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Viruses Flashcards

(106 cards)

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1
Q

Hep B family and features

A

Hepadnavirus

DNA virus that is envloped

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2
Q

Env gene products

A
  • gp120
  • gp41
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3
Q

CMV Dx:

A

Owl-eye inclusion in biopsy material and urine

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4
Q

Parvovirus major family of

A

B19

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5
Q

Treatment of suspected Rabies

A
  1. Postexposure prophylaxis
  2. One dose of human Rabies Ig
  3. Five dose of rabies vaccine (day 3, 7, 14, 28)
  4. Killed virus vaccine
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6
Q

Mumps symptoms and complications

A

Symptoms

Bilateral parotitis with fever, headache, and malasie

Complications

Pancreatitis, orchitis, and meningoencephalititis

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7
Q

Only DNA virus NOT ds

A

Parvo

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8
Q

HIV capsid protein

A

p24

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9
Q

Hep D family and features

A

No family

Circular RNA in envelope

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10
Q

Peak incidence of Picornaviridae

A

Summer/fall

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11
Q

HIV core nucleocapsid protein

A

p7p9

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12
Q

Major viruses of Pox family

A
  1. Variola
  2. Vaccinia
  3. Molluscum contagiosum
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13
Q

Kaposi sarcoma caused by

A

AIDs pts with HHV-8

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14
Q

EBV Target cell and receptor

A

B lymphocytes

CD21=CR2

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15
Q

Hep B disease presentation

A

Acute, occasionally severe

Chronic

Primary hepatocellular carcinoma, cirrhosis

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16
Q

Rabies is what family of viruses

A

Rhabdovirus

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17
Q

Hemagglutinin is

A

Surface glycoproteins that bind to sialic acid receptors

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18
Q

Negative sense RNA

A

Template strand

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19
Q

Reovirus transmission and disease

A
  1. Fecal-oral/respiratory
  2. Common cold, gastroenteritits
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20
Q

B19 pathogenesis

A

Infects erythroid progenitor cells resulting in cell lysis causing Anemia only significant to pts with Sickle cell

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21
Q

School-aged child to adult

Acute viral gastroenteritis (noninflammatory)

