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TCM Agents > Viruses > Flashcards

Viruses Flashcards

1
Q

Influenza

A

Orthomyxo -ssRNA Yes viral RNA-dependent RNA polymerase Envelope with surface hemagglutinin (H) and neuraminidase (N), type A has an animal reservoir (pandemic), antigenic drift/shift Respiratory disease, fever, muscle and joint pain Neuraminidase inhibitor

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2
Q

Human metapneumovirus

A

Paramyxoviruses -ssRNA yes Single surface HN glycoprotein Giant cells (syncytia) via cell fusing factor Common cold, pneumonia, bronchiolitis Supportive care

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3
Q

Parainfluenza

A

Paramyxoviruses -ssRNA yes Single surface HN glycoprotein Giant cells (syncytia) via cell fusing factor flu like respiratory, croup (seal barking cough), steeple sign (swelling in trachea) Supportive care

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4
Q

Respiratory syncytial virus

A

Paramyxoviruses -ssRNA yes Single surface HN glycoprotein Giant cells (syncytia) via cell fusing factor Infects ciliated epithelia cells, #1 cause pneumonia in

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5
Q

Mumps virus

A

Paramyxoviruses -ssRNA yes Single surface HN glycoprotein Giant cells (syncytia) via cell fusing factor, enters via pharynx or conjunctiva Painful enlargement of the salivary glands, epididymo-orchitis MMR live vaccine

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6
Q

Measles (Rubeola)

A

Paramyxoviruses -ssRNA yes Single surface HN glycoprotein Giant cells (syncytia) via cell fusing factor (Warthin-Finkeldey cells) Koplik spots (oral mucosa), inclusion body encephalitis, chronic subacute sclerosing panencephalitis MMR live vaccine, 93.3%

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7
Q

Hepatitis A

A

Picornaviridae +ssRNA no Fecal-oral transmission High occurrence in areas with poor sanitation (Asia and Africa) Abrupt onset with chronic state in immunocompromised Hep A vaccine

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8
Q

Hepatitis B

A

Hepadnaviridae dsDNA yes Parenteral, sex Dane particle (oncogenic transforming virus) Insidious onset, hepatocellular carcinoma Hep B vaccine

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9
Q

Hepatitis C

A

Flaviviridae +ssRNA yes Parenteral, sex Can be a carrier Insidious onset, hepatocellular carcinoma Supportive

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10
Q

Hepatitis D

A

Virion -ssRNA Hep B Parenteral, sex Requires hepatitis B first Abrupt onset with superinfection Supportive

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11
Q

Hepatitis E

A

Herpesviridae +ssRNA no Fecal-oral transmission High occurrence in areas with poor sanitation (Asia and Africa) Abrupt onset with chronic state in immunocompromised Supportive

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12
Q

oncornavirus (HTLV 1 HTLV 2)

A

Retrovirus +ssRNA yes Reverse transcriptase T-cell leukemia/lymphoma HTLV myelopathy/tropical spastic paraparesis and T cell lymphoproliferative in HTLV-II

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13
Q

Lentivirus (HIV 1, HIV 2)

A

Retrovirus +ssRNA yes Reverse transcriptase Multinucleated cells, attach via CD4 and CCR5/CXCR4, use western blot. Know: P24, P17, integrase, gp120 (binds CD4), gp41, nef (decreased CD4 and MHC-I expression) Lymphadenopathy, fever, weight loss, malaise. HIV-2 in W. Africa only Antiretroviral

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14
Q

HHV 1

A

Herpes dsDNA yes Acidophilic intranuclear inclusions (Cowdry) Capable of latency, neurotropic, multinucleated giant cells Herpes simplex 1 (HSV-1), transmitted by saliva, cold sores Acyclovir

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15
Q

HHV 2

A

Herpes dsDNA yes Acidophilic intranuclear inclusions (Cowdry) Capable of latency, neurotropic, multinucleated giant cells Herpes simplex 2 (HSV-2), genital herpes Acyclovir

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16
Q

HHV 3

A

Herpes dsDNA yes Acidophilic intranuclear inclusions (Cowdry) Capable of latency, neurotropic, multinucleated giant cells Varicella-Zoster (chickenpox), transmitted via saliva, Shingles (sensory nerves of the dorsal root ganglia) Acyclovir, VAR, Zoster vaccine

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17
Q

HHV 4

A

Herpes dsDNA yes Acidophilic intranuclear inclusions (Cowdry) Attach via CD21 on B cells, heterophile antibodies (monospot) Epstein-Barr virus, atypical activated T-cells (Downey), Hodgkin and Burkitt lymphomas Supportive

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18
Q

HHV 5

A

Herpes dsDNA yes Acidophilic intranuclear inclusions (Cowdry) Owl-eye basophilic intranuclear inclusion, transplacental, neonatal, perinatal (breast milk), saliva Cytomegalovirus, CMV mononucleosis-syndrome (tired, fever), atypical activated T Ganciclovir

