Virulence in bacteria Flashcards Preview

RUSVM PID Exam#1 (Orange semester Fall 2016) > Virulence in bacteria > Flashcards

Flashcards in Virulence in bacteria Deck (69)
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1

symbiosis that is beneficial to both organisms involved., relation is positive for both organisms

Mutualism

2

is a class of relationships between two organisms where one organism benefits from the other without affecting it. Good for one, no problem for the other (most intestinal flora)

Commensalism

3

non-mutual symbiotic relationship between species, where one species, the parasite, benefits at the expense of the other, the host. One takes advantage of the other

Parasitism

4

Invasion and multiplication of micro-organisms

Infection

5

Causes structural and functional damage

Disease

6

E. Coli O157: H7 use this type of motility along with H-antigens, Listeria mnocytogenes (Not in all bacteria, mainly in gram - bacteria)

Flagella

7

Flagella is composed of?

Flagellin

8

Pili+fimbriae (which are the same thing) came together to be known as ?

Fibrillae

9

Used mainly for adhesion by F-antigens

Pili

10

Bacterial conjugation use this for plasmid transfer

Special pili known as sex pili

11

parasites are capable of living and reproducing either inside or outside cells. ( cause Cell lysis)

Facultative intracellular

12

cannot reproduce outside their host cell, meaning that the parasite's reproduction is entirely reliant on intracellular resources. (cause Cell lysis)

Obligate intracellular

13

Extracellular _________ -attach to the heart, parasites take over local use of nutrients oxygen

thrombosis

14

Extracellular immunological reaction is when?

macrophages and neutrophils produce oxygen radicals/ enzymes to kill the host cell

15

During invasion, what virulence factors are involved?

-Capsule
- need to haveProteins that circumvent innate immunity or they will be killed off
-Iron uptake for growth (body hides iron from bacteria) bacteria have to counteract that to have iron for own metabolism
-Production of extracellular enzyme like
a. Hyaluronidases
b. Collagenases
c. Fibrinolysins
d. Coagulases
e. Hemolysins
f. Leucocidins

16

-Not in all bacteria
-composed of Polysaccarides-proteins
- is a Virulence factor
a. colonization
b. invasion
c. Adhesion
d. Protection against phagocytosis and complement
-Environmental protection (spore formation)
-K antigens of the cell

Capsule

17

Bacterial metabolites like Clostridium, high molecular weight-->vaccination (thus antigenic)

Type I, II, III

Exotoxins

18

chemically treated (formalin) toxin

toxic effect goes down, antigenicity +vacination goes up

Anatoxins

19

is the capacity of a chemical structure (either an antigen or Hapten) to bind specifically with a group of certain products that have adaptive immunity: T cell receptors or antibodies (a.k.a. B cell receptors).

Antigenicity

20

Type of exotoxin that binds receptor, disturbance of cell metabolism.
Examples: STa ETEC, clostridium perfringens, Staphylococco, Streptococci

Type 1 exotoxin

21

type of exotoxin where there is cell wall damage. staphylococcus aureus (alfa toxin-hemolysis), Actinobacillus pleuropneumoniae (pore forming)-makes holes in cell through cell lysis

Type II exotoxin

22

Type of exotoxin that is intracellular toxins, A component goes intracellular (IC), B (binding) component binds membrane

Type III exotoxin

23

Examples of Type III exotoxin

-Heat labile toxin
-Shiga toxin
-Botulinum toxin
-tetanospasmin

24

Part of the cell wall in Gram +/- bacteria

Endotoxin (part of the cell wall)

25

Toxin that targets cell wall components and causes lots of damage and causes an immune reaction. LPS (heat stable) Causes fever, general sickness, tissue damage, cardiovascular shock, death

Endotoxin for Gram negative

26

Function of the lipopolysaccharide?

Protection against toxic products and complement activation. Acts as an endotoxin for infections with a gram negative bacterium

Endotoxin lipopolysaccharide is released by multiplication of membrane vesicles or they are released by "lysing" to get endotoxine release

27

Gram negative bacteria-->lipid A =Endotoxin----> ?

Endotoxic shock

28

Complement activation causes?

Anaphylatoxin Chemotaxis

29

Hageman factor causes?

Intravascular coagulation

30

Macrophages-------> ?

Cytokines