Vitamin B12 Metabolism Flashcards
(12 cards)
What is the chemical name for Vitamin B12?
Cobalamin
What is another name for Vitamin B12, reflecting its role in a specific disease?
Antipernicious anaemia factor
What is the structure of Vitamin B12 based on?
Modified tetrapyrolle
What are the possible groups for the Xligand in Vitamin B12?
CN
Ado
Me
H2O
Name two types of Vitami B12 dependent enzymes
Methyl transferases
Adenosylcobalamin-dependent enzymes
Which organisms can synthesise Vitamin B12?
Certain eubacteria
Archaea
Do humans synthesise Vitamin B12?
No, we must obtain it from our diet
What are the two biosynthetic pathways for B12?
Oxygen-dependent (aerobic)
Oxygen-independent (anaerobic)
How do the B12 biosynthetic pathaways differ?
Timing of cobalt insertion
Ring contraction
DMB synthesis
What are the twp B12-dependent enzymes in humans and where are they located?
Methionine synthase (cytoplasm)
Methylmalonyl-CoA mutase (mitochondria)
What is the dietary source of Vitamin B12?
Fish
Meat (espicially liver)
Eggs
Diary
Fortified foods
What condition is associated with intrinsic factor issues and B12 deficiency?
Pernicious aneamia
