Viral Hepatitis

Question 1

Enterically transmitted hepatitis viruses are

Answer 1

HAV and HEV

Question 2

Mode of transmission of HAV

Answer 2

Feco-oral

Question 3

Pathogenesis of HAV

Answer 3

Ingestion»replication in GIT&raquo_space; viremia&raquo_space; to liver
No CPE
Hepatocytes are attacked by CTL

Question 4

1st Ab to appear

Answer 4

IgM

Question 5

When does IgG appear in HAV?

Answer 5

Following the appearance of IgM by 1-3 weeks

It gives life-long immunity

Question 6

Risk group of HAV

Answer 6

Children and young adults

Question 7

Incubation period of HAV

Answer 7

2-4 weeks

Question 8

Diagnostic test of acute HAV

Answer 8

Anti-HAV IgM

If IgG is detected in the first few weeks»» prior infection or vaccination

Question 9

Post exposure prophylaxis of HAV

Answer 9

**<12 mths : IG

≥12 mths

• *12mths-40yrs “healthy” : 1 dose of vaccine
• *>40yrs “healthy” : 1 dose of vaccine + IG
• *Immunocompromised or chronic liver disease : 1 dose of vaccine + IG
• • If vaccine contraindicated : IG

IG dose : 0.1 ml / kg

Question 10

HEV incubation period

Answer 10

0.5 - 2 months

Question 11

Mode of transmission of HEV

Answer 11

Feco-oral

Question 12

HEV has high mortality rate in ……

Answer 12

Pregnant women

Question 13

There is no vaccine for …..&……

Answer 13

HEV & HCV