Virology Flashcards
(45 cards)
all known viruses with a helical structure have
RNA genomes
Most helical viruses possess
An outer envelope
Adenoviruses are what shape?
Icosahedral and non-enveloped
What’s an example of a enveloped cubic virus?
Herpesviridae
What’s an example of a enveloped tubular virus?
Influenza
Vast majority of viruses have what type of genome
RNA
What are the 6 DNA viruses?
1 - herpes 2- Hep B 3- Parvovirus b 4- Adeno 5- HPV 6- Polyoma
Most neutralizing Abs target what part of the virus?
Often attachment proteins- surface
Where does the DNA virus replicate its DNA?
In host cell nucleus - mediated by viral enzymes
The “+” strand of RNA virsues
Codes for proteins directly - like mRNA
The “-“ strand of RNA viruses
needs to make a “+” strand like influenza
Enveloped viruses enter cells via….
Non-enveloped viruses enter via
Fusion
Endocytosis
Outcome of a viral infection depends on 2 things
1- host’s defence mechanisms
2- Organism’s ability to evade destruction
An example of a slow virus infection
measles
example of chronic carriers (virus)
CMV, Rubella, Hep B HepC
What are 2 good disinfectants for viruses
Hypochlorite and gluteraldehyde
viruses resistant to phenols
What type of viruses have hours to 1-2 day incubation periods
GI viruses
Respiratory viruses
What type of viruses have week long incubations (1-3 weeks)
MMR VSV, HSV, Chlamydia Enteroviruses, Polio WNV
4 viruses that take weeks to months to incubat
HIV
EBV
Rabies
Hepatitis virsues - B
How long after infection is IgM formed?
1 week persists for 4-6 weeks - up to 6 mo
IgG persists for how long?
months to years
Delayed hypersensitivity T cells release
macrophage activating factor
Il-1 and IL-2 modulate
the immune response against a virus
Detect viruses in 3 ways
cytopathic effect
serology - detect antigen
EM
