Viral escape

Question 1

alpha, beta and gamma herpesviruses

Answer 1

a: HSV1,2 and Herepes zoster (neurotropic with full latnecy)
beta: CMV HHV-6 HHV-7 (don’t have full latency- reactivation)
gamma: EBV and Karposis (true latency and oncogenesis)

Question 2

Where does Varicella virus zoster hide in latnecy?

Answer 2

dorsal root ganglion.

Question 3

How can CMV adn HSV inhibit MCH I expression?

Answer 3

snatches it away from route to surface, or by blocking the TAP transporter.

Question 4

what is the MHC I MCMV decoy bound by Ly49H NK cells?

Answer 4

m157.

Question 5

What is the MHC I decoy molecules in humans?

Answer 5

UL18, which will bbind the inhibitory LIR-1 on NK cells.

Question 6

What unusual immune responses generated with the cmv vaccine were protective in SIV?

Answer 6

HLA-E restricted, and CD8+ T cells restricted to the HLA II epitopes (fibroblast tropism).

Question 7

Viruses that show memory iinflation

Answer 7

CMV PARV4 (B19) EBV HIV HTLV-1

Question 8

Viruses induceing exhaustino

Answer 8

HIV, HCV, HBV and LCMV

Question 9

4 factors important for memory inflation?

Answer 9

Conventional proteasome (no need for immunoproteasme)
antigen persistence
costimulatio and CD4 T cell help.

Question 10

inflationary T cells for human adenovirus vectors?

Answer 10

Not so much of an inflationary response, but do have transcriptional overlap with CMV.

Tbet+ Eomes- pT cell phenoypte was enriched in those who resoled HCV vs chronic.

Question 11

What NK cells are expanded in inefction?

Answer 11

NKG2C, perphaps by UL40 stabilisation of HLA-e, the ligand for NKG2C.

Question 12

What intermediate population may maintain CD8+ Tem?

Answer 12

CX3CR1 itermediate peripheral memory cells.

Tcm (no CX3CR1)
Tem CX3CR1 high
Tem CX3CR1 null.

Question 13

Does adenovirus induce CX3CR1 populations?

Answer 13

yes in CD8+ antigen specific CD8s.