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19
Q

HHV 8

A

Herpes dsDNA yes Acidophilic intranuclear inclusions (Cowdry) Kaposi Sarcoma-associated herpesvirus

20
Q

Smallpox

A

Poxviridae dsDNA yes Replicate in cytoplasm of host cell DNA-dependent RNA polymerase Respiratory transmission Smallpox vaccine

21
Q

Molluscum contagiosum

A

Poxviridae dsDNA yes Replicate in cytoplasm of host cell Direct contact nodules on face/trunk

22
Q

Human Papilloma Virus

A

Papillomaviridae dsDNA no E6 inhibits p53, E7 inhibits pRB protein, types 16 and 18 are responsible for most cancers Verrucae (warts), condyloma (genital warts), carcinomas Vaccination

23
Q

BK virus

A

Papovariedae dsDNA no Only cause infections in immunocompromised pts. Renal disease

24
Q

JC

A

Papovariedae dsDNA no Only cause infections in immunocompromised pts. Progressive multifocal leukoencephalopathy

25
Q

Adenoviridae

A

Adenoviridae dsDNA no Respiratory and oral-fecal transmission Acute respiratory disease, gastroenteritis supportive, live adenovirus vac.

26
Q

Parvovirus B19

A

Parvoviridae ssDNA no Aplastic anemia (infects erythroblasts) Erythema infectiosum (fifth disease), hydrops fetalis via in utero infection Supportive

27
Q

Chikungunya

A

Togavirus +ssRNA yes Arthropod vector (Aedes) Self limited, joint pain and fever Viremia, acute febrile illness, rash Supportive

28
Q

E/W equine encephalitis

A

Togavirus +ssRNA yes Arthropod vector Asymptomatic viremia that can cause encephalitis

29
Q

Venezuelan equine ence

A

Togavirus +ssRNA yes Arthropod vector Viremia with systemic manifestations

30
Q

Rubella

A

Togavirus +ssRNA yes Arthropod vector Enters via respiratory route German measles (self limiting), congenital rubella syndrome (heart, eyes, brain) Supportive

31
Q

St. Louis Encephalitis

A

Flaviviridae +ssRNA yes Arthropod vector Asymptomatic viremia that can cause encephalitis

32
Q

West Nile encephalitis

A

Flaviviridae +ssRNA yes Arthropod vector Mild flu-like to encephalitis

33
Q

Yellow fever

A

Flaviviridae +ssRNA yes Arthropod vector Viremia with systemic manifestations, liver damage

34
Q

Dengue fever

A

Flaviviridae +ssRNA yes Arthropod vector Second exposure to another serotype Dengue hemorrhagic fever

35
Q

Rhinovirus

A

Picornaviridae +ssRNA no Attach via ICAM-1 to respiratory epithelial cells common cold Supportive

36
Q

Poliovirus

A

Picornaviridae +ssRNA no Enterovirus Fecal-oral route Fever, sore throat, headaches, poliomyelitis Salk vaccine

37
Q

Coxsackie

A

Picornaviridae +ssRNA no Enterovirus Fecal-oral route Hand-foot-and-mouth-disease (group A), myocarditis and hepatis (group B) Supportive

38
Q

Echovirus

A

Picornaviridae +ssRNA no Enterovirus Fecal-oral route respiratory disease Supportive

39
Q

Rabies

A

Rhabdoviridae -ssRNA yes Bullet shaped Enters via acetylcholine receptor and retrograde to brain Encephalitis, Negri bodies, fever, salivation, hydrophobia Vaccine for pets

40
Q

Zika virus

A

Flaviviridae +ssRNA yes Arthropod vector Primates are a reservoir Fever, rash, joint and muscle pain, headache, Guillain-Barre syndrome Supportive

41
Q

Ebola

A

Filoviridae -ssRNA yes Person to person contact Fruit bats and primates are a reservoir fever, diarrhea, hemorrhage Supportive

42
Q

Powassan virus

A

Flaviviridae +ssRNA yes Deer tick transmission Encephalitis and meningitis Supportive

43
Q

SARS

A

Coronavirus +ssRNA yes Severe acute respiratory syndrome Supportive

44
Q

MERS

A

Coronavirus +ssRNA yes Similar to SARS but in middle east Supportive

45
Q

California encephalitis

A

Bunyaviridae -ssRNA yes Arthropod vector Mosquitos in Kern and Marin counties, CA Encephalitis Supportive

46
Q

La Crosse encephalitis

A

Bunyaviridae -ssRNA yes Arthropod vector mosquitos in Eastern U.S. Encephalitis Supportive

47
Q

Hantavirus

A

Bunyaviridae -ssRNA yes Aerosolized rodent excrement Hemorrhagic fever with renal failure, pulmonary syndrome Supportive

TCM Agents (6 decks)

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