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Flashcards in Vitreous Deck (37)
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How much percentage wise does the vitreous take over

80% of the volume of the eye and is the largest single structure of the eye


How many mm is the vitreous chamber in a newborn? What about an adult?

Newborn: 10.5 mm
Adult: 16.5 mm


How much water is in the vitreous?

98% water


What are the non aqueous components of the vitreous

Collagen and GAGs form the vitreous into a viscoelastic gel


T/F gel content decreases with age



what types of collagen are in the vitreous?

Type II collagen: 75%
Type V and VI: 10%


What are some difficulties that arise when investigating the vitreous

1. Vitreous is supposed to be invisible
2. Previous techniques are combined with artifacts, so its hard to make interpretations on the true in vivo situation


What is the embryology of the vitreous

1. The optic cup is occupied by the lens vesicle
2. The cup grows and the space is filled by fibrillar material secreted by embryonic retina
3. The hyaloid artery penetrates and more fibrillar material from blood vessel cells fills the space
4. the mass in the end is the primary vitreous


How does the second vitreous form

1. The size of the vitreous cavity increases and the hyaloid vascular system regresses
2. Main hyaloid artery maintains for a period of time then disappears and leaves the cloquet's canal


What is Cloquet's canal

A tube of primary vitreous surrounded by secondary vitreous running from the retrolental space to the optic nerve


What refers to tertiary vitreous

Zonules of the lens, which are the suspensor fibrils that are developed from the fibrillary material


What is the mature vitreous body

A transparent gel that occupies the vitreous cavity. It has a spherical appearance, except for the anterior part, which is concave


What is the outermost part of the vitreous

Cortex; divided into an anterior and posterior cortex


What does the base consist of

Base; 3 dimensional zone extending from 2 mm anterior to 3 mm posterior to the ora serrata. This is where the collagen fibrils are densely packed


What makes up the outer part of the cortex?

The Vitreoretinal interface, which includes the retina and ILM (internal limiting membrane) and anchoring fibrils of the body


What type of collagen makes up the ILM

type IV collagen and proteglycans; considered the basal lamina of the Mueller cells


Where are the various locations that the vitreous cortex is firmly attached to

1. At the vitreous base
2. Around the optic disc (Weiss ring)
3. At the vessels
4. In the area surrounding the foveola


What do OCT findings show

That in 60% patients there are preretinal strands which are the first signs/precursors to detachment. Patient has no idea. This is asymptomatic


If foveal anatomy is not the same what happens with the patient

-Distortion occurs
-but patient sees 20/20. VA does not got down!


Ascorbic is greater in the vitreous than in the blood.



What is the vitreous' primary job

To act as a buffer


What is the same thing as Glycasaminoglycans

Hylaranic acid/ hyalourin which there is a lot in vitreous


what does the gel structure act as a barrier against

The movement of solutes by diffusion or bulk flow


When does bulk flow happen

happens as a result of possible pressure gradient from the anterior part of the eye toward the posterior pole of the eye. Only high, large molecular weight substances move due to this gradient


What is the main change in aging effects in regards to the vitreous

Main change: Liquification of the gel structure aka SYNCHYSIS, most notable in the center of the vitreous. The gel structure is dissolved and replaced with aqueous lacunae


What are other aging effects in regards to the vitreous

Vitreous collagen molecular weight increases with age because of the formation of new covalent cross links between the peptide chains.


What is the Mailard reaction

Proteins are cross linked because of this - insoluble proteins produced by a covalent bond between an amino group and glucose


What are the 4 main aspects of the vitreous

1. Support function for the retina and filling up function of the vitreous body cavity
2. Diffusion barrier between the anterior and the posterior segment of the eye.
3. Metabolic buffer function
4. Establishment of an unhindered path of light


How does the vitreous support the retina?

Helps prevent a large retinal detachment and absorbs external forces to protect globe deformation


What is a posterior vitreous detachment

The central degeneration is large and causes a collapse --> the cortex sinks to the center of the vitreous body. Considered a normal aging phenomena