Vitamin B5

Question 1

What is another name for pantothenic acid?

Answer 1

Chick anti-dermatitis factor or filtrate factor

Question 2

What does the Greek word “pantos” mean?

Answer 2

Everywhere

Question 3

Why is pantothenic acid named so?

Answer 3

Because it is widely distributed in nature

Question 4

What is the metabolic role of pantothenic acid?

Answer 4

Part of coenzyme A

Question 5

What are the two components of pantothenic acid?

Answer 5

Pantoic acid and ?-alanine

Question 6

How are pantoic acid and ?-alanine linked?

Answer 6

Peptide linkage

Question 7

What is the first step in CoA synthesis?

Answer 7

Phosphorylation of pantothenate

Question 8

What is added to phosphorylated pantothenate?

Answer 8

Cysteine

Question 9

What follows cysteine addition in CoA synthesis?

Answer 9

Decarboxylation

Question 10

What is added after decarboxylation in CoA synthesis?

Answer 10

AMP moiety and phosphate

Question 11

What does ATP provide during CoA synthesis?

Answer 11

AMP moiety and phosphate

Question 12

What does the final structure of CoA contain at one end?

Answer 12

Pantothenic acid joined to beta-mercaptoethanolamine

Question 13

What connects pantothenic acid to adenylic acid in CoA?

Answer 13

Phosphate bridge

Question 14

What is adenylic acid composed of?

Answer 14

Adenine and phosphate linked to carbon-3 of ribose

Question 15

What is the functional form of pantothenic acid?

Answer 15

Coenzyme A

Question 16

What does the “A” in CoA stand for?

Answer 16

Acetylation

Question 17

Which metabolisms involve coenzyme A?

Answer 17

Carbohydrate, lipid and protein metabolism

Question 18

How many enzymes depend on coenzyme A?

Answer 18

More than 70

Question 19

What is the reactive site in CoA?

Answer 19

Terminal thiol or sulfhydryl group (-SH)

Question 20

What is CoA also known as due to its reactive group?

Answer 20

CoA-SH

Question 21

How are acyl groups linked to CoA?

Answer 21

By thioester bond

Question 22

What is formed when a fatty acid is linked to CoA?

Answer 22

Acyl CoA

Question 23

What is the name of CoA bound to acetyl group?

Answer 23

Acetyl CoA

Question 24

What is the name of CoA bound to succinate?

Answer 24

Succinyl CoA

Question 25

What is CoA�s role in metabolism?

Answer 25

Carrier of activated acetyl or acyl groups

Question 26

What is CoA�s function comparable to?

Answer 26

ATP as a carrier of phosphoryl groups

Question 27

What enzyme converts pyruvate to acetyl CoA?

Answer 27

Pyruvate dehydrogenase

Question 28

What enzyme converts ?-ketoglutarate to succinyl CoA?

Answer 28

?-Ketoglutarate dehydrogenase

Question 29

What enzyme converts fatty acid to acyl CoA?

Answer 29

Thiokinase

Question 30

What does CoA participate in regarding group transfer?

Answer 30

Transfer in CoA-bound form

Question 31

What does Acetyl CoA + Choline produce?

Answer 31

Acetylcholine + CoA

Question 32

What does Acetyl CoA + Oxaloacetate produce?

Answer 32

Citrate + CoA

Question 33

What does Succinyl CoA + Acetoacetate produce?

Answer 33

Acetoacetyl CoA + Succinate

Question 34

What is CoA regarded as in metabolism?

Answer 34

Coenzyme of metabolic integration

Question 35

Why is acetyl CoA considered central?

Answer 35

It participates in a wide variety of reactions

Question 36

What is succinyl CoA involved in besides the TCA cycle?

Answer 36

Synthesis of porphyrins of heme

Question 37

Is pantothenic acid part of fatty acid synthase?

Answer 37

Yes

Question 38

What is pantothenic acid's role in fatty acid synthase?

Answer 38

Component involved in fatty acid formation

Question 39

What is the advised daily intake of pantothenic acid?

Answer 39

5�10 mg

Question 40

Is the exact requirement for pantothenic acid known?

Answer 40

No

Question 41

What are rich sources of pantothenic acid?

Answer 41

Egg, liver, meat, yeast, milk

Question 42

Where is pantothenic acid found?

Answer 42

Plants and animals

Question 43

Are deficiency symptoms of pantothenic acid common in humans?

Answer 43

No

Question 44

Why might deficiency symptoms not be reported?

Answer 44

Widespread distribution or overlap with other deficiencies

Question 45

What syndrome did Dr. Copalan associate with deficiency?

Answer 45

Burning feet syndrome

Question 46

What are symptoms of burning feet syndrome?

Answer 46

Pain, numbness in toes, sleeplessness, fatigue

Question 47

Who linked burning feet syndrome with pantothenic acid?

Answer 47

Dr. Copalan from India

Question 48

What are deficiency symptoms seen in experimental animals?

Answer 48

Anemia, fatty liver, decreased steroid synthesis

Question 49

What is a surprising fact about pantothenic acid deficiency?

Answer 49

No clear manifestations in humans despite metabolic importance

Question 50

What forms fatty liver and anemia in pantothenic acid deficiency?

Answer 50

Lack of coenzyme A

Question 51

What condition involves decreased steroid synthesis?

Answer 51

Pantothenic acid deficiency in animals

Question 52

What makes CoA essential in metabolism?

Answer 52

Integrates multiple metabolic pathways