPNOTCH)

15

DOC for gonorrhea

Ceftriaxone and Cefixime (TOPNOTCH)

16

Third Generation Cephs

Cefoperazone, cefotaxime, ceftizoxime, ceftriaxone, cefixime, cefpodoxime proxetil, cefdinir, ceftibuten (TOPNOTCH)

17

all can Third gen Cephs can penetrate the BBB EXCEPT _____

Cefoperazone and Cefixime (TOPNOTCH)

18

More resistant to beta-lactamase produced by Enterobacter, Haemophilus, Neisseria and Pneumococcal

Fourth Generation Cephs (TOPNOTCH)

19

Fourth Generation Cephs

Cefipime (TOPNOTCH)

20

Binds to penicillin-binding proteins, inhibits transpeptidation in bacterial cell walls, wide coverage against gram + gram - bacteria and anaerobes ; For infections resistant to other antibiotics EXCEPT MRSA, DOC for Enterobacter, Citrobacter and Serratia

Carbapenems (TOPNOTCH)

21

Carbapenems

Imipenem-cilastatin , ertapenem, meropenem (TOPNOTCH)

22

Imipenem given with Cilastatin which acts as ______

Dehydropeptidase enzyme inhibitor (TOPNOTCH)

23

Monobactam

Aztreonam (TOPNOTCH)

24

Resistant to beta-lactamase, no activity against gram + bacteria or anaerobes

Aztreonam (TOPNOTCH)

25

No cross-allergenicity with Pens

Aztreonam (TOPNOTCH)

26

Inhibits inactivation of penicillins by bacterial beta-lactamase (penicillinase)

Beta-Lactamase Inhibitors (TOPNOTCH)

27

Beta-Lactamase Inhibitors

Clavulanic acid , sulbactam, tazobactam (TOPNOTCH)

28

Inhibits cell wall synthesis by binding to the D-Ala-D-Ala terminus of nascent peptidoglycan --> inhibit transglycosylation --> prevent elongation and cross-linking of peptidoglycan chain

Glycopeptides: Vancomycin, teicoplanin, telavancin (TOPNOTCH)

29

For MRSA, PRSP, as alternative for pseudomembranous colitis

Vancomycin (TOPNOTCH)

30

SE: red man syndrome, nephrotoxicity, ototoxicity, chills, fever, phlebitis

Vancomycin (TOPNOTCH)