Cruise ship

A

Norwalk

Calicivirdae

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22
Q

Meningoencephalitis due to HSV

A

Fever, headache, confusion

Focal temporal lesion

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23
Q

Plantar warts due to HPV are what serotype

A

1

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24
Q

Rubella disease

A

German measles

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25
Positive sense RNA
Coding strand
26
Congenital Rubella syndrome symptoms
1. PDA 2. Pulmonary stenosis 3. Cataracts 4. Microcephaly 5. Deafness
27
ss(-)RNA viruses carry
RNA-dependent RNA polymerase
28
Hep A family and features
Picornavirus RNA virus in Naked Capsid
29
Koplik spots are
Seen in measles Maculopapular rash from the ears down =\> **giant cell pneumonia**
30
Coxsackie A diseases
1. Hand, foot and mouth 2. Herpangina 3. Aseptic meningitis 4. Acute lymphoglandular pharyngitis 5. Common cold
31
German measles symptoms
Erythematous rash begins on face and progresses to torso
32
1. Young adult with ARD 2. Swimmers and shipyard workers with **nonpurulent** conjunctivitis 3. Daycare: viral gastroenteritis
Adenovirus
33
Which DNA virus has virion-associated polymerase
Hepadnavirus Poxvirus
34
Pain Results From Our Bunions Always
ss(-)RNA viruses 1. **P**aramyxovirus 2. **R**habdovirus 3. **F**ilovirus 4. **O**rthomyxovirus 5. **B**unyavirus 6. **A**renavirus
35
Hep C family and featuers
Flavivirus RNA virus in Envelope
36
1. Young adults (wrestling, swim team) 2. Umbilicated warts 3. Eosinophilic cytoplasmic inclusion bodies
Molluscum contagiosum ## Footnote **Poxviridae**
37
VZV latent in
Dorsal Root Ganglia
38
EBV malignancies
1. Burkitt lymphoma (**c-myc oncogene**) 2. Nasopharyngeal carcinoma (**Asia**) 3. Hodgkin lymphoma
39
1. Synchronous rash begins in mouth and spreads to face and body 2. Guarnieri bodies (intracytoplasmic inclusions)
Variola/smallpox ## Footnote **Poxviridae**
40
Roseola cuased by
HHV-6
41
Paramyxovirus viruses
1. Mumps 2. Measles 3. RSV 4. Parainfluenza
42
Rabies virus binds to
Nicotinic Acetylcholine receptors
43
What is used to DX HSV?
**Tzank** **smear** to show the formation of multinucleated giant cells and **Cowdry type A** intranuclear inclusion
44
Flavivirus viruses
1. Yellow fever 2. Dengue 3. St. Louis encephalitis 4. Hep C 5. West Nile Virus
45
**Cal**l **He**nry **Pico** **Fl**o **To** **Co**me **R**ightaway
Positive Sense Viruses 1. **Cal**ici virus 2. **He**pevirus 3. **Pico**rna 4. **Fl**avivirus 5. **To**govirus 6. **Co**rona virus 7. **R**etro virus
46
Only DNA virus not Icosahedral
Pox: brick-shaped
47
1. Heterophile-negative mononucleosis in children and adults 2. Neonate with Jaundice, hepatosplenomegaly, thrombocytic purpura 3. Owl-eye intranuclear inclusion bodies
CMV
48
Ebola is what type of virus
Filovirus
49
HIV target cell and receptor
Th cells, Macrophages, Microglia CD4 plus CCR5 or CXCR4
50
CMV latency in
Mononuclear cells
51
Rhinovirus target cell and receptor
Resp epithelial cells ICAM-1
52
Fusion proteins action
destabilizes host membrane
53
Phenotypic mixing
When related viruses coinfect cell then the resulting proteins on the surface are a mixture capsid of the two viruses Internal NA remains the same
54
Hepevirus viruses
Hep E
55
Most +ssRNA viruses intermediate Replicative form
-ssRNA
56
Downey cells
Atypical reactive T cells due to EBV latency in B cells
57
Measles virus distinguishing characteristics
Hemagglutinin glycoprotein and fusion protein **No neuraminidase**
58
Rotavirus transmission and disease
Fecal-oral Gastroenteritis with no blood or pus
59
Only dsRNA virus
Reovirus
60
CMV disease
1. Cytomegalic inclusion disease 2. Mononucleosis 3. Interstitial pneumonitis 4. CMV retinitis
61
Hep E family and features
Hepevirus RNA virus in Naked capsid
62
+RNA virus mRNA transcribed from
-RNA made
63
Antigenic drift
1. Influenza A and B 2. **Slight** **changes** in antigenicity due to **mutation** in **H** and/or **N** 3. Causes **epidemics**
64
