Viral GI Micro-Deebs Flashcards

1
Q

Cause of death from Norovirus?

A

DEHYDRATION

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2
Q

What 2 things does the stool of a person infected with viral Gastroenteritis NOT INCLUDE?

A

WBCs

Blood

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3
Q

Age group and time of year of Rotavirus?

A

Less than 5 years old (less than 2 is more severe)

Winter

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4
Q

Setting associated with Rotavirus?

A

School or daycare

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5
Q

Setting for Norovirus?

A

Common-source…linked to food or water
ALL PEOPLE GET SICK AT SAME TIME

CHIPOTLE!

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6
Q

Properties of Rotavirus?

A

RNA
Icosahedral capsid
Non-enveloped
DS segmented genome

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7
Q

Class of Rotavirus genome?

A

Class III

*thats kind of rare!

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8
Q

Tropism for Rotavirus?

A

Mature absorptive villous epithelium in upper 2/3 of small intestine

*confined to mucosa

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9
Q

What does Rotavirus have that is rare for a virus?

What does it do?

A

Toxin!

It acts on the epithelium to poke holes and electrolytes leak out…causing water to stay in the lumen

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10
Q

How long is someone infected with Rotavirus contagious?

A

2-5 days after diarrhea starts

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11
Q

Incubation period for Rotavirus?

A

2 days

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12
Q

What activates Rotavirus?

A

The digestive enzymes in the stomach! So once the viral particle has repilicated in the small intestine…the new virions are not directly toxic to the cells they encounter

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13
Q

What is ISVP?

A

Intermediate Sub-viral particle of Rotavirus…After it has been activated in the stomach and it is on its way to the Small intestine!

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14
Q

What Group of the VP6 element of Rotavirus infects humans?

A

Group A

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15
Q

How do you detect Rotavirus in an infected person?

A

RT-PCR
ELISA
Latex agglutination…

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16
Q

What is special about the packaging of Rotavirus?

A

It is double-packaged!!

17
Q

What component of Rotavirus pokes holes in epithelial cells to release the virus into the lumen?

A

NSP4

18
Q

How many infectious particles of Norovirus need to me ingested to be infected?

A

10

19
Q

Describe the properties of Norovirus

A

RNA
Icosahedral
Non-enveloped
+ssRNA

20
Q

Class of Norovirus genome?

A

Class IV

21
Q

What comes first with Norovirus, vomiting or diarrhea?

A

Vomiting

22
Q

How long is someone infectious with Norovirus?

A

2 weeks

23
Q

How long does it take for Norovirus to resolve?

A

48 hours

24
Q

Why is immunity to Norovirus short-lived?

A

High Mutation rates!

DRIFT

25
Q

How do you detect Norovirus in an infected patient?

A

RT-PCR

ELISA

26
Q

What serotypes of Adenovirus can cause gastroenteritis?

A

40-42

27
Q

Who does Adenovirus infect?

A

Infants, immunocompromised

28
Q

Properties of Adenovirus?

A

DNA
Icosahedral
Non-enveloped
DS Linear DNA

29
Q

What class is the genome of Adenovirus?

A

Class I

30
Q

Who gets the vaccine for Adenovirus?

What serotypes?

A

Military

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