Virology (hepatitis viruses) Flashcards Preview

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Flashcards in Virology (hepatitis viruses) Deck (17):
1

What are signs and symptoms of all hepatitis viruses

episode of fever, jaundice and increase in ALT and AST.

2

HAV

Asymptomatic, acute, alone

  • Virus
  • Transmission
  • carrier
  • incubation
  • HCC risk

  • RNA picornavirus
  • fecal oral
  • no
  • short
  • no

3

HBV

  • Virus
  • Transmission
  • carrier
  • incubation
  • HCC risk

  • DNA, hepadnavirus
  • parental, sexual, maternal
  • Yes
  • Long (months)
  • Yes, it integrates into the host genome, acts like an oncogene.

4

HCV

  • Virus
  • Transmission
  • carrier
  • incubation
  • HCC risk
  • 4 C's

  • RNA flavivrius
  • Primarly blood (IVDU, post transfusion)
  • Yes
  • Long
  • Yes, chronic inflammation
  • Chronic, cirrhosis, carcinoma, carrier

5

HDV

  • Virus
  • Transmission
  • carrier
  • incubation
  • HCC risk
  • Notes

  • RNA, Delta virus
  • Parental, sexual, maternal
  • Yes
  • Incuabtion
    • Superinfection (get HBV then you get HDV)
    • Co-infection (get HBV with HDV)
  • No
  • Defective virus dependent on HBV --> superinfection dec prognosis

6

HEV

  • Virus
  • Transmission
  • carrier
  • incubation
  • HCC risk
  • Notes

  • RNA hepevirus
  • fecal oral
  • No
  • Short
  • No
  • High mortality in pregnant women, Enteric, Expectant mothers, epidemic

7

In HBV, the DNA polymerase has both DNA and RNA depedent activities.

Describe the Entry, Host RNA polymerase, and DNA polymerase functions.

  • Entry
    • Upon entry into the nucleus, the polyerase functions to complete the partial dsDNA
  • Host RNA polymerase
    • transcribes the mRNA from the viral DNA to make the viral proteins
  • DNA polymerase
    • reverse transcribes the viral RNA to DNA (which helps form new viral particles).

8

What is best used to detect active hepatitis A.

Anti-HAV (IgM)

IgM antibody to HAV

9

What protects against reinfections? 

Anti-HAV (igG), 

IgG antibody indicates prior HAV infection and or prior vaccination

10

what indicates HBV infection

HBsAg

Antigen found on surface of HBv

11

What indicates immunity to HBV?

Anti-HBs

Antibody to HBsAg

12

What is the antigen associated with the core of HBV

HBcAg

13

What is the antibody to HBcAg during

  • acute/recent infection
  • prior exposure or chronic infection
  • This antibody is positive during what?

  • IgM
  • IgG
  • Positive during the window period

14

  • What is a second different antigenic determinant in the HBV core 
  • what does it indicate

 

  • HBeAg
  • Indicates active viral replication adn therefore high transmissibility

15

What indicates low transmissibility?

Anti-HBe

16

  • In viral hepatitis ALT to AST ratio
  • In alcoholic hepatitis ALT to AST ratio

  • viral hepatitis= ALT>AST
  • Alcoholic hepatitis= AST>ALT

17

Important diagnostic tests

  • Incubation period
  • Prodrome, acute disease
  • Convalescence
    • Early 
    • Late

  • Incubation period = HBsAg
  • Prodrome, acute disease = HBsAg (Anti-HBc)
  • Convalescence
    • Early = Anti-HBc
    • Late = Anti-HBc, Anti-HBs