B19 disease in fetus
1. Sever anemia 2. Congestive heart failure 3. Hydrop fetalis 4. Spontaneous abortion
65
B19 disease in children/adults
1. Fifth diesase causing Erythema infectiosum, **slapped cheek fever** 2. Flu-like symptoms with facial rash
66
Togovirus viruses
1. Rubella 2. WEE, EEE 3. Venezuelan encephalitis
67
Polyomaviridae viruses
BK (Renal disease in AIDs) JC (PML in AIDs)
68
HIV matrix protein
p17
69
HSV is latent in
Trigeminal ganglion
70
Measles virus pathogenesis
Ability to cause cell:cell fusion leading to giant cells Viruses can escape immune detection
71
PEE Co Rn A Viruses
Picornaviruses * **P**olio * **E**ntero * **E**cho * **C**oxsackie * **R**hino * **A** Hep
72
Which Hep is transmitted fecal-oral
Hep A and Hep E
73
**Par**don **PaP**a **A**s **He** **H**as **Pox**
DNA virus 1. **Par**vo virus (Naked) 2. **Pa**pilloma (Naked) 3. **P**olyoma (Naked) 4. **A**denovirus (Naked) 5. **He**padna (Envoloped) 6. **H**erpes (Envoloped) 7. **Pox** (Envoloped)
74
Neuraminidase is
clips off sialic acid thus aiding in release of virus
75
Reoviridae viruses
1. Reovirus 2. Rotavirus 3. Colorado Tick Fever Virus
76
Rabies target cell and receptor
Neurons Ach receptors
77
Pharyngoconjunctivitis chx
Swimming pool conjunctivitis, **pink eye** Fever, sore throat, coryza and red eye **NONPURULENT**
78
Calicivirus viruses
Norwalk Noro-like virus
79
Only DNA virus that doesn't replicate in nucleus
Pox
80
1. Young adult with fever, lymphadenopathy, splenomegaly 2. Downey type 2 atypical T lymphocytes 3. Heterophile (**monospot**) postive
EBV
81
Polio pathogenesis
Virust targets **anterior horn motor neurons**
82
Antigenic shift
1. ***Influenza A only*** 2. Genetic **reassortment** 3. **Coinfection** with 2 different strains of Influenza A with reasortment of **segments** of genome 4. Produce **new** **agent** 5. **Pandemics**
83
Only naked RNA viruses
1. Picornavirus 2. Calicivirus 3. Hepevirus 4. Reovirus
84
Genital HSV latent in
Sacral Nerve Ganglia
85
Virion-associated polymerase carried by
1. Reovirus 2. Arenavirus 3. Retrovirus
86
Cytomegalic inclusion disease
1. Jaundice 2. Hepatosplenomegaly 3. thrombocytic purpura (**Blueberry muffin baby**) 4. Penumonitis 5. CNS damage
87
Hep A disease presentation
Mild acute No chronic No sequellae
88
Rabies symptoms
1. Flu-like 2. **Hydrophobia** 3. Seizures 4. Disorientation 5. **Hallucination** 6. **Coma** 7. Death
89
Arboviruses are
1. Togavirus encephalitis 2. Flavivirus 3. Bunyavirus
90
EBV diseases
1. Heterophile-positive mononucleosis, "**kissing disease**" 2. Lymphoproliferative disease 3. Hary oral leukoplakia
91
What is found in DX of HPV
Koilocytic cells (cells with perinuclear cytoplasmic vacuolization)
92
Negri bodies found in
Rabies
93
ROBA
Segmented RNA viruses * **R**eovirus * **O**rthomyxovirus * **B**unyavirus * **A**renavirus
94
Common warts due to HPV are what serotypes
2 and 4
95
Pol gene products
1. Reverse transcriptase 2. Integrase 3. Protease
96
Hep B intermediate replicative form
ssRNA
97
In +RNA retrovirus mRNA transcribed from
dsDNA intermediate
98
Herpesviridae viruses
1. HSV 2. VZV 3. EBV 4. CMV 5. HHV-6 6. HHV-8
99
Herpesviridae features
Intranuclear inclusion bodies Establishes latency
100
Adenovirus diseases
1. ARD and pneumonia 2. Pharyngoconjunctivitis 3. Epidemic Keratoconjunctivitis 4. Acute hemorrhagic cystitis 5. Gastroenteritis
101
Mumps distinguishing characteristics
Single Hemagglutinin Neuraminidase glycoprotein and Fusion protein
102
Adenovirus pathogenesis
Penton fibers act as **hemagglutinin**
103
Gag gene products
* Group-specifc antigens * p24 * p7p9 * p17
104
Measles presentation
**3 C's** 1. **C**ough 2. **C**oryza 3. **C**onjunctivitis
105
Hep C disease presentation
Acute is usually subclinical Most chronic Primary hepatocellular carcinoma, cirrhosis
106
Coxsackie B disease
1. **Bornholm** **disease** (*Devils Grip*) 2. Aseptic meningitis 3. Severe sytemic disease of newborn 4. **Myocarditis**

Microbology (6 decks)

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