V - Topnotch Pharma Flash Cards - Drugs for Blood and Coagulation Preview

Pharmacology > V - Topnotch Pharma Flash Cards - Drugs for Blood and Coagulation > Flashcards

Flashcards in V - Topnotch Pharma Flash Cards - Drugs for Blood and Coagulation Deck (81)
Loading flashcards...
1

Required for the biosynthesis of heme and heme containing proteins, including hemoglobin and myoglobin; For Iron deficiency anmia, iron supplementation

Ferrous sulfate, Ferrous gluconate, Ferrous Fumarate, Iron dextran, Sodiun Ferric Gluconate complex, Iron sucrose (TOPNOTCH)

2

Chelates excess iron; For acute and chronic iron poisoning

Deferoxamine, Deferasirox (TOPNOTCH)

3

Cofactor required for essential enzymatic reactions that form tetrahydrofolate, convert homocysteine to methionine and metabolize methymalonyl-CoA; For vitamin B12 deficiency, megaloblastic anemia

Cyanocobalamin, Hydroxocobalamin (TOPNOTCH)

4

Precursor of an essential donor of methyl groups used for synthesis of amino acids, purines and deoxynucleotide; For Megaloblastic anemia, prevention of neutral tube defects(spina bifida), prevention of coronary artery disease

Folic acid (TOPNOTCH)

5

Agonist of erythropoietin receptors expressed by red cell progenitors; For Anemia, associated with chronic renal failure, cancer, HIV infection and prematurity

Epoetin Alfa, Darbepoetin alfa, Methoxy Polyethylene Glycol- Epoetin Beta (TOPNOTCH)

6

Binds receptors on myeloid progenitors and stimulates cell maturation and proliferation ; Accelerates neutrophil recovery and reduces incidence of infection; For neutrophenia associated with chemotheraphy, myelodysplasia, and aplastic anemia

(G-CSF) Filgrastim, Sargamostim (GM-CSF), Pegfilgrastim (TOPNOTCH)

7

Recombinant form of an endogenous cytokine; activates IL -11 receptors ; For secondary prevention of thrombocytopenia in patients undergoing chemotheraphy

Oprelvekin(IL-11),Thrombopoietin (TOPNOTCH)

8

nhibits rate-limit in enzyme in cholesterol biosynthesis (HMG-CoA reductase), Increased hepatic cholesterol uptake, Increased high affinity LDL receptors which leads to decreased LDL levels

Simvastatin, Atorvastatin, Rosuvastatin, Fluvastatin, Pravastatin, Lovastatin, Pitavastatin, Cerivastatin (TOPNOTCH)

9

DOC for hypercholesterolemia(high LDL), decrease risk of acute coronary syndromes, ischemic stroke

Simvastatin, Atorvastatin, Rosuvastatin, Fluvastatin, Pravastatin, Lovastatin, Pitavastatin, Cerivastatin (TOPNOTCH)

10

Prominent SE of statins: ____

Hepatoxicity, Myopathy, Rhabdomyolysis (TOPNOTCH)

11

Increased risk of myopathy and rhabdomyolysis when statins are used with

Fibrates (TOPNOTCH)

12

non-absorbable polyemers that bind bile acids and similar steroids in the intestines preventing their reabsorption, increases cholesterol utilization for replacement, modestly lowers LDL levels by increasing hepatic LDL receptors

Bile Acid Binding Resin (TOPNOTCH)

13

Bile Acid Binding Resin

Colesevelam, Colestipol, Cholestyramine (TOPNOTCH)

14

SE: Constipation, Bloating, Gritty taste, Gallstone formation, steatorrhea, malabsortion of fat soluble substances (vitamin k, folate)

Colesevelam, Colestipol, Cholestyramine (TOPNOTCH)

15

Selective inhibitor of the NCP1L1 transporter decreasing intestinal absorption of cholesterol and other phytosterols, decreases cholesterol hepatic pool, increases hepatic LDL receptors

NPC1L1 transporter inhibitor (TOPNOTCH)

16

NPC1L1 transporter inhibitor

Ezetimibe (TOPNOTCH)

17

Cholesterol analog, takes the place of dietary and billiary cholesterol, decreasing intestinal absorption of cholesterol and other phytosterols

Sitosterol (TOPNOTCH)

18

Decreases VLDL synthesis and LDL cholesterol concentrations, decreases hormone-sensitive lipase activity leading to decreased LDL levels, Increases HDL cholesterol by decreasing its catabolism

Niacin (TOPNOTCH)

19

DOC for increasing HDL levels

Niacin (TOPNOTCH)

20

SE: Flushing, nausea, vomiting, Pruritus, Acanthosis nigricans, Rashes, Gastrointestinal irritation, Hepatoxicity (mild), Hyperuricemia, Impaired glucose tolerance, Arrythmias, Amyblopia

Niacin (TOPNOTCH)

21

Activates PPAR-_ and increases expression of lipoprotein lipase and apolipoproteins (apoA-I, apoA-II) leading to enhanced clearance of TG-rich lipoproteins, Lowers triglycerides, Increases HDL

Fibrates (TOPNOTCH)

22

DOC for hypertriglyceridemia

Fibrates (TOPNOTCH)

23

Fibrates

Gemfibrozil, Fenofibrate, Bezafibrate (TOPNOTCH)

24

Fibrates have higher risk of gallstone formation if given together with ____

resins (TOPNOTCH)

25

Nonselective, irreversible COX 1&2 inhibitor. Reduces platelet production of thromboxane A2, temporarily inhibit Prostacyclin synthesis

Aspirin (TOPNOTCH)

26

Uncoupler of oxidative phosphorylation, associated with Reye syndrome in children

Aspirin (TOPNOTCH)

27

Reversbily inhibits the binding of fibrin and other ligands to the platelet GPIIb-IIIa receptor

GPIIb-IIIa inhibitor: Abciximab, Eptifibatide,Tirofiban (TOPNOTCH)

28

For prevention or arterial thrombosis (MI, TIA, CVD), Inflammatory disorders (rheumatic fever, juvenile rheumatoid arthritis, kawasaki disease)

Aspirin (TOPNOTCH)

29

Inhibits phosphodiesterase III and increases cAMP in platelets and blood vessels, Inhibits platelet aggregation and causes vasolidation

PDE III inhibitor: Dipyridamole, Cilostazol (TOPNOTCH)

30

additional MOA: inhibit uptake of adenosine by endothelial cells and RBC, thus increasing adenosine levels leading to inhibition of platelet aggregation

PDE III inhibitor: Dipyridamole, Cilostazol (TOPNOTCH)