Viral Hepatitis

Question 1

What is hepatitis?

Answer 1

Inflammation of the liver caused by infectious or non infectious diseases

Question 2

What are the infectious dx that cause hepatitis?

Answer 2

Viral
Bacteria

Question 3

What are the non infectious dx that cause hepatitis?

Answer 3

Drugs
Toxins
Alcohol

Question 4

Hepatitis A belongs to which family?

Answer 4

Picornaviridae

Question 5

Hepatitis b belongs to which family?

Answer 5

Hepadnaviridae

Question 6

Hepatitis c belongs to which family?

Answer 6

Flaviviridae

Question 7

Hepatitis d belong to which family?

Answer 7

Deltaviridae

Question 8

Hepatitis E belongs to?

Answer 8

Hepeviridae or Caliciviridae

Question 9

Hepatitis G belongs to?

Answer 9

Flaviviridae

Question 10

What does HBV cause?

Answer 10

Polyartertis nodosa
Hepatocellular carcinoma

Question 11

Infection with HBV is identified by the presence of which antigen?

Answer 11

HBsAg

Question 12

There are 8 genotypes of HBV. Genotype A is found in?

Answer 12

India, Burundi

Question 13

Genotype B is found in?

Answer 13

China, East Asia

Question 14

Genotype C is found in?

Answer 14

China, Bangladesh

Question 15

Genotype D is found in?

Answer 15

Iran, Tunisia

Question 16

Genotype E is found in?

Answer 16

Senegal, Nigeria

Question 17

Genotype F is found in?

Answer 17

Columbia, Venezuela

Question 18

Genotype G is found in?

Answer 18

United States

Question 19

If mother is positive for HBsAg and HBeAg, what happens to the infants?

Answer 19

70-90% of infants infected.

90% become chronic carriers.

Question 20

If mother is positive for only HBsAg, what happens to infants?

Answer 20

<10% of infants infected.

90%become chronic carriers

Question 21

Avg incubation period for hepatitis B is?

Answer 21

120days.

Question 22

What are the serologic tests for HBV?

Answer 22

HBsAg test
Anti HBsAg
Anti Hbc

Question 23

What are the approved drugs for hbv?

Answer 23

Interferon alpha 2b
Lamivudine
Entecavir
Adefovir
Telbivudine
Tenofovir

Question 24

What is the epidemiology for Hcv?

Answer 24

200million infected globally

2.3 million people infected each year worldwide

Question 25

What is the mode of transmission of Hcv?

Answer 25

Blood born virus with low risk of sexual transmission. Transmission.. Nosocomial, genital mutilation, ritual sacrifice etc

Question 26

What are the risk factors for Hcv?

Answer 26

Injection drug abuse. Dental surgery Therapeutic injection Intravenous drug

Question 27

What is the pathogenesis of Hcv?

Answer 27

They have a predilection for hepatocytes. They reach the hepatocytes through the sinusoids. Complex interactions on the surface of hepatocytes leads to endocytosis of viral particle aided by clarthin. The rna is released into the cytoplasm. Replication is dependent on liver specific microRNA 122.

Question 28

What are the IPC measures for hepatitis treatment?

Answer 28

Vaccine for hav hbv and hev Treatment of acute cases of Hcv Avoid needle stick injury Safe blood transfusion by proper screening of blood Sterilisation of medical devices, equipment etc