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Block 3 Immuno > Virology > Flashcards

Virology Flashcards

(62 cards)

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1
Q

bronchiolitis

A

RSV

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2
Q

Polio/picornavirus: enters nucleus?

A

no

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3
Q

penton spikes

A

adenovirus

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4
Q

viral “surfing”

A

adenovirus

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5
Q

adenovirus: enters nucleus?

A

yes

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6
Q

adenovirus vs. picornavirus: which has introns?

A

adenovirus

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7
Q

E7, E6, E2, VPL’s as vaccines

A

papillomavirus

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8
Q

what is the role of E7 in papillomavirus pathogenesis?

A

binds Rb, so that it gets degraded in proteasome

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9
Q

what is the role of E6 in papillomavirus pathogenesis?

A

recruits ubiquitin ligase and targets p53 for degradation, induces telomerase –> immortality

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10
Q

what does integration of viral genome cause in papillomavirus pathogenesis?

A

oncogenesis; disruption of E2 and allows for increased levels of E6 and E7 expression

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11
Q

vaccine for papillomavirus

A

capsid protein L1 self-assembles into VPLs –> protective, humoral immunity

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12
Q

influenza: viremia?

A

no

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13
Q

influenza: enters nucleus?

A

yes

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14
Q

bats and camels as host

A

MERS-CoV

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15
Q

paramyxoviridae: enters nucleus?

A

no

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16
Q

RSV: enters nucleus?

A

no

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17
Q

RSV: viremia?

A

no

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18
Q

what kind of T cell response do you get in infants after RSV infection?

A

Th2 –> wheezing

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19
Q

what kind of T cell response do you get in adults after RSV infection?

A

Th1 –> clearance

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20
Q

adenovirus: viremia?

A

yes

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21
Q

measles, mumps, rubella: viremia?

A

yes, before infecting target organ

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22
Q

what kind of vaccine is MMR?

A

live attenuated

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23
Q

Koplik spots

A

measles

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24
Q

what kind of virus is the measles virus?

A

paramyxovirus

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25
parotitis (inflammation of salivary glands)
mumps
26
what kind of virus is the rubella virus?
togavirus
27
congenital defects including: cataracts/ocular defects, mortality within first year, mental retardation
rubella
28
parvovirus B19: enters nucleus?
yes
29
parvovirus B19 infects what cells?
actively replicating RBC progenitors in bone marrow
30
parvovirus B19: what is the requirement for the virus to infect a cell?
cell must be in S phase
31
bright red cheeks, maculopapular rash
parvovirus B19
32
can cause anemia, fatal aplastic crisis
parvovirus B19
33
congenital defects: generalized edema, anemia, CHF
parvovirus B19
34
what kind of virus is a rotavirus?
reovirus
35
most common cause of severe diarrheal illness in infants and young children
rotavirus
36
mechanism for rotavirus-mediated diarrhea
NSP4 acts as enterotoxin: - causes increased intracellular Ca2+ concentration - disrupts tight junctions - signaling via phospholipase C - directly acts on crypt cells - stimulate enteric nervous system --> increase Cl- secretion
37
concern: vaccine-related intussusception
rotavirus
38
#1 cause of foodborne illness outbreaks
norovirus
39
enterovirus (coxsackie virus): viremia?
yes
40
stiff neck
enterovirus
41
herpangina (mouth blisters)
coxsackie virus
42
hand, foot, and mouth disease (vesicular lesions, sore throat, loss of appetite)
coxsackie virus and enterovirus 71
43
systemic childhood viruses
Mike Ripped Everyone's Pants: measles/mumps, rubella, enterovirus, parvovirus B19
44
fever, hemorrhage, acute renal failure
hantavirus
45
sin nombre virus
hantavirus
46
host: deer mouse
hantavirus
47
hantavirus host
deer mouse
48
arboviruses (2)
west nile and dengue
49
if >50 years old, unexplained encephalitis/meningitis in late summer/fall, suspect:
west nile fever
50
breakbone fever, muscle/"bone" pain, joint pain
dengue shock syndrome, dengue hemorrhagic fever
51
when does dengue shock syndrome, dengue hemorrhagic fever occur?
when individual with antibodies to one serotype is infected with another serotype
52
positive tourniquet test to test capillary fragility
dengue shock syndrome, dengue hemorrhagic fever
53
rupture of vasculature, internal bleeding, shock
dengue shock syndrome, dengue hemorrhagic fever
54
African squirrels --> African rats --> prairie dogs --> pet owners
monkeypox
55
muscle ache, backache, rash (raised bumps filled with fluid that crusts and scabs off)
monkeypox
56
herpes: enters nucleus?
yes
57
tegument
herpesvirus
58
members of alpha subfamily of herpesviruses
HSV-1, HSV-2, VZV
59
where is the latency for alpha subfamily of herpesviruses
sensory ganglia
60
latency-associated transcripts (LATs) that repress viral gene expression
HSV-1 and HSV-2
61
treatment for HSV-1 and HSV-2
acyclovir
62
herpes whitlow
hand dermatitis

Block 3 Immuno (2 decks)

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