Viral Meningitis Flashcards Preview

Microbiology Exam 5 > Viral Meningitis > Flashcards

Flashcards in Viral Meningitis Deck (57):
1

is the brain the POE for viral infections?

NO

2

Why isn't viral meningitis as common as in the past?

vaccination against mumps

3

how does the severity of viral meningitis differ from bacterial

viral is usually benign with rapid resolutions to disease process with little to no sequelae

4

what are the most common viral agents in meningitis

ECHO and Cocksackie
HHV 6 and 7

5

what age group dies HHV 6 and 7 target

6 months to 2 years

6

what age group does Non-polio enterovirus affect

2 yo and older

7

what are the signs and symptoms of viral meningitis

irratibility
lethargy
fever
HA, Nuchal rigid, vomit, opisthotonos, eyeball pressure, and photophobia

8

what is the major cause of acute febrile illness in infants and young children

HHV 6 and 7

9

What infection cause children 6mo-12mo to many ER visits (20%)

HHV-6

10

what is the cause of many first time febrile seizures among ages <2yo

HHV 6 and 7

11

Primary HHV6/7 infection in children with functional immune system results in

asymptomatic infection
exanthem subitum/roseola infantum

12

With symptomatic or asymptomatic HH-6 causes what types of infections

latent persistent infection
Chronic persistent infection (salivary glad)

13

what are the manifestation of HHV 6 and 7 meningitis and how long does it last

high fever, lethargy, irritability, malaise, no rash until fever disappears then rash appears
usually lasts 4-6 days

14

Diagnosis of aseptic meningitis

spinal tap is aseptic

15

Treatment of aseptic meningitis

treat otherwise healthy infants supportively, if therapy is done depends on viral resistance and sensitivity

16

what is HSV 2 aseptic meningitis

patient has genital herpes, fever and aseptic meningitis

17

what type a virus is a LCM virus

arenavirus

18

?what is LCM virus resistant to

Drying- important for transmission

19

what is the the morphology of LCM virus

enveloped nucleocapsid containing RNA

20

how many arena virus infect humans

7

21

what are the most important arena viruses

LCM
lassa virus

22

which arena virus is passed by inhalation of infected rat urine and causes hemorrhagic fever in humans

Whitewater arroyo virus

23

what is important about animals who are LCM virus reservior

the have life long viremia and shed virus in feces and urine

24

what are the major animal reservoir for LCM virus

house mouse- primary
hamsters
other rodents

25

how does LCM virus spread from rodent to human

direct wit infected animal
inhalation of aerosols or dust with virus
food

26

when is the peak seasonality of LCM virus

winter- when rodents come inside house

27

what is the consequence of LCM viral disease in immunocomprimised

systemic infection and death

28

what is LCM virus pathogenesis

perivascular infiltration of meninges and all parts of the brain with macrophages and lympcytes

29

What is grippe

a flu-like illness of variable duration is the most common manifestation of LCM virus

30

What happens after defervescence of fever in LCM virus

a subacute meningitis with classic triad

31

what are the possible outcomes of prenatal LCM virus infection

1st/2nd trimester
spontaneous abortion, chorioretinitis, microcephaly, macrocephaly, hydrocephalus

32

what percentage of children have severe neurological sequelae in LCM virus

75%

33

how do you diagnose LCM virus

history of rodent contact, CSF+Fluorescent AB test, acute & convalescent sera,

34

what is the treatment for LCM virus

supportive can take up to 3 months

35

what is the prevention for LCM virus

rodent control

36

what are 4 types of non-polio enterovirus

1. ECHOvirus
2.Coxsackie
3. Entervius 68-71
4. HpeV 1-3

37

What is non-polio enterovirus common for

important viral pathogen causing febrile illness with or without rash

38

what ratio of febrile illness and young children during summer and fall months is non-polio enterovirus responsible for

1/2

39

what is the most common known cause of aseptic meningitis in countries that vaccinate against mumps

non-polio enterovirus

40

What is the transmission of non-polio enterovirus

fecal oral (water), inhalation, direct contact, hand to eye, in utero

41

what is the reservoir for non-polio enterovirus

humans are sole host
environment and humans can be reservoir

42

what is the gender relationship in non-polio enterovirus

males manifest with disease although equal m/f infected

43

what is the age relationship in non-polio enterovirus

both incidence and severity are inversely related with patient age
1yo highest attack rate, severe disease in older

44

what is the seasonality of non-polio enterovirus

temperate climate, peak in summer and fall months but sporadic can occur year round

45

what are RF for non-polio enterovirus

neonates, immunocompromised

46

what non-polio enterovirus can cause neonatal sepsis

ECHO virus

47

how is Neonatal sepsis transmitted

vertically

48

what is the POE of neonatal sepsis

POE to CNS via viremia

49

what are predisposing factors for neonatal sepsis

male, premature, maternal infection 2 weeks before birth

50

what is the acute febrile symptoms in non-polio enterovirus

fever, headache, malaise, +/-vomitting/diahhrea, +/- maculopapular rash

51

what can non-polio enterovirus acute febrile disease develop into

classic: fever + rash, HFMD, herpangia. pleurodynia, pharyngitis, conjunctivitis or severe: meningitis ,viremia, encephalitis,myocarditis, hepatitis

52

what are the age related signs of aspetic meningitis in non-polio enterovirus

young child- fever, irritability
older child- fever, headache, and nuchal rigidity
adult- fever, nuchal rigidity, and HA needing narcotics to manage

53

which specific non-polio enterovirus causes regional and world epidemics of undifferentiated febrile illness that sometimes progresses to encephalitis?

enterovirus 71

54

what are the 3 different encephalits syndoromes based n geographic location in non-polio enterovirus

acute flaccid paralysis (US, Europe, South America)
HFMD- meningoencephalitis (japan, China)
HFMD-encephalitis (Malaysia, Taiwan)

55

how do you diagnose non-polio enterovirus

PCR for enteroviral agents, Tissue culture (rare but gold standard), PMNs predominate early then shift to leukocytosis

56

what is the treatment for non-polio enterovirus

symptomatic
Pleconaril

57

What is the prevention of non-polio enterovirus

none