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Flashcards in Viruses Deck (18)
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1

Circoviruses
Characteristics of the virus

- circular ssDNA, Ø envelop
- nucleic acid also infective, inactivation is difficult
- use cellular polymerase enzyme → young dividing cells
- high resistance, infectious for months in env
- good antigens

2

Porcine Circoviruses
Virus and diseases

PCV-1 - non pathogenic
PCV-2:
- PMWS = Post-weaning Multisystemic Wasting Syndrome
- PDNS = Porcine dermatitis nephropathy syndrome
- PRDC = Porcine respiratory disease complex
- PRF = Porcine Reproductive failure
(-PGE = Porcine granulomatous enteritis)
(-PNL = Porine Necrotising lymphadenitis)
(- PCT = Porcine Congenital tremor)
(- PEE = Porcine exudative epidermitis)

3

Avian Circoviruses
Virus and diseases

- Beak and Feather Disease (BFD)
- Pigeon Circovirus (PiCV)
- Goose Circovirus (GoCV)
- CHICKEN INFECTIOUS ANEMIA (CAV)

4

Parvo
Characteristics

- ssDNA, Ø envelop → very strong resistance
- use cellular polymerase enzyme → young dividing cells
- Good antigenicity, can induce life-long immunity
- STENOXEN

5

Parvo
Virus and diseases

- Pig: SMEDI - PPV-1
- Dog: Canine enteritis - CPV-2
- Cat: Feline Panleukopenia (feline infectious gastroenteritis) - Feline panleukopenia virus and CPV-2 (10%)
- Mink:
----- Parvoviral enteritis of Mink - mink enteritis virus
----- Aleutian Mink Disease (plasmocytosis) - aleutian mink disease virus
- Birds:
----- Goose & Muscovy ducks: Derzsy's disease (Goose plague, goose viral hepatitis, goose parvo enteritis, goose influenza) - dependoparvovirus
----- Duck parvovirus
----- Short Beak and Dwarfism syndrome - duck parvovirus

6

Papillomavirus
Characteristics

- Ø envelop → very strong resistance
- dsDNA, linear - use viral transcriptase
- Good antigens, but hidden, no cross protection
- STENOXEN, ONCOGENE
- Latent infection - genome in the nucleus
- No replication in cell culture because need keratin - epitheliotrop viruses

7

Papillomavirus
Viruses and diseases

- Bovine papillomatosis - Bovine papillomavirus (BPV)
- Horse papillomatosis - EPV2 types
- Horse Sarcoid - BPaV-1 and BPaV-2
- Dog, cat papillomatosis

8

Polyomavirus
Characteristics

- Ø envelop → very strong resistance
- dsDNA, icosahedral - - use viral transcriptase
Good antigens, but hidden, no cross protection
- STENOXEN, ONCOGENE
- Latent infection - integration in the chromosome of the cell
- in tissue culture: microtumour

9

Polyomavirus
Viruses and diseases

Most imp: Goose haemorrhagic polyomavirus = haemorrhagic nephritis and enteritis of young geese
Other:
- Budgerigar fledgling disease virus (BFDV) - parrots, falcon, finch
- Human, monkey, cattle, rodent, bat polyomavirus - oncogenic and persistent
- mouse polyomavirus - multiplex neoplasms
- hamster, rat polyomavirus
- avian polyomavirus in young parrots

10

Adenovirus
Characteristics

- dsDNA, icosahedral, Ø envelop → very strong resistance (pH 3-10, 60°C)
- Diverse pathogenicity - frequent asymptomatic carriers
- Oncogen effect
- Strong antigens - good immune response
- cross reaction within genus - serogroups

11

Adenovirus
Viruses and diseases

Dog:
- CaDV-1 → Infectious canine hepatitis - fox hepatitis - Rubarth disease
- CaDV-2 → Canine infectious laryngotracheitis - Kennel Cough
Calf and lamb: Adenoviral pneumoenteritis
- Calf: mastadenovirus genus (BAdv-1, -3, -10, -2, -9) (replication in bovine kidney cells) + atadenovirus genus (BAdv-4, -5, -8; -6; -7)
- Lamb: Mastadenovirus (BAdV-2, OAdV-2; -5; -1, -6) + Atadenovirus (OAdV-7, -1)
Poultry:
- Serogroup I: aviadenovirus
---- Chicken inclusion body hepatitis - FAdV-1, -7, -8
---- Hepatitis - hydropericardium syndrome in goose - FAdV-4
- Serogroup II: Siadenovirus - Turkey siadenovirus A
---- Turkey haemorrhagic enteritis
---- Marble spleen disease
---- Splenomegaly
- Serogroup III:
---- Egg drop syndrome - Duck Atadenovirus 1

