Virology 2

Question 1

replication in T cells, epithelial and endothelial cells

Answer 1

VZV

Question 2

difference between latency of VZV and HSV?

Answer 2

VZV has several gene products that are actively transcribed and translated in latently infected neurons

Question 3

blisters: disease, virus, contraindication

Answer 3

chickenpox, VZV, aspirin

Question 4

vaccine for VZV

Answer 4

live, attenuated Oka strain

Question 5

CMV: what kind of virus is it?

Answer 5

beta-herpesvirus

Question 6

herpesvirus that targets macrophages

Answer 6

CMV

Question 7

herpesvirus with latency in monocyte and monocyte progenitors

Answer 7

CMV

Question 8

inclusion body disease; owl’s eyes

Answer 8

CMV

Question 9

congenital defects: deafness, mental retardation

Answer 9

CMV

Question 10

size of CMV genome

Answer 10

230 kbp

Question 11

CMV: enters nucleus?

Answer 11

yes

Question 12

daycares

Answer 12

CMV

Question 13

heterophile antibody negative

Answer 13

CMV

Question 14

CMV treatment

Answer 14

ganciclovir, foscarnet, cidofovir (NOT acyclovir)

Question 15

children: high fever for 4 days, followed by a rash after fever breaks

Answer 15

HHV-6

Question 16

herpesvirus that replicates in CD4 T cells

Answer 16

HHV-6

Question 17

Epstein Barr virus is what kind of virus?

Answer 17

gamma-herpesvirus

Question 18

herpes that replicates in B cells/epithelial cells

Answer 18

EBV

Question 19

herpes latent in memory B cells

Answer 19

EBV

Question 20

stimulate and immortalize B cells

Answer 20

EBV

Question 21

herpesvirus limited to epithelia of pharynx and B cells

Answer 21

EBV

Question 22

EBV latency III: happens where, causes what?

Answer 22

proliferating B cells; infectious mononucleosis and PTLD

Question 23

EBV latency I/II: happens where, causes what?

Answer 23

memory B cells; cancer

Question 24

atypical T or Downey cells

Answer 24

EBV

Question 25

role of atypical T or Downey cells in EBV

Answer 25

kill Lat III infected cells

Question 26

what causes mononucleosis in EBV?

Answer 26

rapid proliferation of atypical T cells (Downey)

Question 27

exudative pharyngitis, splenomegaly

Answer 27

EBV-mediated mononucleosis

Question 28

EBV-mediated mononucleosis: symptoms are due to what?

Answer 28

T cell response

Question 29

heterophile antibody positive

Answer 29

EBV-mediated mononucleosis

Question 30

what is PTLD?

Answer 30

EBV-mediated B cell proliferative disease

Question 31

large T-antigen

Answer 31

polyomavirus

Question 32

importance of helicase in large T antigen of polyomaviruses

Answer 32

binds and disrupts p53

Question 33

BK polyoma virus: what diseases?

Answer 33

nephropathy, BMT-hemorrhagic cystitis

Question 34

JC polyoma virus: what diseases?

Answer 34

progressive multifocal leukoencephalopathy

Question 35

progressive multifocal leukoencephalopathy

Answer 35

JC polyoma virus

Question 36

nephropathy, BMT-hemorrhagic cystitis

Answer 36

BK polyoma virus

Question 37

Merkel cell carcinoma is caused by?

Answer 37

clonal integration into host chromosome; oncoprotein expression

Question 38

stiff neck

Answer 38

enterovirus

Question 39

infants: hard to awaken, poor eating

Answer 39

enterovirus

Question 40

norovirus is what kind of virus?

Answer 40

calicivirus