II - Topnotch Pharma Flash Cards - Cardiac-Renal Drugs Preview

Pharmacology > II - Topnotch Pharma Flash Cards - Cardiac-Renal Drugs > Flashcards

Flashcards in II - Topnotch Pharma Flash Cards - Cardiac-Renal Drugs Deck (55)
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1

lower BP by decreasing volume

Diuretics (TOPNOTCH)

2

Inhibit NA/CL transporter in distal convoluted tubule

Thiazide Diuretics (TOPNOTCH)

3

for mild to moderate hypertension(first line), Heart falure, Nephrogenic Diabetes Insipidius, Renal calcium stones

Thiazide Diuretics (TOPNOTCH)

4

Thiazide Diuretics

HCTZ, Chlorthalidone, Metolazone, Indapamide (TOPNOTCH)

5

hyperlipidemia, hyperuricemia, sulfa allergy, hyperglycemia, hypercalcemia

HCTZ, Chlorthalidone, Metolazone, Indapamide (TOPNOTCH)

6

Inhibit NA/K/2Cl transporter in thick ascending limb of loop of Henle

Loop Diuretics (TOPNOTCH)

7

Loop Diuretics

Furosemide, Torsemide, Bumetanide, Ethacynic Acid (TOPNOTCH)

8

Hypokalemic metabolic alkalosis, Potassium wasting, ototoxicity, hyperuricemia, nephrotoxicity, dehydration, hypomagnesemia,sulfa allergy, hypocalcemia

Loop Diuretics (TOPNOTCH)

9

activates a2 adrenergic receptors ; for hypertensive urgency

Clonidine (TOPNOTCH)

10

activates a2 adrenergic receptors, for pre eclampsia

Methyldopa (TOPNOTCH)

11

Taper use prior to discontinuation to avoid rebound hypertension ; readily enter the CNS

Clonidine (TOPNOTCH)

12

Irreversibly blocks the vesicular monoamine transporter(VMAT)

Reserpine (TOPNOTCH)

13

Block release of NE from the pre-synaptic neuron

Guanethidine, Guanadrel (TOPNOTCH)

14

alpha-1 blocker which is most selective for prostatic smooth muscle

Tamsulosin (TOPNOTCH)

15

Disadvantage of Prazosin compared to other alpha-1 blockers

short DOA (TOPNOTCH)

16

Release NO from endothelial cells, Relaxes arteriolar smooth muscle, causing vasolidation. Decreases afterload ; for pre-eclampsia, hypertension, heart failure

Hydralazine (TOPNOTCH)

17

drug induced lupus (hydralazine), reflex tachycardia

Hydralazine (TOPNOTCH)

18

Opens K+ channels in vascular smooth muscle, causing hyperpolarization, muscle relaxation and vasolidation

Minoxidil, Diazoxide (TOPNOTCH)

19

for alopecia / male pattern baldness, hypertension

Minoxidil (TOPNOTCH)

20

Constipation, Nausea, flushing,gingival hyperplasia, AV block, sinus node depression, Pretibial edema, dizziness

Non-dihydropyridine calcium channel blocker: Verapamil, Diltiazem (TOPNOTCH)

21

block voltage-gated L-type calcium channels (vascular > cardiac); for Angina, hypertension

Dihydropyridine calcium channel blocker: Nifedipine, Amlodipine, Nicardipine, Nisoldipine, Isradipine, Felodipine (TOPNOTCH)

22

relaxes venous and arteriolar smooth muscle

Nitroprusside (TOPNOTCH)

23

for acute heart failure, controlled hypotension, cardiogenic shock, hypertensive emergency

Nitroprusside (TOPNOTCH)

24

a thiazide derivative without a diuretic effect ; also induces insulin release (can be used to treat hypoglycemia in insulin-producing tumors)

Diazoxide (TOPNOTCH)

25

causes arteriolar vasolidation of the afferent and efferent arterioles

Fenoldopam (TOPNOTCH)

26

inhibit angiotensin converting enzyme ; for hypertension, heart failure

ACE inhibitors: Captopril, Enalapril, Lisinopril, Benazepril (TOPNOTCH)

27

slows down the progression of DM nephropathy and cardiac remodelling in heart failure

ACE inhibitors: Captopril, Enalapril, Lisinopril, Benazepril (TOPNOTCH)

28

competetively blocks Angiotensin 1 receptor site ; for hypertension

Angiotensin receptor blocker: Losartan, Valsartan, Irbesartan, Candesartan (TOPNOTCH)

29

inhibitor of renin's action on its substrate angiotensinogen

Aliskerin (TOPNOTCH)

30

releases nitric oxide(NO), relaxes smooth muscle, especially vascular, increases Cgmp (cyclic guanosine monophosphate); for cyanide poisoning

Amyl Nitrite (TOPNOTCH)