12

Herpesvirus
Characteristics

- dsDNA, enveloped!! → weak resistance
- Immunosuppressive
- STENOXEN!! Except: Aujeszky, Malignant Catarrhal Fever, Turkey Herpes, Money herpes B
- Weak antigens = weak immune response - vaccine protection for few months only
- Cross reaction within genera, and cross protection

- α-herpes: broad spectrum, short replication cycle (<24h) + latency in neurons
- β-herpes: narrow spectrum, longer replication cycle (>24h), latency in glandular and lymphoid tissue
- γ-herpes: narrow spectrum, B and T cell tumors, immunosuppression, lymphoic cell latency and reactivation of viruses after immunosuppression

13

Herpesvirus
Viruses and diseases

α-herpes: Varicellovirus
- BHV-1 = several diseases in cattle:
---- Infectious Bovine Rhinotracheitis (IBR)
---- Infectious Pustular vulvovaginitis (IPV)
---- Balanoposthitis (IBP)
---- Conjunctivitis, abortion, encephalomyelitis, mastitis
- BHV-2 = 2 diseases → Bovine mammilitis + pseudo-lumpy skin disease
- BHV-5 = IBR
- SuHV-1 = Aujeszky's disease - pseudorabies
- EHV4 = Equine rhinopneumonitis (abortion storms)
- EHV3 = Coital Exanthema of horse
- CaHV-1
- FeHV-1 = infectious rhinotracheitis
α-herpes: Mardivirus → Marek's disease - Gallid herpes virus 2
α-herpes: Iltovirus → Gallid herpes virus 1 = Infectious Laryngotracheitis of chicken

β-herpes - unassigned - SuHV-2 = inclusion body rhinitis in pig

γ-herpes
- Macavirus = Malignant Catarrhal Fever viruses = OvHV-2 and AlHV-1, -2
- EHV-2, -5

+ Duck plague : Anatid herpes virus

14

Poxvirus
Characteristics

- dsDNA, enveloped→ resistance up to decades - very resistant - +++ parapox
- Epitheliotrop virus - replicate in cytoplasma = cytoplasmic IB
- Survival of the infection = long lasting and lifelong immunity (except parapox)
- cross reaction within genus

- Zoonotic agents: cowpox, pseudocowpox, bovine papular stomatitis, contagious pustular dermatitis of sheep and goat (orf)

- Infection - 1ry replication → Stadium erythematosum → Stadium papulosum → Stadium vesiculosum → Stadium crustosum → Stadium decrustionis

15

Poxvirus
Viruses and diseases

Orthopoxviruses "real pox virus"
- Cowpox
- Monkeypox
- Vaccinia
- Variola = small pox

Parapox "para = irregular"
- Bovine papular stomatitis virus
- Org virus = Contagious pustular dermatitis
- Pseudocowpox virus

Capripox
- sheeppox virus
- goatpoxvirus
- lumpy skin disease virus

Leporipox - Myxoma virus = myxomatosis

Avipox: fowlpox

16

Inclusions bodies:

Intranuclear inclusion bodies:
- herpesvirus
- adenovirus
- parvovirus
- poliovirus
- distemper virus

Cytoplasmic inclusion bodies:
- pox
- rabies (Negri bodies)
- distemper

17

Zoonotic diseases

Ø circo, Ø papilloma & polyoma, Ø Adeno, Ø herpes
≈ Ø parvo except
- Aleutian Mink Disease virus (parvo)

Pox: Cowpox, pseudocowpox, bovine papular stomatitis, orf virus

18

Notifiable diseases

Ø circo, Ø parvo, Ø papilloma & polyoma, Ø Adeno,

Herpes: 5
- Aujeszky's disease - Suid herpesvirus 1
- Infectious Bovine Rhinotracheitis (IBR) - BHV-1
- Equine Rhinopneumonitis - Abortion storms - EHV-4
- Infectious laryngotracheitis of chicken - Gallid herpesvirus 1
- Marek's disease - Gallid herpesvirus 2

Pox: 3
- Lumpy skin disease virus
- Sheep & Goat pox
- Myxomatosis - myxoma virus