Viral Hepatitis Flashcards
(24 cards)
Which two hep viruses are self limited?
HepA and E
Which Hep viruses have chronic hep?
Hep B, C, and D
Diagnostic serology for PBC?
Small bile ducts
Anti-mitochondrial antibody
Bile system characteristic for PSC?
PSC Correlated to what condition?
- Large bile ducts - BEADED
- IBD = usually also have PSC
HepA -family of virus?
picornaviridae
Food or water contaminated with HepA?
- food handlers
- raw shelfish
- travel to endemic areas
HepB virus - classification/family?
hepadnaviridae
Only hep virus that has DNA genome?
HepB
Most common race with HepB?
ASIANS!
THEN AFRICANS!
Treat HepB in an adult?
Nothing - observe for first 6mo bc 80% chance he/she will fight it off on their own w/out chronic disease
HBV chances of developing chronic hepatitis?
The younger you are the more risk. as you get older less risk
Immune tolerance and HepB
-What is it?
-seen in babies who get HepB - their immune system isnt ready to mount an attack yet so the virus runs rampant. Immune system not going yet means no destruction of HepB infected hepatocytes = no hepatitis
Only curative treatment for HepB?
Interferon! - cannot use in patients with cirrhosis
-the pills only stop continued liver damage but lifelong treatment
Why dont we use lamivudine anymore?
Resistance eventually brings back damage
Benefit to adofovir?
effective against lamivudine-resistant mutants
HepD
- what class/family?
- how does it inftect?
- delta
- needs HepB to replicate
Special thing about HepE?
causes fulminant hep failure in pregnant women
in other people wokrs just like HepA!
HepC virus family?
flavivirus
Interesting effect of HepC on the liver?
The liver enzymes can go up at certain times or down. So just because you check liver enzymes one day and they are low does not mean that they dont have the virus
HepC and ALT relationship:
No correlation! Can go up or down or be normal at times!
HepC and alcohol relationship:
Alcohol causes disease to progress MUCH FASTER!
End point of sustained virological response:
cant get rid of it but down to levels where it cant divide and do damage
not a cure
WHy pegilate the drug interferon?
basically adding a huge protein onto the drug = longer drug life
Best new medication for HepC
Harvoni!
