Viral Hepatitis 2 Flashcards
(21 cards)
Mode of transmission of HBV
Blood
Sexual
Perinatally
…….% of HBV patients become chronic
5-15%
Incubation period of HBV
1.5-6 months
Ig detected in window period of HBV
Anti-HbBc IgM
1st antigen of HBV to appear
HBsAg
High HBeAg indicates……
High infectivity
Active immunization of HBV
Recombinant HBV vaccine containing HBsAg produced in yeast
IM in 3 doses 0,1,6 months in deltoid region except neonates in anterolateral aspect of thigh
Indication of successful HBV vaccine
Anti HBsAb titre > 10 IU/ml
Ttt of HBV
Alpha interferon in chromic HBV infection
Antiviral drug-nucleotide analogue as “lamivudine”
Mode of transmission of HCV
Blood Organ transplant Perinatal Sexual Sharing personal items
Defective virus ….
HDV
HDV is dependant on ……
HBV
Incubation period of HCV
0.5-6 months
…….. % of HCV patients become chronic
75-85%
Seroconversion of HCV may take …….
6 months
-ve RT PCR of HCV indicates
No current infection
HCV antibodies …….
Doesn’t differentiate bet acute, chronic or resolved infection
Advantage of RT PCR in HCV
Diagnose early infection before seroconversion
Demonstrate active viral replication
Follow up ttt
Screening blood donors
ttt of HCV
1) combination of
Alpha interferon
Ribavirin
Sofosbuvir “Sovaldi” inhibits viral RNA polymerase and can be used without interferon
2) Harvoni combination of sfosbuvir and ledipasvir
Hepatitis C virus NS5A protein inhibitor
Monitor ttt of HCV by
Quantitative HCV viral load
After 4 weeks of ttt
At the end of ttt
At 12 weeks following completion of ttt
Duration of HCV ttt ……..
And depends on ……
12-24 weeks
1 genotype 2 viral count 3 presence of cirrhosis
